Details for: Nsdhl

Gene ID: 18194

Symbol: Nsdhl

Ensembl ID: ENSMUSG00000031349

Description: NAD(P) dependent steroid dehydrogenase-like

Associated with

  • Cholesterol biosynthesis
    (R-MMU-191273)
  • Metabolism
    (R-MMU-1430728)
  • Metabolism of lipids
    (R-MMU-556833)
  • Metabolism of steroids
    (R-MMU-8957322)
  • 3-beta-hydroxy-delta5-steroid dehydrogenase activity
    (GO:0003854)
  • 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:nad(p)+ 3-oxidoreductase (decarboxylating) activity
    (GO:0103066)
  • 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:nad(p)+ 3-dehydrogenase (decarboxylating) activity
    (GO:0103067)
  • C-3 sterol dehydrogenase (c-4 sterol decarboxylase) activity
    (GO:0000252)
  • Cholesterol biosynthetic process
    (GO:0006695)
  • Cholesterol metabolic process
    (GO:0008203)
  • Endoplasmic reticulum
    (GO:0005783)
  • Hair follicle development
    (GO:0001942)
  • Labyrinthine layer blood vessel development
    (GO:0060716)
  • Lipid droplet
    (GO:0005811)
  • Lipid metabolic process
    (GO:0006629)
  • Membrane
    (GO:0016020)
  • Oxidoreductase activity
    (GO:0016491)
  • Oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
    (GO:0016616)
  • Smoothened signaling pathway
    (GO:0007224)
  • Steroid biosynthetic process
    (GO:0006694)
  • Steroid metabolic process
    (GO:0008202)
  • Sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity
    (GO:0047012)
  • Sterol biosynthetic process
    (GO:0016126)

Other Information

Genular Protein ID: 2478057297

Symbol: NSDHL_MOUSE

Name: Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

UniProtKB Accession Codes:

Q9R1J0 O55109

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEBI 51 ChiTaRS 1 DNASU 1 EC 3 EMBL 2 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 2 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 18 SMR 1 STRING 1 SUPFAM 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 10369263

Title: The gene mutated in bare patches and striated mice encodes a novel 3beta-hydroxysteroid dehydrogenase.

PubMed ID: 10369263

DOI: 10.1038/9700

PubMed ID: 10854409

Title: Comparative genome sequence analysis of the Bpa/Str region in mouse and man.

PubMed ID: 10854409

DOI: 10.1101/gr.10.6.758

PubMed ID: 14506130

Title: NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets.

PubMed ID: 14506130

DOI: 10.1093/hmg/ddg321

PubMed ID: 14567972

Title: Identification of two novel mutations in the murine Nsdhl sterol dehydrogenase gene and development of a functional complementation assay in yeast.

PubMed ID: 14567972

DOI: 10.1016/s1096-7192(03)00137-9

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23125191

Title: Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation.

PubMed ID: 23125191

DOI: 10.1158/2159-8290.cd-12-0031

Sequence Information:

  • Length: 362
  • Mass: 40686
  • Checksum: 4DB53EC0314885C3
  • Sequence:
    • MEQAVHGESK RGQVTGTHLT NDISKAKKCT VIGGSGFLGQ HMVEQLLERG YTVNVFDIHQ 
GFDNPRVQFF IGDLCNQQDL YPALKGVSTV FHCASPPPYS NNKELFYRVN FIGTKTVIET 
CREAGVQKLI LTSSASVVFE GVDIKNGTED LPYAMKPIDY YTETKILQER AVLDANDPKK 
NFLTAAIRPH GIFGPRDPQL VPILIDAARK GKMKFMIGNG ENLVDFTFVE NVVHGHILAA 
EHLSQDAALG GKAFHITNDE PIPFWTFLSR ILTGLNYEAP KYHIPYWMAY YLAFLLSLLV 
MVVSPLIQIQ PTFTPIRVAL AGTFHYYSCE KAKKLFGYRP LVTMDEAVER TVQSFHHLRK 
DK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.