Genular: Defining Cellular Identity and Function

Details for: Nr1i2

Gene ID: 18171

Symbol: Nr1i2

Ensembl ID: ENSMUSG00000022809

Description: nuclear receptor subfamily 1, group I, member 2

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Nuclear receptor transcription pathway
(R-MMU-383280)
Post-translational protein modification
(R-MMU-597592)
Rna polymerase ii transcription
(R-MMU-73857)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of intracellular receptors
(R-MMU-4090294)
Cell differentiation
(GO:0030154)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna binding
(GO:0003677)
Intermediate filament cytoskeleton
(GO:0045111)
Metal ion binding
(GO:0046872)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear body
(GO:0016604)
Nuclear receptor activity
(GO:0004879)
Nuclear receptor binding
(GO:0016922)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription regulator complex
(GO:0005667)
Xenobiotic catabolic process
(GO:0042178)
Xenobiotic metabolic process
(GO:0006805)
Xenobiotic transport
(GO:0042908)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Nuclear receptor subfamily 1 group I member 2

Genular Protein ID: 3535124846

Symbol: NR1I2_MOUSE

Name: Nuclear receptor subfamily 1 group I member 2

UniProtKB Accession Codes:

O54915

Database IDs:

Citations:

PubMed ID: 9489701

Title: An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.

PubMed ID: 9489701

DOI: 10.1016/s0092-8674(00)80900-9

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 12606758

Title: Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR.

PubMed ID: 12606758

DOI: 10.1124/mol.63.3.524

PubMed ID: 12569201

Title: Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance.

PubMed ID: 12569201

DOI: 10.1073/pnas.0336235100

PubMed ID: 19297428

Title: Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner.

PubMed ID: 19297428

DOI: 10.3945/jn.108.103572

PubMed ID: 28751364

Title: Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.

PubMed ID: 28751364

DOI: 10.1073/pnas.1704955114

Sequence Information:

Length: 431
Mass: 49567
Checksum: F592AF91F689329E
Sequence:

MRPEESWSRV GLVQCEEADS ALEEPINVEE EDGGLQICRV CGDKANGYHF NVMTCEGCKG 
FFRRAMKRNV RLRCPFRKGT CEITRKTRRQ CQACRLRKCL ESGMKKEMIM SDAAVEQRRA 
LIKRKKREKI EAPPPGGQGL TEEQQALIQE LMDAQMQTFD TTFSHFKDFR LPAVFHSGCE 
LPEFLQASLL EDPATWSQIM KDRVPMKISL QLRGEDGSIW NYQPPSKSDG KEIIPLLPHL 
ADVSTYMFKG VINFAKVISY FRDLPIEDQI SLLKGATFEM CILRFNTMFD TETGTWECGR 
LAYCFEDPNG GFQKLLLDPL MKFHCMLKKL QLHKEEYVLM QAISLFSPDR PGVVQRSVVD 
QLQERFALTL KAYIECSRPY PAHRFLFLKI MAVLTELRSI NAQQTQQLLR IQDSHPFATP 
LMQELFSSTD G

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nr1i2

Associated with

Other Information

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. PubMed ID: 9489701

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR. PubMed ID: 12606758

Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. PubMed ID: 12569201

Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner. PubMed ID: 19297428