Details for: Notch1
Associated with
Other Information
Genular Protein ID: 3912811137
Symbol: NOTC1_MOUSE
Name: Neurogenic locus notch homolog protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8449489
Title: Cloning, analysis, and chromosomal localization of Notch-1, a mouse homolog of Drosophila Notch.
PubMed ID: 8449489
PubMed ID: 7956822
Title: An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells.
PubMed ID: 7956822
PubMed ID: 12123574
Title: Glycogen synthase kinase-3beta modulates notch signaling and stability.
PubMed ID: 12123574
PubMed ID: 12807718
Title: Radiation-induced deletions in the 5' end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas.
PubMed ID: 12807718
PubMed ID: 19468303
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
PubMed ID: 19468303
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1426644
Title: Expression analysis of a Notch homologue in the mouse embryo.
PubMed ID: 1426644
PubMed ID: 8440332
Title: Motch A and Motch B-two mouse Notch homologues coexpressed in a wide variety of tissues.
PubMed ID: 8440332
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 1425352
Title: Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development.
PubMed ID: 1425352
PubMed ID: 9653148
Title: The Notch1 receptor is cleaved constitutively by a furin-like convertase.
PubMed ID: 9653148
PubMed ID: 10437788
Title: Murine leukemia provirus-mediated activation of the Notch1 gene leads to induction of HES-1 in a mouse T lymphoma cell line, DL-3.
PubMed ID: 10437788
PubMed ID: 8486742
Title: Mouse notch: expression in hair follicles correlates with cell fate determination.
PubMed ID: 8486742
PubMed ID: 18299578
Title: Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.
PubMed ID: 18299578
PubMed ID: 9384671
Title: Dynamic changes in gene expression during in vitro differentiation of mouse embryonic stem cells.
PubMed ID: 9384671
PubMed ID: 10882062
Title: A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1.
PubMed ID: 10882062
PubMed ID: 10882063
Title: A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE.
PubMed ID: 10882063
PubMed ID: 11518718
Title: Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.
PubMed ID: 11518718
PubMed ID: 11459941
Title: Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.
PubMed ID: 11459941
PubMed ID: 11226752
Title: Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis.
PubMed ID: 11226752
PubMed ID: 12050162
Title: The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway.
PubMed ID: 12050162
PubMed ID: 15019995
Title: Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene.
PubMed ID: 15019995
PubMed ID: 15240571
Title: Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor.
PubMed ID: 15240571
PubMed ID: 15965470
Title: DNER acts as a neuron-specific Notch ligand during Bergmann glial development.
PubMed ID: 15965470
DOI: 10.1038/nn1492
PubMed ID: 18430783
Title: Zfp64 participates in Notch signaling and regulates differentiation in mesenchymal cells.
PubMed ID: 18430783
DOI: 10.1242/jcs.023119
PubMed ID: 18628966
Title: AIP4/Itch regulates Notch receptor degradation in the absence of ligand.
PubMed ID: 18628966
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 21464124
Title: The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway.
PubMed ID: 21464124
PubMed ID: 21757702
Title: O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1.
PubMed ID: 21757702
PubMed ID: 23160044
Title: BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets.
PubMed ID: 23160044
DOI: 10.1038/nn.3264
PubMed ID: 23886940
Title: Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals.
PubMed ID: 23886940
DOI: 10.1242/jcs.130500
PubMed ID: 23615612
Title: Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4.
PubMed ID: 23615612
DOI: 10.1038/nature12069
PubMed ID: 25038227
Title: NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis.
PubMed ID: 25038227
PubMed ID: 28089369
Title: Deciphering the fringe-mediated notch code: identification of activating and inhibiting sites allowing discrimination between ligands.
PubMed ID: 28089369
PubMed ID: 28498977
Title: Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions.
PubMed ID: 28498977
DOI: 10.1093/hmg/ddx189
PubMed ID: 30127001
Title: Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling.
PubMed ID: 30127001
PubMed ID: 15802643
Title: The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold.
PubMed ID: 15802643
DOI: 10.1110/ps.041184105
PubMed ID: 17573339
Title: Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.
PubMed ID: 17573339
Sequence Information:
- Length: 2531
- Mass: 270835
- Checksum: 97C91F69BABF02BF
- Sequence:
MPRLLTPLLC LTLLPALAAR GLRCSQPSGT CLNGGRCEVA NGTEACVCSG AFVGQRCQDS NPCLSTPCKN AGTCHVVDHG GTVDYACSCP LGFSGPLCLT PLDNACLANP CRNGGTCDLL TLTEYKCRCP PGWSGKSCQQ ADPCASNPCA NGGQCLPFES SYICRCPPGF HGPTCRQDVN ECSQNPGLCR HGGTCHNEIG SYRCACRATH TGPHCELPYV PCSPSPCQNG GTCRPTGDTT HECACLPGFA GQNCEENVDD CPGNNCKNGG ACVDGVNTYN CRCPPEWTGQ YCTEDVDECQ LMPNACQNGG TCHNTHGGYN CVCVNGWTGE DCSENIDDCA SAACFQGATC HDRVASFYCE CPHGRTGLLC HLNDACISNP CNEGSNCDTN PVNGKAICTC PSGYTGPACS QDVDECALGA NPCEHAGKCL NTLGSFECQC LQGYTGPRCE IDVNECISNP CQNDATCLDQ IGEFQCICMP GYEGVYCEIN TDECASSPCL HNGHCMDKIN EFQCQCPKGF NGHLCQYDVD ECASTPCKNG AKCLDGPNTY TCVCTEGYTG THCEVDIDEC DPDPCHYGSC KDGVATFTCL CQPGYTGHHC ETNINECHSQ PCRHGGTCQD RDNSYLCLCL KGTTGPNCEI NLDDCASNPC DSGTCLDKID GYECACEPGY TGSMCNVNID ECAGSPCHNG GTCEDGIAGF TCRCPEGYHD PTCLSEVNEC NSNPCIHGAC RDGLNGYKCD CAPGWSGTNC DINNNECESN PCVNGGTCKD MTSGYVCTCR EGFSGPNCQT NINECASNPC LNQGTCIDDV AGYKCNCPLP YTGATCEVVL APCATSPCKN SGVCKESEDY ESFSCVCPTG WQGQTCEVDI NECVKSPCRH GASCQNTNGS YRCLCQAGYT GRNCESDIDD CRPNPCHNGG SCTDGINTAF CDCLPGFQGA FCEEDINECA SNPCQNGANC TDCVDSYTCT CPVGFNGIHC ENNTPDCTES SCFNGGTCVD GINSFTCLCP PGFTGSYCQY DVNECDSRPC LHGGTCQDSY GTYKCTCPQG YTGLNCQNLV RWCDSAPCKN GGRCWQTNTQ YHCECRSGWT GVNCDVLSVS CEVAAQKRGI DVTLLCQHGG LCVDEGDKHY CHCQAGYTGS YCEDEVDECS PNPCQNGATC TDYLGGFSCK CVAGYHGSNC SEEINECLSQ PCQNGGTCID LTNSYKCSCP RGTQGVHCEI NVDDCHPPLD PASRSPKCFN NGTCVDQVGG YTCTCPPGFV GERCEGDVNE CLSNPCDPRG TQNCVQRVND FHCECRAGHT GRRCESVING CRGKPCKNGG VCAVASNTAR GFICRCPAGF EGATCENDAR TCGSLRCLNG GTCISGPRSP TCLCLGSFTG PECQFPASSP CVGSNPCYNQ GTCEPTSENP FYRCLCPAKF NGLLCHILDY SFTGGAGRDI PPPQIEEACE LPECQVDAGN KVCNLQCNNH ACGWDGGDCS LNFNDPWKNC TQSLQCWKYF SDGHCDSQCN SAGCLFDGFD CQLTEGQCNP LYDQYCKDHF SDGHCDQGCN SAECEWDGLD CAEHVPERLA AGTLVLVVLL PPDQLRNNSF HFLRELSHVL HTNVVFKRDA QGQQMIFPYY GHEEELRKHP IKRSTVGWAT SSLLPGTSGG RQRRELDPMD IRGSIVYLEI DNRQCVQSSS QCFQSATDVA AFLGALASLG SLNIPYKIEA VKSEPVEPPL PSQLHLMYVA AAAFVLLFFV GCGVLLSRKR RRQHGQLWFP EGFKVSEASK KKRREPLGED SVGLKPLKNA SDGALMDDNQ NEWGDEDLET KKFRFEEPVV LPDLSDQTDH RQWTQQHLDA ADLRMSAMAP TPPQGEVDAD CMDVNVRGPD GFTPLMIASC SGGGLETGNS EEEEDAPAVI SDFIYQGASL HNQTDRTGET ALHLAARYSR SDAAKRLLEA SADANIQDNM GRTPLHAAVS ADAQGVFQIL LRNRATDLDA RMHDGTTPLI LAARLAVEGM LEDLINSHAD VNAVDDLGKS ALHWAAAVNN VDAAVVLLKN GANKDMQNNK EETPLFLAAR EGSYETAKVL LDHFANRDIT DHMDRLPRDI AQERMHHDIV RLLDEYNLVR SPQLHGTALG GTPTLSPTLC SPNGYLGNLK SATQGKKARK PSTKGLACGS KEAKDLKARR KKSQDGKGCL LDSSSMLSPV DSLESPHGYL SDVASPPLLP SPFQQSPSMP LSHLPGMPDT HLGISHLNVA AKPEMAALAG GSRLAFEPPP PRLSHLPVAS SASTVLSTNG TGAMNFTVGA PASLNGQCEW LPRLQNGMVP SQYNPLRPGV TPGTLSTQAA GLQHSMMGPL HSSLSTNTLS PIIYQGLPNT RLATQPHLVQ TQQVQPQNLQ LQPQNLQPPS QPHLSVSSAA NGHLGRSFLS GEPSQADVQP LGPSSLPVHT ILPQESQALP TSLPSSMVPP MTTTQFLTPP SQHSYSSSPV DNTPSHQLQV PEHPFLTPSP ESPDQWSSSS PHSNISDWSE GISSPPTTMP SQITHIPEAF K
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.