Genular: Defining Cellular Identity and Function

Details for: Notch1

Gene ID: 18128

Symbol: Notch1

Ensembl ID: ENSMUSG00000026923

Description: notch 1

Associated with

Activated notch1 transmits signal to the nucleus
(R-MMU-2122948)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Notch-hlh transcription pathway
(R-MMU-350054)
Notch1 intracellular domain regulates transcription
(R-MMU-2122947)
Pre-notch expression and processing
(R-MMU-1912422)
Pre-notch processing in golgi
(R-MMU-1912420)
Rna polymerase ii transcription
(R-MMU-73857)
Runx3 regulates notch signaling
(R-MMU-8941856)
Signaling by notch
(R-MMU-157118)
Signaling by notch1
(R-MMU-1980143)
Signal transduction
(R-MMU-162582)
Transcriptional regulation by runx3
(R-MMU-8878159)
Angiogenesis
(GO:0001525)
Aortic valve morphogenesis
(GO:0003180)
Apoptotic process
(GO:0006915)
Atrioventricular node development
(GO:0003162)
Atrioventricular valve morphogenesis
(GO:0003181)
Axon guidance
(GO:0007411)
Axonogenesis
(GO:0007409)
Calcium ion binding
(GO:0005509)
Cardiac atrium morphogenesis
(GO:0003209)
Cardiac chamber formation
(GO:0003207)
Cardiac left ventricle morphogenesis
(GO:0003214)
Cardiac right atrium morphogenesis
(GO:0003213)
Cardiac right ventricle formation
(GO:0003219)
Cardiac ventricle morphogenesis
(GO:0003208)
Cell migration involved in endocardial cushion formation
(GO:0003273)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Compartment pattern specification
(GO:0007386)
Coronary sinus valve morphogenesis
(GO:0003182)
Coronary vein morphogenesis
(GO:0003169)
Determination of left/right symmetry
(GO:0007368)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Endocardial cushion development
(GO:0003197)
Endocardial cushion morphogenesis
(GO:0003203)
Endocardium development
(GO:0003157)
Endocardium morphogenesis
(GO:0003160)
Enzyme binding
(GO:0019899)
Enzyme inhibitor activity
(GO:0004857)
Epithelial to mesenchymal transition
(GO:0001837)
Epithelial to mesenchymal transition involved in endocardial cushion formation
(GO:0003198)
Growth involved in heart morphogenesis
(GO:0003241)
Heart looping
(GO:0001947)
Humoral immune response
(GO:0006959)
Identical protein binding
(GO:0042802)
Inflammatory response to antigenic stimulus
(GO:0002437)
Inhibition of neuroepithelial cell differentiation
(GO:0002085)
In utero embryonic development
(GO:0001701)
Liver development
(GO:0001889)
Metal ion binding
(GO:0046872)
Mitral valve formation
(GO:0003192)
Multicellular organism development
(GO:0007275)
Negative regulation of cell proliferation involved in heart valve morphogenesis
(GO:0003252)
Negative regulation of extracellular matrix constituent secretion
(GO:0003332)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Notch binding
(GO:0005112)
Notch signaling pathway
(GO:0007219)
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
(GO:0003270)
Osteoblast fate commitment
(GO:0002051)
Outflow tract morphogenesis
(GO:0003151)
Pericardium morphogenesis
(GO:0003344)
Positive regulation of neuroblast proliferation
(GO:0002052)
Positive regulation of transcription of notch receptor target
(GO:0007221)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Pulmonary valve morphogenesis
(GO:0003184)
Regulation of cardioblast proliferation
(GO:0003264)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Signaling receptor activity
(GO:0038023)
Spermatogenesis
(GO:0007283)
Sprouting angiogenesis
(GO:0002040)
Transcription by rna polymerase ii
(GO:0006366)
Transcription coactivator activity
(GO:0003713)
Transcription regulator activator activity
(GO:0140537)
Transmembrane signaling receptor activity
(GO:0004888)
Ventricular trabecula myocardium morphogenesis
(GO:0003222)

Other Information

Proteins

Neurogenic locus notch homolog protein 1

Genular Protein ID: 3912811137

Symbol: NOTC1_MOUSE

Name: Neurogenic locus notch homolog protein 1

UniProtKB Accession Codes:

Q01705 Q06007 Q3TZW2 Q3U3Y2 Q61905 Q7TQ50 Q7TQ51 Q7TQ52 Q8K428 Q99JC2 Q9QW58 Q9R0X7

Database IDs:

Citations:

PubMed ID: 8449489

Title: Cloning, analysis, and chromosomal localization of Notch-1, a mouse homolog of Drosophila Notch.

PubMed ID: 8449489

DOI: 10.1006/geno.1993.1055

PubMed ID: 7956822

Title: An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells.

PubMed ID: 7956822

DOI: 10.1242/dev.120.9.2421

PubMed ID: 12123574

Title: Glycogen synthase kinase-3beta modulates notch signaling and stability.

PubMed ID: 12123574

DOI: 10.1016/s0960-9822(02)00888-6

PubMed ID: 12807718

Title: Radiation-induced deletions in the 5' end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas.

PubMed ID: 12807718

DOI: 10.1093/carcin/bgg071

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1426644

Title: Expression analysis of a Notch homologue in the mouse embryo.

PubMed ID: 1426644

DOI: 10.1016/0012-1606(92)90076-s

PubMed ID: 8440332

Title: Motch A and Motch B-two mouse Notch homologues coexpressed in a wide variety of tissues.

PubMed ID: 8440332

DOI: 10.1006/excr.1993.1044

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 1425352

Title: Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development.

PubMed ID: 1425352

DOI: 10.1242/dev.115.3.737

PubMed ID: 9653148

Title: The Notch1 receptor is cleaved constitutively by a furin-like convertase.

PubMed ID: 9653148

DOI: 10.1073/pnas.95.14.8108

PubMed ID: 10437788

Title: Murine leukemia provirus-mediated activation of the Notch1 gene leads to induction of HES-1 in a mouse T lymphoma cell line, DL-3.

PubMed ID: 10437788

DOI: 10.1016/s0014-5793(99)00901-1

PubMed ID: 8486742

Title: Mouse notch: expression in hair follicles correlates with cell fate determination.

PubMed ID: 8486742

DOI: 10.1083/jcb.121.3.631

PubMed ID: 18299578

Title: Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.

PubMed ID: 18299578

DOI: 10.1073/pnas.0711591105

PubMed ID: 9384671

Title: Dynamic changes in gene expression during in vitro differentiation of mouse embryonic stem cells.

PubMed ID: 9384671

PubMed ID: 10882062

Title: A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1.

PubMed ID: 10882062

DOI: 10.1016/s1097-2765(00)80416-5

PubMed ID: 10882063

Title: A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE.

PubMed ID: 10882063

DOI: 10.1016/s1097-2765(00)80417-7

PubMed ID: 11518718

Title: Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.

PubMed ID: 11518718

DOI: 10.1074/jbc.m107234200

PubMed ID: 11459941

Title: Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.

PubMed ID: 11459941

DOI: 10.1073/pnas.161269998

PubMed ID: 11226752

Title: Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis.

PubMed ID: 11226752

DOI: 10.1016/s0736-5748(00)00071-x

PubMed ID: 12050162

Title: The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway.

PubMed ID: 12050162

DOI: 10.1074/jbc.m203727200

PubMed ID: 15019995

Title: Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene.

PubMed ID: 15019995

DOI: 10.1016/j.gene.2003.12.007

PubMed ID: 15240571

Title: Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor.

PubMed ID: 15240571

DOI: 10.1083/jcb.200310098

PubMed ID: 15965470

Title: DNER acts as a neuron-specific Notch ligand during Bergmann glial development.

PubMed ID: 15965470

DOI: 10.1038/nn1492

PubMed ID: 18430783

Title: Zfp64 participates in Notch signaling and regulates differentiation in mesenchymal cells.

PubMed ID: 18430783

DOI: 10.1242/jcs.023119

PubMed ID: 18628966

Title: AIP4/Itch regulates Notch receptor degradation in the absence of ligand.

PubMed ID: 18628966

DOI: 10.1371/journal.pone.0002735

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21464124

Title: The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway.

PubMed ID: 21464124

DOI: 10.1074/jbc.m110.190769

PubMed ID: 21757702

Title: O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1.

PubMed ID: 21757702

DOI: 10.1074/jbc.m111.268243

PubMed ID: 23160044

Title: BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets.

PubMed ID: 23160044

DOI: 10.1038/nn.3264

PubMed ID: 23886940

Title: Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals.

PubMed ID: 23886940

DOI: 10.1242/jcs.130500

PubMed ID: 23615612

Title: Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4.

PubMed ID: 23615612

DOI: 10.1038/nature12069

PubMed ID: 25038227

Title: NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis.

PubMed ID: 25038227

DOI: 10.1158/0008-5472.can-14-1547

PubMed ID: 28089369

Title: Deciphering the fringe-mediated notch code: identification of activating and inhibiting sites allowing discrimination between ligands.

PubMed ID: 28089369

DOI: 10.1016/j.devcel.2016.12.013

PubMed ID: 28498977

Title: Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions.

PubMed ID: 28498977

DOI: 10.1093/hmg/ddx189

PubMed ID: 30127001

Title: Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling.

PubMed ID: 30127001

DOI: 10.1073/pnas.1804005115

PubMed ID: 15802643

Title: The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold.

PubMed ID: 15802643

DOI: 10.1110/ps.041184105

PubMed ID: 17573339

Title: Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.

PubMed ID: 17573339

DOI: 10.1074/jbc.m704102200

Sequence Information:

Length: 2531
Mass: 270835
Checksum: 97C91F69BABF02BF
Sequence:

MPRLLTPLLC LTLLPALAAR GLRCSQPSGT CLNGGRCEVA NGTEACVCSG AFVGQRCQDS 
NPCLSTPCKN AGTCHVVDHG GTVDYACSCP LGFSGPLCLT PLDNACLANP CRNGGTCDLL 
TLTEYKCRCP PGWSGKSCQQ ADPCASNPCA NGGQCLPFES SYICRCPPGF HGPTCRQDVN 
ECSQNPGLCR HGGTCHNEIG SYRCACRATH TGPHCELPYV PCSPSPCQNG GTCRPTGDTT 
HECACLPGFA GQNCEENVDD CPGNNCKNGG ACVDGVNTYN CRCPPEWTGQ YCTEDVDECQ 
LMPNACQNGG TCHNTHGGYN CVCVNGWTGE DCSENIDDCA SAACFQGATC HDRVASFYCE 
CPHGRTGLLC HLNDACISNP CNEGSNCDTN PVNGKAICTC PSGYTGPACS QDVDECALGA 
NPCEHAGKCL NTLGSFECQC LQGYTGPRCE IDVNECISNP CQNDATCLDQ IGEFQCICMP 
GYEGVYCEIN TDECASSPCL HNGHCMDKIN EFQCQCPKGF NGHLCQYDVD ECASTPCKNG 
AKCLDGPNTY TCVCTEGYTG THCEVDIDEC DPDPCHYGSC KDGVATFTCL CQPGYTGHHC 
ETNINECHSQ PCRHGGTCQD RDNSYLCLCL KGTTGPNCEI NLDDCASNPC DSGTCLDKID 
GYECACEPGY TGSMCNVNID ECAGSPCHNG GTCEDGIAGF TCRCPEGYHD PTCLSEVNEC 
NSNPCIHGAC RDGLNGYKCD CAPGWSGTNC DINNNECESN PCVNGGTCKD MTSGYVCTCR 
EGFSGPNCQT NINECASNPC LNQGTCIDDV AGYKCNCPLP YTGATCEVVL APCATSPCKN 
SGVCKESEDY ESFSCVCPTG WQGQTCEVDI NECVKSPCRH GASCQNTNGS YRCLCQAGYT 
GRNCESDIDD CRPNPCHNGG SCTDGINTAF CDCLPGFQGA FCEEDINECA SNPCQNGANC 
TDCVDSYTCT CPVGFNGIHC ENNTPDCTES SCFNGGTCVD GINSFTCLCP PGFTGSYCQY 
DVNECDSRPC LHGGTCQDSY GTYKCTCPQG YTGLNCQNLV RWCDSAPCKN GGRCWQTNTQ 
YHCECRSGWT GVNCDVLSVS CEVAAQKRGI DVTLLCQHGG LCVDEGDKHY CHCQAGYTGS 
YCEDEVDECS PNPCQNGATC TDYLGGFSCK CVAGYHGSNC SEEINECLSQ PCQNGGTCID 
LTNSYKCSCP RGTQGVHCEI NVDDCHPPLD PASRSPKCFN NGTCVDQVGG YTCTCPPGFV 
GERCEGDVNE CLSNPCDPRG TQNCVQRVND FHCECRAGHT GRRCESVING CRGKPCKNGG 
VCAVASNTAR GFICRCPAGF EGATCENDAR TCGSLRCLNG GTCISGPRSP TCLCLGSFTG 
PECQFPASSP CVGSNPCYNQ GTCEPTSENP FYRCLCPAKF NGLLCHILDY SFTGGAGRDI 
PPPQIEEACE LPECQVDAGN KVCNLQCNNH ACGWDGGDCS LNFNDPWKNC TQSLQCWKYF 
SDGHCDSQCN SAGCLFDGFD CQLTEGQCNP LYDQYCKDHF SDGHCDQGCN SAECEWDGLD 
CAEHVPERLA AGTLVLVVLL PPDQLRNNSF HFLRELSHVL HTNVVFKRDA QGQQMIFPYY 
GHEEELRKHP IKRSTVGWAT SSLLPGTSGG RQRRELDPMD IRGSIVYLEI DNRQCVQSSS 
QCFQSATDVA AFLGALASLG SLNIPYKIEA VKSEPVEPPL PSQLHLMYVA AAAFVLLFFV 
GCGVLLSRKR RRQHGQLWFP EGFKVSEASK KKRREPLGED SVGLKPLKNA SDGALMDDNQ 
NEWGDEDLET KKFRFEEPVV LPDLSDQTDH RQWTQQHLDA ADLRMSAMAP TPPQGEVDAD 
CMDVNVRGPD GFTPLMIASC SGGGLETGNS EEEEDAPAVI SDFIYQGASL HNQTDRTGET 
ALHLAARYSR SDAAKRLLEA SADANIQDNM GRTPLHAAVS ADAQGVFQIL LRNRATDLDA 
RMHDGTTPLI LAARLAVEGM LEDLINSHAD VNAVDDLGKS ALHWAAAVNN VDAAVVLLKN 
GANKDMQNNK EETPLFLAAR EGSYETAKVL LDHFANRDIT DHMDRLPRDI AQERMHHDIV 
RLLDEYNLVR SPQLHGTALG GTPTLSPTLC SPNGYLGNLK SATQGKKARK PSTKGLACGS 
KEAKDLKARR KKSQDGKGCL LDSSSMLSPV DSLESPHGYL SDVASPPLLP SPFQQSPSMP 
LSHLPGMPDT HLGISHLNVA AKPEMAALAG GSRLAFEPPP PRLSHLPVAS SASTVLSTNG 
TGAMNFTVGA PASLNGQCEW LPRLQNGMVP SQYNPLRPGV TPGTLSTQAA GLQHSMMGPL 
HSSLSTNTLS PIIYQGLPNT RLATQPHLVQ TQQVQPQNLQ LQPQNLQPPS QPHLSVSSAA 
NGHLGRSFLS GEPSQADVQP LGPSSLPVHT ILPQESQALP TSLPSSMVPP MTTTQFLTPP 
SQHSYSSSPV DNTPSHQLQV PEHPFLTPSP ESPDQWSSSS PHSNISDWSE GISSPPTTMP 
SQITHIPEAF K

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Notch1

Associated with

Other Information

Cloning, analysis, and chromosomal localization of Notch-1, a mouse homolog of Drosophila Notch. PubMed ID: 8449489

An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. PubMed ID: 7956822

Glycogen synthase kinase-3beta modulates notch signaling and stability. PubMed ID: 12123574

Radiation-induced deletions in the 5' end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas. PubMed ID: 12807718

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression analysis of a Notch homologue in the mouse embryo. PubMed ID: 1426644

Motch A and Motch B-two mouse Notch homologues coexpressed in a wide variety of tissues. PubMed ID: 8440332

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. PubMed ID: 1425352

The Notch1 receptor is cleaved constitutively by a furin-like convertase. PubMed ID: 9653148

Murine leukemia provirus-mediated activation of the Notch1 gene leads to induction of HES-1 in a mouse T lymphoma cell line, DL-3. PubMed ID: 10437788

Mouse notch: expression in hair follicles correlates with cell fate determination. PubMed ID: 8486742

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. PubMed ID: 18299578

Dynamic changes in gene expression during in vitro differentiation of mouse embryonic stem cells. PubMed ID: 9384671

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. PubMed ID: 10882062

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. PubMed ID: 10882063

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis. PubMed ID: 11518718

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members. PubMed ID: 11459941

Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. PubMed ID: 11226752

The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway. PubMed ID: 12050162

Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene. PubMed ID: 15019995

Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor. PubMed ID: 15240571

DNER acts as a neuron-specific Notch ligand during Bergmann glial development. PubMed ID: 15965470

Zfp64 participates in Notch signaling and regulates differentiation in mesenchymal cells. PubMed ID: 18430783

AIP4/Itch regulates Notch receptor degradation in the absence of ligand. PubMed ID: 18628966

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway. PubMed ID: 21464124

O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1. PubMed ID: 21757702

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets. PubMed ID: 23160044

Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals. PubMed ID: 23886940

Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. PubMed ID: 23615612

NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis. PubMed ID: 25038227

Deciphering the fringe-mediated notch code: identification of activating and inhibiting sites allowing discrimination between ligands. PubMed ID: 28089369

Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions. PubMed ID: 28498977

Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling. PubMed ID: 30127001

The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold. PubMed ID: 15802643

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. PubMed ID: 17573339