Genular: Defining Cellular Identity and Function

Details for: Notch4

Gene ID: 18132

Symbol: Notch4

Ensembl ID: ENSMUSG00000015468

Description: notch 4

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Negative regulation of notch4 signaling
(R-MMU-9604323)
Notch-hlh transcription pathway
(R-MMU-350054)
Notch4 activation and transmission of signal to the nucleus
(R-MMU-9013700)
Pre-notch expression and processing
(R-MMU-1912422)
Pre-notch processing in golgi
(R-MMU-1912420)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by notch
(R-MMU-157118)
Signaling by notch4
(R-MMU-9013694)
Signal transduction
(R-MMU-162582)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Calcium ion binding
(GO:0005509)
Cell differentiation
(GO:0030154)
Cell surface
(GO:0009986)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Endoplasmic reticulum
(GO:0005783)
Endothelial cell differentiation
(GO:0045446)
Endothelial cell morphogenesis
(GO:0001886)
Epithelial to mesenchymal transition
(GO:0001837)
Mammary gland development
(GO:0030879)
Membrane
(GO:0016020)
Morphogenesis of a branching structure
(GO:0001763)
Multicellular organism development
(GO:0007275)
Negative regulation of cell-cell adhesion mediated by cadherin
(GO:2000048)
Negative regulation of cell adhesion molecule production
(GO:0060354)
Negative regulation of endothelial cell differentiation
(GO:0045602)
Negative regulation of notch signaling pathway
(GO:0045746)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Notch binding
(GO:0005112)
Notch signaling pathway
(GO:0007219)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of aorta morphogenesis
(GO:1903849)
Positive regulation of smooth muscle cell differentiation
(GO:0051152)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of developmental process
(GO:0050793)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of notch signaling pathway
(GO:0008593)
Regulation of protein localization
(GO:0032880)
Regulation of protein processing
(GO:0070613)
Signaling receptor activity
(GO:0038023)
Vasculature development
(GO:0001944)
Venous blood vessel morphogenesis
(GO:0048845)

Other Information

Proteins

Transforming protein Int-3

Genular Protein ID: 836162103

Symbol: NOTC4_MOUSE

Name: Transforming protein Int-3

UniProtKB Accession Codes:

P31695 A2CG28 O35442 O88314 O88316 Q62389 Q62390 Q9R1W9 Q9R1X0

Database IDs:

Citations:

PubMed ID: 1312643

Title: Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells.

PubMed ID: 1312643

DOI: 10.1128/jvi.66.4.2594-2599.1992

PubMed ID: 9150355

Title: The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4).

PubMed ID: 9150355

DOI: 10.1038/sj.onc.1201035

PubMed ID: 8681805

Title: Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene.

PubMed ID: 8681805

DOI: 10.1242/dev.122.7.2251

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 11518718

Title: Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.

PubMed ID: 11518718

DOI: 10.1074/jbc.m107234200

PubMed ID: 10233982

Title: Intracisternal type A particle-mediated activation of the Notch4/int3 gene in a mouse mammary tumor: generation of truncated Notch4/int3 mRNAs by retroviral splicing events.

PubMed ID: 10233982

DOI: 10.1128/jvi.73.6.5166-5171.1999

PubMed ID: 11344305

Title: Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium.

PubMed ID: 11344305

DOI: 10.1073/pnas.091584598

PubMed ID: 11459941

Title: Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.

PubMed ID: 11459941

DOI: 10.1073/pnas.161269998

PubMed ID: 15019995

Title: Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene.

PubMed ID: 15019995

DOI: 10.1016/j.gene.2003.12.007

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 1964
Mass: 206702
Checksum: 53D7F86394FC40BD
Sequence:

MQPQLLLLLL LPLNFPVILT RELLCGGSPE PCANGGTCLR LSRGQGICQC APGFLGETCQ 
FPDPCRDTQL CKNGGSCQAL LPTPPSSRSP TSPLTPHFSC TCPSGFTGDR CQTHLEELCP 
PSFCSNGGHC YVQASGRPQC SCEPGWTGEQ CQLRDFCSAN PCANGGVCLA TYPQIQCRCP 
PGFEGHTCER DINECFLEPG PCPQGTSCHN TLGSYQCLCP VGQEGPQCKL RKGACPPGSC 
LNGGTCQLVP EGHSTFHLCL CPPGFTGLDC EMNPDDCVRH QCQNGATCLD GLDTYTCLCP 
KTWKGWDCSE DIDECEARGP PRCRNGGTCQ NTAGSFHCVC VSGWGGAGCE ENLDDCAAAT 
CAPGSTCIDR VGSFSCLCPP GRTGLLCHLE DMCLSQPCHV NAQCSTNPLT GSTLCICQPG 
YSGSTCHQDL DECQMAQQGP SPCEHGGSCI NTPGSFNCLC LPGYTGSRCE ADHNECLSQP 
CHPGSTCLDL LATFHCLCPP GLEGRLCEVE VNECTSNPCL NQAACHDLLN GFQCLCLPGF 
TGARCEKDMD ECSSTPCANG GRCRDQPGAF YCECLPGFEG PHCEKEVDEC LSDPCPVGAS 
CLDLPGAFFC LCRPGFTGQL CEVPLCTPNM CQPGQQCQGQ EHRAPCLCPD GSPGCVPAED 
NCPCHHGHCQ RSLCVCDEGW TGPECETELG GCISTPCAHG GTCHPQPSGY NCTCPAGYMG 
LTCSEEVTAC HSGPCLNGGS CSIRPEGYSC TCLPSHTGRH CQTAVDHCVS ASCLNGGTCV 
NKPGTFFCLC ATGFQGLHCE EKTNPSCADS PCRNKATCQD TPRGARCLCS PGYTGSSCQT 
LIDLCARKPC PHTARCLQSG PSFQCLCLQG WTGALCDFPL SCQKAAMSQG IEISGLCQNG 
GLCIDTGSSY FCRCPPGFQG KLCQDNVNPC EPNPCHHGST CVPQPSGYVC QCAPGYEGQN 
CSKVLDACQS QPCHNHGTCT SRPGGFHCAC PPGFVGLRCE GDVDECLDRP CHPSGTAACH 
SLANAFYCQC LPGHTGQRCE VEMDLCQSQP CSNGGSCEIT TGPPPGFTCH CPKGFEGPTC 
SHKALSCGIH HCHNGGLCLP SPKPGSPPLC ACLSGFGGPD CLTPPAPPGC GPPSPCLHNG 
TCTETPGLGN PGFQCTCPPD SPGPRCQRPG ASGCEGRGGD GTCDAGCSGP GGDWDGGDCS 
LGVPDPWKGC PPHSQCWLLF RDGRCHPQCD SEECLFDGYD CEIPLTCIPA YDQYCRDHFH 
NGHCEKGCNN AECGWDGGDC RPEGEDSEGR PSLALLVVLR PPALDQQLLA LARVLSLTLR 
VGLWVRKDSE GRNMVFPYPG TRAKEELSGA RDSSSWERQA PPTQPLGKET ESLGAGFVVV 
MGVDLSRCGP EHPASRCPWD SGLLLRFLAA MAAVGALEPL LPGPLLAAHP QAGTRPSANQ 
LPWPILCSPV VGVLLLALGA LLVLQLIRRR RREHGALWLP PGFIRRPQTQ QAPHRRRPPL 
GEDNIGLKAL KPEAEVDEDG VAMCSGPEEG EAEETASASR CQLWPLNSGC GELPQAAMLT 
PPQECESEVL DVDTCGPDGV TPLMSAVFCG GVQSTTGASP QRLGLGNLEP WEPLLDRGAC 
PQAHTVGTGE TPLHLAARFS RPTAARRLLE AGANPNQPDR AGRTPLHTAV AADAREVCQL 
LLASRQTTVD ARTEDGTTPL MLAARLAVED LVEELIAARA DVGARDKRGK TALHWAAAVN 
NARAARSLLQ AGADKDAQDS REQTPLFLAA REGAVEVAQL LLELGAARGL RDQAGLAPGD 
VARQRSHWDL LTLLEGAGPT TQEARAHART TPGGGAAPRC RTLSAGARPR GGGACLQART 
WSVDLGARGG KVYARCRSRS GSCGGPTTRG RRFSAGSRGR RGARASQDDW PRDWVALEAC 
GSACSAPIPP PSLTPSPERG SPQVAWGLPV HQEIPLNSVV RNLN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Notch4

Associated with

Other Information

Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells. PubMed ID: 1312643

The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4). PubMed ID: 9150355

Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. PubMed ID: 8681805

Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. PubMed ID: 14656967

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis. PubMed ID: 11518718

Intracisternal type A particle-mediated activation of the Notch4/int3 gene in a mouse mammary tumor: generation of truncated Notch4/int3 mRNAs by retroviral splicing events. PubMed ID: 10233982

Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium. PubMed ID: 11344305

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members. PubMed ID: 11459941

Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene. PubMed ID: 15019995

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079