Details for: Uhrf1
Associated with
Other Information
Genular Protein ID: 4064694427
Symbol: UHRF1_MOUSE
Name: E3 ubiquitin-protein ligase UHRF1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9880673
Title: Cloning and mapping of Np95 gene which encodes a novel nuclear protein associated with cell proliferation.
PubMed ID: 9880673
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 19468303
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
PubMed ID: 19468303
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12084726
Title: Targeted disruption of Np95 gene renders murine embryonic stem cells hypersensitive to DNA damaging agents and DNA replication blocks.
PubMed ID: 12084726
PubMed ID: 8634372
Title: The characterization of the monoclonal antibody Th-10a, specific for a nuclear protein appearing in the S phase of the cell cycle in normal thymocytes and its unregulated expression in lymphoma cell lines.
PubMed ID: 8634372
PubMed ID: 10984098
Title: Temporal and spatial localization of novel nuclear protein NP95 in mitotic and meiotic cells.
PubMed ID: 10984098
DOI: 10.1247/csf.25.149
PubMed ID: 11161719
Title: Dynamic changes in subnuclear NP95 location during the cell cycle and its spatial relationship with DNA replication foci.
PubMed ID: 11161719
PubMed ID: 12058012
Title: Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry.
PubMed ID: 12058012
PubMed ID: 14993289
Title: Np95 is a histone-binding protein endowed with ubiquitin ligase activity.
PubMed ID: 14993289
PubMed ID: 15361834
Title: ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain.
PubMed ID: 15361834
PubMed ID: 17994007
Title: The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA.
PubMed ID: 17994007
DOI: 10.1038/nature06397
PubMed ID: 17673620
Title: UHRF1 plays a role in maintaining DNA methylation in mammalian cells.
PubMed ID: 17673620
PubMed ID: 19798101
Title: Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells.
PubMed ID: 19798101
PubMed ID: 19144319
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
PubMed ID: 19144319
PubMed ID: 19056828
Title: UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells.
PubMed ID: 19056828
DOI: 10.1093/nar/gkn961
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 20026581
Title: The multi-domain protein Np95 connects DNA methylation and histone modification.
PubMed ID: 20026581
DOI: 10.1093/nar/gkp1152
PubMed ID: 21489993
Title: Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.
PubMed ID: 21489993
PubMed ID: 21268065
Title: Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1.
PubMed ID: 21268065
DOI: 10.1002/jcb.22998
PubMed ID: 28604677
Title: Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.
PubMed ID: 28604677
DOI: 10.1038/ncb3554
PubMed ID: 36056023
Title: Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation.
PubMed ID: 36056023
PubMed ID: 18772891
Title: Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism.
PubMed ID: 18772891
DOI: 10.1038/nature07249
PubMed ID: 18772888
Title: The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix.
PubMed ID: 18772888
DOI: 10.1038/nature07280
PubMed ID: 19077538
Title: UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications.
PubMed ID: 19077538
DOI: 10.4161/epi.4.1.7370
Sequence Information:
- Length: 782
- Mass: 88304
- Checksum: DC5EEDFCDF69619B
- Sequence:
MWIQVRTMDG KETHTVNSLS RLTKVQELRK KIEEVFHVEP QLQRLFYRGK QMEDGHTLFD YDVRLNDTIQ LLVRQSLALP LSTKERDSEL SDSDSGYGVG HSESDKSSTH GEGAAEADDK TVWEDTDLGL YKVNEYVDVR DNIFGAWFEA QVVQVQKRAL SEDEPCSSSA VKTSEDDIMY HVKYDDYPEH GVDIVKAKNV RARARTVIPW ENLEVGQVVM ANYNVDYPRK RGFWYDVEIC RKRQTRTARE LYGNIRLLND SQLNNCRIMF VDEVLMIELP KERRPLIASP SQPPPALRNT GKSGPSCRFC KDDENKPCRK CACHVCGGRE APEKQLLCDE CDMAFHLYCL KPPLTSVPPE PEWYCPSCRT DSSEVVQAGE KLKESKKKAK MASATSSSRR DWGKGMACVG RTTECTIVPA NHFGPIPGVP VGTMWRFRVQ VSESGVHRPH VAGIHGRSND GAYSLVLAGG YEDDVDNGNY FTYTGSGGRD LSGNKRTAGQ SSDQKLTNNN RALALNCHSP INEKGAEAED WRQGKPVRVV RNMKGGKHSK YAPAEGNRYD GIYKVVKYWP ERGKSGFLVW RYLLRRDDTE PEPWTREGKD RTRQLGLTMQ YPEGYLEALA NKEKSRKRPA KALEQGPSSS KTGKSKQKST GPTLSSPRAS KKSKLEPYTL SEQQANLIKE DKGNAKLWDD VLTSLQDGPY QIFLSKVKEA FQCICCQELV FRPVTTVCQH NVCKDCLDRS FRAQVFSCPA CRFELDHSSP TRVNQPLQTI LNQLFPGYGS GR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.