Details for: Npas1

Gene ID: 18142

Symbol: Npas1

Ensembl ID: ENSMUSG00000001988

Description: neuronal PAS domain protein 1

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Maternal behavior
    (GO:0042711)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Protein heterodimerization activity
    (GO:0046982)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Startle response
    (GO:0001964)

Other Information

Genular Protein ID: 1994256195

Symbol: NPAS1_MOUSE

Name: Neuronal PAS domain-containing protein 1

UniProtKB Accession Codes:

P97459

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 2 CTD 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 6 KEGG 1 MGI 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PaxDb 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 9012850

Title: Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system.

PubMed ID: 9012850

DOI: 10.1073/pnas.94.2.713

PubMed ID: 15347806

Title: Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors.

PubMed ID: 15347806

DOI: 10.1073/pnas.0405310101

PubMed ID: 15635607

Title: Novel function of neuronal PAS domain protein 1 in erythropoietin expression in neuronal cells.

PubMed ID: 15635607

DOI: 10.1002/jnr.20365

PubMed ID: 27782878

Title: NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.

PubMed ID: 27782878

DOI: 10.7554/elife.18790

Sequence Information:

  • Length: 594
  • Mass: 63737
  • Checksum: D6477696DF69A4B3
  • Sequence:
    • MATPYPRSGG RGEVKCGGGR GAGVPWDFLP GLMVKAPPGP CLQAQRKEKS RNAARWRRGK 
ENLEFFELAK LLPLPGAISS QLDKASIVRL SVTYLRLRRF AALGAPPWGL RAVGPPAGLA 
PGRRGPVALV SEVFEQHLGG HILQSLDGFV FALNQEGKFL YISETVSIYL GLSQVELTGS 
SVFDYIHPGD HSEVLEQLGL RAASIGPPTP PSVSSSSSSS SSSLVDTPEI EASPTEASPA 
FRAQERSFFV RMKSTLTKRG LNVKASGYKV IHVTGRLRAR ALGLVALGHT LPPAPLAELP 
LHGHMIVFRL SLGLTILACE SRVSDHMDMG PSELVGRSCY QFVHGQDATR IRQSHLDLLD 
KGQVVTGYYR WLQRAGGFVW LQSVATVAGN GKSTGEHHVL WVSHVLSNAE GSQTPLDAFQ 
LPAIVSQEEP SRPGPEPTEE EPPVDGKQAV PADQDKDKDP QARGKRIKVE ASPKEARGSE 
DSGEEELSDP PAPPRPEFTS VIRAGALKHD PVLPWGLTTP GDPSPALLHA GFLPPVVRGL 
CTPGTIRYGP AELSLMYPHL HRLGAGPSLP EAFYPTLGLP YPGPTGTRVQ RKGD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.