Genular: Defining Cellular Identity and Function

Details for: Ccn3

Gene ID: 18133

Symbol: Ccn3

Ensembl ID: ENSMUSG00000037362

Description: cellular communication network factor 3

Associated with

Anchoring junction
(GO:0070161)
Angiogenesis
(GO:0001525)
Axon
(GO:0030424)
Bone regeneration
(GO:1990523)
Cell adhesion
(GO:0007155)
Cell adhesion mediated by integrin
(GO:0033627)
Cell chemotaxis
(GO:0060326)
Chondrocyte differentiation
(GO:0002062)
Collagen-containing extracellular matrix
(GO:0062023)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Endothelial cell-cell adhesion
(GO:0071603)
Endothelial cell chemotaxis
(GO:0035767)
Extracellular matrix
(GO:0031012)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast migration
(GO:0010761)
Gap junction
(GO:0005921)
Growth factor activity
(GO:0008083)
Hematopoietic stem cell homeostasis
(GO:0061484)
Heparin binding
(GO:0008201)
Integrin binding
(GO:0005178)
Intracellular membrane-bounded organelle
(GO:0043231)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of chondrocyte proliferation
(GO:1902731)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of insulin secretion
(GO:0046676)
Negative regulation of monocyte chemotaxis
(GO:0090027)
Negative regulation of myotube differentiation
(GO:0010832)
Negative regulation of non-canonical nf-kappab signal transduction
(GO:1901223)
Negative regulation of sensory perception of pain
(GO:1904057)
Negative regulation of smad protein signal transduction
(GO:0060392)
Neuronal cell body
(GO:0043025)
Notch binding
(GO:0005112)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of notch signaling pathway
(GO:0045747)
Regulation of gene expression
(GO:0010468)
Signal transduction
(GO:0007165)
Smooth muscle cell migration
(GO:0014909)
Smooth muscle cell proliferation
(GO:0048659)
Type b pancreatic cell proliferation
(GO:0044342)

Other Information

Proteins

Nephroblastoma-overexpressed gene protein homolog

Genular Protein ID: 2589712696

Symbol: CCN3_MOUSE

Name: Nephroblastoma-overexpressed gene protein homolog

UniProtKB Accession Codes:

Q64299 Q8CA67

Database IDs:

Citations:

PubMed ID: 8975721

Title: Genomic structure and chromosomal mapping of the mouse nov gene.

PubMed ID: 8975721

DOI: 10.1006/geno.1996.0647

PubMed ID: 8622864

Title: Regulation of nov by WT1: a potential role for nov in nephrogenesis.

PubMed ID: 8622864

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12050162

Title: The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway.

PubMed ID: 12050162

DOI: 10.1074/jbc.m203727200

PubMed ID: 15213231

Title: CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression.

PubMed ID: 15213231

DOI: 10.1074/jbc.m403952200

PubMed ID: 15611078

Title: Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing.

PubMed ID: 15611078

DOI: 10.1074/jbc.m404903200

PubMed ID: 20139355

Title: CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration.

PubMed ID: 20139355

DOI: 10.1161/atvbaha.110.203356

PubMed ID: 21063504

Title: A novel role of CCN3 in regulating endothelial inflammation.

PubMed ID: 21063504

DOI: 10.1007/s12079-010-0095-x

PubMed ID: 23653360

Title: CCN3 protein participates in bone regeneration as an inhibitory factor.

PubMed ID: 23653360

DOI: 10.1074/jbc.m113.454652

PubMed ID: 23705021

Title: Nov/Ccn3, a novel transcriptional target of FoxO1, impairs pancreatic beta-cell function.

PubMed ID: 23705021

DOI: 10.1371/journal.pone.0064957

PubMed ID: 24722330

Title: Overexpression of CCN3 inhibits inflammation and progression of atherosclerosis in apolipoprotein E-deficient mice.

PubMed ID: 24722330

DOI: 10.1371/journal.pone.0094912

PubMed ID: 29287726

Title: CCN3 secretion is regulated by palmitoylation via ZDHHC22.

PubMed ID: 29287726

DOI: 10.1016/j.bbrc.2017.12.128

Sequence Information:

Length: 354
Mass: 38928
Checksum: 08ECE8CFC67829DE
Sequence:

MSLFLRKRCL CLGFLLFHLL SQVSASLRCP SRCPPKCPSI SPTCAPGVRS VLDGCSCCPV 
CARQRGESCS EMRPCDQSSG LYCDRSADPN NQTGICMVPE GDNCVFDGVI YRNGEKFEPN 
CQYFCTCRDG QIGCLPRCQL DVLLPGPDCP APRKVAVPGE CCEKWTCGSD EQGTQGTLGG 
LALPAYRPEA TVGVEVSDSS INCIEQTTEW SACSKSCGMG VSTRVTNRNR QCEMVKQTRL 
CIVRPCEQEP EEVTDKKGKK CLRTKKSLKA IHLQFENCTS LYTYKPRFCG VCSDGRCCTP 
HNTKTIQVEF QCLPGEIIKK PVMVIGTCTC YSNCPQNNEA FLQDLELKTS RGEI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ccn3

Associated with

Other Information

Genomic structure and chromosomal mapping of the mouse nov gene. PubMed ID: 8975721

Regulation of nov by WT1: a potential role for nov in nephrogenesis. PubMed ID: 8622864

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway. PubMed ID: 12050162

CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression. PubMed ID: 15213231

Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing. PubMed ID: 15611078

CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration. PubMed ID: 20139355

A novel role of CCN3 in regulating endothelial inflammation. PubMed ID: 21063504

CCN3 protein participates in bone regeneration as an inhibitory factor. PubMed ID: 23653360

Nov/Ccn3, a novel transcriptional target of FoxO1, impairs pancreatic beta-cell function. PubMed ID: 23705021

Overexpression of CCN3 inhibits inflammation and progression of atherosclerosis in apolipoprotein E-deficient mice. PubMed ID: 24722330

CCN3 secretion is regulated by palmitoylation via ZDHHC22. PubMed ID: 29287726