Genular: Defining Cellular Identity and Function

Details for: Slc11a1

Gene ID: 18173

Symbol: Slc11a1

Ensembl ID: ENSMUSG00000026177

Description: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1

Associated with

Antimicrobial peptides
(R-MMU-6803157)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Ion influx/efflux at host-pathogen interface
(R-MMU-6803544)
Metal ion slc transporters
(R-MMU-425410)
Neutrophil degranulation
(R-MMU-6798695)
Ros and rns production in phagocytes
(R-MMU-1222556)
Slc-mediated transmembrane transport
(R-MMU-425407)
Transport of bile salts and organic acids, metal ions and amine compounds
(R-MMU-425366)
Transport of small molecules
(R-MMU-382551)
Activation of protein kinase activity
(GO:0032147)
Antigen processing and presentation of peptide antigen
(GO:0048002)
Cadmium ion transmembrane transport
(GO:0070574)
Cadmium ion transmembrane transporter activity
(GO:0015086)
Cellular detoxification of cadmium ion
(GO:0098849)
Defense response to bacterium
(GO:0042742)
Defense response to gram-negative bacterium
(GO:0050829)
Defense response to protozoan
(GO:0042832)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Establishment of localization in cell
(GO:0051649)
Inflammatory response
(GO:0006954)
Interleukin-2 production
(GO:0032623)
Interleukin-3 production
(GO:0032632)
Intracellular iron ion homeostasis
(GO:0006879)
Iron ion transmembrane transport
(GO:0034755)
Iron ion transmembrane transporter activity
(GO:0005381)
Iron ion transport
(GO:0006826)
L-arginine transmembrane transport
(GO:1903826)
Late endosome
(GO:0005770)
Late endosome membrane
(GO:0031902)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Macrophage activation
(GO:0042116)
Manganese ion transmembrane transporter activity
(GO:0005384)
Manganese ion transport
(GO:0006828)
Membrane
(GO:0016020)
Metal cation:proton antiporter activity
(GO:0051139)
Metal ion transmembrane transporter activity
(GO:0046873)
Metal ion transport
(GO:0030001)
Mhc class ii biosynthetic process
(GO:0045342)
Monoatomic ion transport
(GO:0006811)
Mrna stabilization
(GO:0048255)
Multicellular organismal-level iron ion homeostasis
(GO:0060586)
Negative regulation of cytokine production
(GO:0001818)
Nitrite transport
(GO:0015707)
Phagocytic vesicle membrane
(GO:0030670)
Phagocytosis
(GO:0006909)
Plasma membrane
(GO:0005886)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of dendritic cell antigen processing and presentation
(GO:0002606)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of t-helper 1 type immune response
(GO:0002827)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of type ii interferon production
(GO:0032729)
Protein homodimerization activity
(GO:0042803)
Respiratory burst
(GO:0045730)
Response to bacterium
(GO:0009617)
Response to lipopolysaccharide
(GO:0032496)
Response to type ii interferon
(GO:0034341)
T cell cytokine production
(GO:0002369)
T cell proliferation involved in immune response
(GO:0002309)
Tertiary granule membrane
(GO:0070821)
Transition metal ion transmembrane transporter activity
(GO:0046915)
Type ii interferon production
(GO:0032609)
Vacuolar acidification
(GO:0007035)
Wound healing
(GO:0042060)

Other Information

Proteins

Natural resistance-associated macrophage protein 1

Genular Protein ID: 950313656

Symbol: NRAM1_MOUSE

Name: Natural resistance-associated macrophage protein 1

UniProtKB Accession Codes:

P41251 Q3TB84

Database IDs:

Citations:

PubMed ID: 7513015

Title: NH2-terminal sequence of macrophage-expressed natural resistance-associated macrophage protein (Nramp) encodes a proline/serine-rich putative Src homology 3-binding domain.

PubMed ID: 7513015

DOI: 10.1084/jem.179.5.1683

PubMed ID: 7665187

Title: Genomic structure, promoter sequence, and induction of expression of the mouse Nramp1 gene in macrophages.

PubMed ID: 7665187

DOI: 10.1006/geno.1995.1002

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8490962

Title: Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg.

PubMed ID: 8490962

DOI: 10.1016/0092-8674(93)90135-d

PubMed ID: 8757814

Title: The Bcg/Ity/Lsh locus: genetic transfer of resistance to infections in C57BL/6J mice transgenic for the Nramp1 Gly169 allele.

PubMed ID: 8757814

DOI: 10.1128/iai.64.8.2923-2929.1996

PubMed ID: 8871656

Title: Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains.

PubMed ID: 8871656

PubMed ID: 9730978

Title: Localisation of Nramp1 in macrophages: modulation with activation and infection.

PubMed ID: 9730978

DOI: 10.1242/jcs.111.19.2855

PubMed ID: 11237855

Title: Natural-resistance-associated macrophage protein 1 is an H+/bivalent cation antiporter.

PubMed ID: 11237855

DOI: 10.1042/0264-6021:3540511

PubMed ID: 15202932

Title: Incomplete glycosylation and defective intracellular targeting of mutant solute carrier family 11 member 1 (Slc11a1).

PubMed ID: 15202932

DOI: 10.1042/bj20040808

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 548
Mass: 59741
Checksum: E5F0C1EC9FC0C2FD
Sequence:

MISDKSPPRL SRPSYGSISS LPGPAPQPAP CRETYLSEKI PIPSADQGTF SLRKLWAFTG 
PGFLMSIAFL DPGNIESDLQ AGAVAGFKLL WVLLWATVLG LLCQRLAARL GVVTGKDLGE 
VCHLYYPKVP RILLWLTIEL AIVGSDMQEV IGTAISFNLL SAGRIPLWDG VLITIVDTFF 
FLFLDNYGLR KLEAFFGLLI TIMALTFGYE YVVAHPSQGA LLKGLVLPTC PGCGQPELLQ 
AVGIVGAIIM PHNIYLHSAL VKSREVDRTR RVDVREANMY FLIEATIALS VSFIINLFVM 
AVFGQAFYQQ TNEEAFNICA NSSLQNYAKI FPRDNNTVSV DIYQGGVILG CLFGPAALYI 
WAVGLLAAGQ SSTMTGTYAG QFVMEGFLKL RWSRFARVLL TRSCAILPTV LVAVFRDLKD 
LSGLNDLLNV LQSLLLPFAV LPILTFTSMP AVMQEFANGR MSKAITSCIM ALVCAINLYF 
VISYLPSLPH PAYFGLVALF AIGYLGLTAY LAWTCCIAHG ATFLTHSSHK HFLYGLPNEE 
QGGVQGSG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc11a1

Associated with

Other Information

NH2-terminal sequence of macrophage-expressed natural resistance-associated macrophage protein (Nramp) encodes a proline/serine-rich putative Src homology 3-binding domain. PubMed ID: 7513015

Genomic structure, promoter sequence, and induction of expression of the mouse Nramp1 gene in macrophages. PubMed ID: 7665187

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. PubMed ID: 8490962

The Bcg/Ity/Lsh locus: genetic transfer of resistance to infections in C57BL/6J mice transgenic for the Nramp1 Gly169 allele. PubMed ID: 8757814

Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains. PubMed ID: 8871656

Localisation of Nramp1 in macrophages: modulation with activation and infection. PubMed ID: 9730978

Natural-resistance-associated macrophage protein 1 is an H+/bivalent cation antiporter. PubMed ID: 11237855

Incomplete glycosylation and defective intracellular targeting of mutant solute carrier family 11 member 1 (Slc11a1). PubMed ID: 15202932

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079