Genular: Defining Cellular Identity and Function

Details for: Nrp1

Gene ID: 18186

Symbol: Nrp1

Ensembl ID: ENSMUSG00000025810

Description: neuropilin 1

Associated with

Crmps in sema3a signaling
(R-MMU-399956)
Developmental biology
(R-MMU-1266738)
L1cam interactions
(R-MMU-373760)
Neurophilin interactions with vegf and vegfr
(R-MMU-194306)
Sema3a-plexin repulsion signaling by inhibiting integrin adhesion
(R-MMU-399955)
Sema3a pak dependent axon repulsion
(R-MMU-399954)
Semaphorin interactions
(R-MMU-373755)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Signal transduction by l1
(R-MMU-445144)
Angiogenesis
(GO:0001525)
Artery morphogenesis
(GO:0048844)
Axonal fasciculation
(GO:0007413)
Axon extension
(GO:0048675)
Axon extension involved in axon guidance
(GO:0048846)
Axon guidance
(GO:0007411)
Blood vessel endothelial cell migration
(GO:0043534)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Branchiomotor neuron axon guidance
(GO:0021785)
Cardiac neural crest cell migration involved in outflow tract morphogenesis
(GO:0003253)
Cell differentiation
(GO:0030154)
Cell migration involved in sprouting angiogenesis
(GO:0002042)
Cellular response to hepatocyte growth factor stimulus
(GO:0035729)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Dendrite development
(GO:0016358)
Endothelial cell chemotaxis
(GO:0035767)
Endothelial cell migration
(GO:0043542)
Facial nerve structural organization
(GO:0021612)
Gonadotrophin-releasing hormone neuronal migration to the hypothalamus
(GO:0021828)
Growth factor binding
(GO:0019838)
Gtpase activator activity
(GO:0005096)
Heart development
(GO:0007507)
Heparin binding
(GO:0008201)
Hepatocyte growth factor receptor signaling pathway
(GO:0048012)
Integrin-mediated signaling pathway
(GO:0007229)
Metal ion binding
(GO:0046872)
Motor neuron axon guidance
(GO:0008045)
Multicellular organism development
(GO:0007275)
Negative regulation of axon extension
(GO:0030517)
Negative regulation of axon extension involved in axon guidance
(GO:0048843)
Negative regulation of neuron apoptotic process
(GO:0043524)
Nervous system development
(GO:0007399)
Neural crest cell migration
(GO:0001755)
Neuron development
(GO:0048666)
Neuron migration
(GO:0001764)
Neuropilin signaling pathway
(GO:0038189)
Outflow tract septum morphogenesis
(GO:0003148)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of axon extension involved in axon guidance
(GO:0048842)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phosphorylation
(GO:0042327)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of axon extension involved in axon guidance
(GO:0048841)
Regulation of cdc42 protein signal transduction
(GO:0032489)
Regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030947)
Response to wounding
(GO:0009611)
Retinal ganglion cell axon guidance
(GO:0031290)
Semaphorin receptor activity
(GO:0017154)
Sprouting angiogenesis
(GO:0002040)
Substrate-dependent cell migration, cell extension
(GO:0006930)
Symbiont entry into host cell
(GO:0046718)
Sympathetic nervous system development
(GO:0048485)
Trigeminal nerve morphogenesis
(GO:0021636)
Trigeminal nerve structural organization
(GO:0021637)
Vascular endothelial growth factor binding
(GO:0038085)
Vascular endothelial growth factor receptor activity
(GO:0005021)
Vascular endothelial growth factor receptor signaling pathway
(GO:0048010)
Vascular endothelial growth factor signaling pathway
(GO:0038084)
Vasculogenesis
(GO:0001570)
Vegf-activated neuropilin signaling pathway
(GO:0038190)
Ventral trunk neural crest cell migration
(GO:0036486)
Vestibulocochlear nerve structural organization
(GO:0021649)

Other Information

Proteins

Neuropilin-1

Genular Protein ID: 3400826701

Symbol: NRP1_MOUSE

Name: Neuropilin-1

UniProtKB Accession Codes:

P97333 Q6PAR3

Database IDs:

Citations:

PubMed ID: 8748368

Title: Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous system.

PubMed ID: 8748368

DOI: 10.1002/(sici)1097-4695(199601)29:1<1::aid-neu1>3.0.co;2-f

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19656770

Title: The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation.

PubMed ID: 19656770

DOI: 10.1074/mcp.m900195-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20133938

Title: Neuropilin 1 directly interacts with Fer kinase to mediate semaphorin 3A-induced death of cortical neurons.

PubMed ID: 20133938

DOI: 10.1074/jbc.m109.080689

PubMed ID: 26503042

Title: CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.

PubMed ID: 26503042

DOI: 10.1038/nature15510

PubMed ID: 26789244

Title: Corrigendum: CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.

PubMed ID: 26789244

DOI: 10.1038/nature16499

PubMed ID: 30623799

Title: Neuropilin-1 Controls Endothelial Homeostasis by Regulating Mitochondrial Function and Iron-Dependent Oxidative Stress.

PubMed ID: 30623799

DOI: 10.1016/j.isci.2018.12.005

Sequence Information:

Length: 923
Mass: 103000
Checksum: 23209818C5C42137
Sequence:

MERGLPLLCA TLALALALAG AFRSDKCGGT IKIENPGYLT SPGYPHSYHP SEKCEWLIQA 
PEPYQRIMIN FNPHFDLEDR DCKYDYVEVI DGENEGGRLW GKFCGKIAPS PVVSSGPFLF 
IKFVSDYETH GAGFSIRYEI FKRGPECSQN YTAPTGVIKS PGFPEKYPNS LECTYIIFAP 
KMSEIILEFE SFDLEQDSNP PGGMFCRYDR LEIWDGFPEV GPHIGRYCGQ KTPGRIRSSS 
GVLSMVFYTD SAIAKEGFSA NYSVLQSSIS EDFKCMEALG MESGEIHSDQ ITASSQYGTN 
WSVERSRLNY PENGWTPGED SYKEWIQVDL GLLRFVTAVG TQGAISKETK KKYYVKTYRV 
DISSNGEDWI SLKEGNKAII FQGNTNPTDV VLGVFSKPLI TRFVRIKPVS WETGISMRFE 
VYGCKITDYP CSGMLGMVSG LISDSQITAS NQADRNWMPE NIRLVTSRTG WALPPSPHPY 
TNEWLQVDLG DEKIVRGVII QGGKHRENKV FMRKFKIAYS NNGSDWKTIM DDSKRKAKSF 
EGNNNYDTPE LRTFSPLSTR FIRIYPERAT HSGLGLRMEL LGCEVEAPTA GPTTPNGNPV 
DECDDDQANC HSGTGDDFQL TGGTTVLATE KPTIIDSTIQ SEFPTYGFNC EFGWGSHKTF 
CHWEHDSHAQ LRWSVLTSKT GPIQDHTGDG NFIYSQADEN QKGKVARLVS PVVYSQSSAH 
CMTFWYHMSG SHVGTLRVKL RYQKPEEYDQ LVWMVVGHQG DHWKEGRVLL HKSLKLYQVI 
FEGEIGKGNL GGIAVDDISI NNHISQEDCA KPTDLDKKNT EIKIDETGST PGYEGEGEGD 
KNISRKPGNV LKTLDPILIT IIAMSALGVL LGAVCGVVLY CACWHNGMSE RNLSALENYN 
FELVDGVKLK KDKLNPQSNY SEA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nrp1

Associated with

Other Information

Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous system. PubMed ID: 8748368

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation. PubMed ID: 19656770

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Neuropilin 1 directly interacts with Fer kinase to mediate semaphorin 3A-induced death of cortical neurons. PubMed ID: 20133938

CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. PubMed ID: 26503042

Corrigendum: CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. PubMed ID: 26789244

Neuropilin-1 Controls Endothelial Homeostasis by Regulating Mitochondrial Function and Iron-Dependent Oxidative Stress. PubMed ID: 30623799