Genular: Defining Cellular Identity and Function

Details for: Notch2

Gene ID: 18129

Symbol: Notch2

Ensembl ID: ENSMUSG00000027878

Description: notch 2

Associated with

Activation of protein kinase b activity
(GO:0032148)
Animal organ morphogenesis
(GO:0009887)
Apoptotic process
(GO:0006915)
Atrial septum morphogenesis
(GO:0060413)
Bmp signaling pathway
(GO:0030509)
Bone remodeling
(GO:0046849)
Calcium ion binding
(GO:0005509)
Cell differentiation
(GO:0030154)
Cell fate determination
(GO:0001709)
Cell population proliferation
(GO:0008283)
Cell surface
(GO:0009986)
Cellular response to tumor cell
(GO:0071228)
Cholangiocyte proliferation
(GO:1990705)
Ciliary body morphogenesis
(GO:0061073)
Cilium
(GO:0005929)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to bacterium
(GO:0042742)
Determination of left/right symmetry
(GO:0007368)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Embryonic limb morphogenesis
(GO:0030326)
Enzyme binding
(GO:0019899)
Extracellular region
(GO:0005576)
Glial cell differentiation
(GO:0010001)
Glomerular capillary formation
(GO:0072104)
Heart looping
(GO:0001947)
Hepatocyte proliferation
(GO:0072574)
Humoral immune response
(GO:0006959)
Inflammatory response to antigenic stimulus
(GO:0002437)
Interleukin-4 production
(GO:0032633)
Intracellular signal transduction
(GO:0035556)
Intrahepatic bile duct development
(GO:0035622)
In utero embryonic development
(GO:0001701)
Left/right axis specification
(GO:0070986)
Liver development
(GO:0001889)
Liver morphogenesis
(GO:0072576)
Marginal zone b cell differentiation
(GO:0002315)
Membrane
(GO:0016020)
Morphogenesis of an epithelial sheet
(GO:0002011)
Multicellular organism development
(GO:0007275)
Multicellular organism growth
(GO:0035264)
Myeloid dendritic cell differentiation
(GO:0043011)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nf-kappab binding
(GO:0051059)
Notch signaling pathway
(GO:0007219)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Placenta blood vessel development
(GO:0060674)
Placenta development
(GO:0001890)
Plasma membrane
(GO:0005886)
Podocyte development
(GO:0072015)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of keratinocyte proliferation
(GO:0010838)
Positive regulation of mirna transcription
(GO:1902895)
Positive regulation of neuroblast proliferation
(GO:0002052)
Positive regulation of osteoclast differentiation
(GO:0045672)
Positive regulation of ras protein signal transduction
(GO:0046579)
Positive regulation of smooth muscle cell differentiation
(GO:0051152)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Proximal tubule development
(GO:0072014)
Pulmonary valve morphogenesis
(GO:0003184)
Receptor complex
(GO:0043235)
Regulation of developmental process
(GO:0050793)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of osteoclast development
(GO:2001204)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Signaling receptor activity
(GO:0038023)
Transmembrane signaling receptor activity
(GO:0004888)
Wound healing
(GO:0042060)

Other Information

Proteins

Notch 2 extracellular truncation

Genular Protein ID: 2919699043

Symbol: NOTC2_MOUSE

Name: Notch 2 extracellular truncation

UniProtKB Accession Codes:

O35516 G5E8J0 Q06008 Q60941

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 8440332

Title: Motch A and Motch B-two mouse Notch homologues coexpressed in a wide variety of tissues.

PubMed ID: 8440332

DOI: 10.1006/excr.1993.1044

PubMed ID: 8917536

Title: Inhibition of granulocytic differentiation by mNotch1.

PubMed ID: 8917536

DOI: 10.1073/pnas.93.23.13014

PubMed ID: 10393120

Title: Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality.

PubMed ID: 10393120

DOI: 10.1242/dev.126.15.3415

PubMed ID: 7609614

Title: Differential expression of Notch1 and Notch2 in developing and adult mouse brain.

PubMed ID: 7609614

DOI: 10.1016/0169-328x(94)00257-f

PubMed ID: 11518718

Title: Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.

PubMed ID: 11518718

DOI: 10.1074/jbc.m107234200

PubMed ID: 11459941

Title: Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.

PubMed ID: 11459941

DOI: 10.1073/pnas.161269998

PubMed ID: 15019995

Title: Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene.

PubMed ID: 15019995

DOI: 10.1016/j.gene.2003.12.007

PubMed ID: 17573339

Title: Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.

PubMed ID: 17573339

DOI: 10.1074/jbc.m704102200

PubMed ID: 18710934

Title: The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis.

PubMed ID: 18710934

DOI: 10.1128/mcb.00299-08

PubMed ID: 18299578

Title: Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.

PubMed ID: 18299578

DOI: 10.1073/pnas.0711591105

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21949356

Title: Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase.

PubMed ID: 21949356

DOI: 10.1073/pnas.1109696108

Sequence Information:

Length: 2473
Mass: 265633
Checksum: 3A9067BBE3B1F480
Sequence:

MPALRPAALR ALLWLWLCGA GPAHALQCRG GQEPCVNEGT CVTYHNGTGF CRCPEGFLGE 
YCQHRDPCEK NRCQNGGTCV PQGMLGKATC RCAPGFTGED CQYSTSHPCF VSRPCQNGGT 
CHMLSRDTYE CTCQVGFTGK QCQWTDACLS HPCENGSTCT SVASQFSCKC PAGLTGQKCE 
ADINECDIPG RCQHGGTCLN LPGSYRCQCP QGFTGQHCDS PYVPCAPSPC VNGGTCRQTG 
DFTFECNCLP GFEGSTCERN IDDCPNHKCQ NGGVCVDGVN TYNCRCPPQW TGQFCTEDVD 
ECLLQPNACQ NGGTCTNRNG GYGCVCVNGW SGDDCSENID DCAYASCTPG STCIDRVASF 
SCLCPEGKAG LLCHLDDACI SNPCHKGALC DTNPLNGQYI CTCPQGYKGA DCTEDVDECA 
MANSNPCEHA GKCVNTDGAF HCECLKGYAG PRCEMDINEC HSDPCQNDAT CLDKIGGFTC 
LCMPGFKGVH CELEVNECQS NPCVNNGQCV DKVNRFQCLC PPGFTGPVCQ IDIDDCSSTP 
CLNGAKCIDH PNGYECQCAT GFTGILCDEN IDNCDPDPCH HGQCQDGIDS YTCICNPGYM 
GAICSDQIDE CYSSPCLNDG RCIDLVNGYQ CNCQPGTSGL NCEINFDDCA SNPCMHGVCV 
DGINRYSCVC SPGFTGQRCN IDIDECASNP CRKGATCIND VNGFRCICPE GPHHPSCYSQ 
VNECLSNPCI HGNCTGGLSG YKCLCDAGWV GVNCEVDKNE CLSNPCQNGG TCNNLVNGYR 
CTCKKGFKGY NCQVNIDECA SNPCLNQGTC FDDVSGYTCH CMLPYTGKNC QTVLAPCSPN 
PCENAAVCKE APNFESFSCL CAPGWQGKRC TVDVDECISK PCMNNGVCHN TQGSYVCECP 
PGFSGMDCEE DINDCLANPC QNGGSCVDHV NTFSCQCHPG FIGDKCQTDM NECLSEPCKN 
GGTCSDYVNS YTCTCPAGFH GVHCENNIDE CTESSCFNGG TCVDGINSFS CLCPVGFTGP 
FCLHDINECS SNPCLNAGTC VDGLGTYRCI CPLGYTGKNC QTLVNLCSRS PCKNKGTCVQ 
EKARPHCLCP PGWDGAYCDV LNVSCKAAAL QKGVPVEHLC QHSGICINAG NTHHCQCPLG 
YTGSYCEEQL DECASNPCQH GATCNDFIGG YRCECVPGYQ GVNCEYEVDE CQNQPCQNGG 
TCIDLVNHFK CSCPPGTRGL LCEENIDECA GGPHCLNGGQ CVDRIGGYTC RCLPGFAGER 
CEGDINECLS NPCSSEGSLD CVQLKNNYNC ICRSAFTGRH CETFLDVCPQ KPCLNGGTCA 
VASNMPDGFI CRCPPGFSGA RCQSSCGQVK CRRGEQCIHT DSGPRCFCLN PKDCESGCAS 
NPCQHGGTCY PQRQPPHYSC RCPPSFGGSH CELYTAPTST PPATCQSQYC ADKARDGICD 
EACNSHACQW DGGDCSLTME DPWANCTSTL RCWEYINNQC DEQCNTAECL FDNFECQRNS 
KTCKYDKYCA DHFKDNHCDQ GCNSEECGWD GLDCASDQPE NLAEGTLIIV VLLPPEQLLQ 
DSRSFLRALG TLLHTNLRIK QDSQGALMVY PYFGEKSAAM KKQKMTRRSL PEEQEQEQEV 
IGSKIFLEID NRQCVQDSDQ CFKNTDAAAA LLASHAIQGT LSYPLVSVFS ELESPRNAQL 
LYLLAVAVVI ILFFILLGVI MAKRKRKHGF LWLPEGFTLR RDSSNHKRRE PVGQDAVGLK 
NLSVQVSEAN LIGSGTSEHW VDDEGPQPKK AKAEDEALLS EDDPIDRRPW TQQHLEAADI 
RHTPSLALTP PQAEQEVDVL DVNVRGPDGC TPLMLASLRG GSSDLSDEDE DAEDSSANII 
TDLVYQGASL QAQTDRTGEM ALHLAARYSR ADAAKRLLDA GADANAQDNM GRCPLHAAVA 
ADAQGVFQIL IRNRVTDLDA RMNDGTTPLI LAARLAVEGM VAELINCQAD VNAVDDHGKS 
ALHWAAAVNN VEATLLLLKN GANRDMQDNK EETPLFLAAR EGSYEAAKIL LDHFANRDIT 
DHMDRLPRDV ARDRMHHDIV RLLDEYNVTP SPPGTVLTSA LSPVLCGPNR SFLSLKHTPM 
GKKARRPNTK STMPTSLPNL AKEAKDAKGS RRKKCLNEKV QLSESSVTLS PVDSLESPHT 
YVSDATSSPM ITSPGILQAS PTPLLAAAAP AAPVHTQHAL SFSNLHDMQP LAPGASTVLP 
SVSQLLSHHH IAPPGSSSAG SLGRLHPVPV PADWMNRVEM NETQYSEMFG MVLAPAEGAH 
PGIAAPQSRP PEGKHMSTQR EPLPPIVTFQ LIPKGSIAQA AGAPQTQSSC PPAVAGPLPS 
MYQIPEMPRL PSVAFPPTMM PQQEGQVAQT IVPTYHPFPA SVGKYPTPPS QHSYASSNAA 
ERTPSHGGHL QGEHPYLTPS PESPDQWSSS SPHSASDWSD VTTSPTPGGG GGGQRGPGTH 
MSEPPHSNMQ VYA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Notch2

Associated with

Other Information

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Motch A and Motch B-two mouse Notch homologues coexpressed in a wide variety of tissues. PubMed ID: 8440332

Inhibition of granulocytic differentiation by mNotch1. PubMed ID: 8917536

Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality. PubMed ID: 10393120

Differential expression of Notch1 and Notch2 in developing and adult mouse brain. PubMed ID: 7609614

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis. PubMed ID: 11518718

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members. PubMed ID: 11459941

Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene. PubMed ID: 15019995

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. PubMed ID: 17573339

The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis. PubMed ID: 18710934

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. PubMed ID: 18299578

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase. PubMed ID: 21949356