Details for: Musk

Gene ID: 18198

Symbol: Musk

Ensembl ID: ENSMUSG00000057280

Description: muscle, skeletal, receptor tyrosine kinase

Associated with

Other Information

Genular Protein ID: 4052211524

Symbol: MUSK_MOUSE

Name: Muscle, skeletal receptor tyrosine-protein kinase

UniProtKB Accession Codes:

Q61006 Q61005 Q61987 Q61988

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CDD 4 CTD 1 ChEBI 8 ChiTaRS 1 DNASU 1 EC 2 ELM 1 EMBL 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 40 Gene3D 3 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 3 PaxDb 1 Pfam 3 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 4 Rhea 3 SMART 3 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 7624144

Title: Cloning and developmental expression of Nsk2, a novel receptor tyrosine kinase implicated in skeletal myogenesis.

PubMed ID: 7624144

PubMed ID: 8653786

Title: The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo.

PubMed ID: 8653786

DOI: 10.1016/s0092-8674(00)81251-9

PubMed ID: 8653787

Title: Agrin acts via a MuSK receptor complex.

PubMed ID: 8653787

DOI: 10.1016/s0092-8674(00)81252-0

PubMed ID: 11323662

Title: Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse.

PubMed ID: 11323662

DOI: 10.1038/35074025

PubMed ID: 12165471

Title: Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1.

PubMed ID: 12165471

DOI: 10.1016/s0896-6273(02)00783-3

PubMed ID: 12756238

Title: A novel pathway for MuSK to induce key genes in neuromuscular synapse formation.

PubMed ID: 12756238

DOI: 10.1083/jcb.200210156

PubMed ID: 14622576

Title: Implication of geranylgeranyltransferase I in synapse formation.

PubMed ID: 14622576

DOI: 10.1016/s0896-6273(03)00695-0

PubMed ID: 14678832

Title: A putative ariadne-like E3 ubiquitin ligase (PAUL) that interacts with the muscle-specific kinase (MuSK).

PubMed ID: 14678832

DOI: 10.1016/s1567-133x(03)00146-7

PubMed ID: 15340048

Title: A single pulse of agrin triggers a pathway that acts to cluster acetylcholine receptors.

PubMed ID: 15340048

DOI: 10.1128/mcb.24.18.7841-7854.2004

PubMed ID: 16818610

Title: Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction.

PubMed ID: 16818610

DOI: 10.1101/gad.375206

PubMed ID: 16794080

Title: The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.

PubMed ID: 16794080

DOI: 10.1126/science.1127142

PubMed ID: 17576800

Title: Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction.

PubMed ID: 17576800

DOI: 10.1083/jcb.200610060

PubMed ID: 18848351

Title: Lrp4 is a receptor for Agrin and forms a complex with MuSK.

PubMed ID: 18848351

DOI: 10.1016/j.cell.2008.10.002

PubMed ID: 18272689

Title: Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin.

PubMed ID: 18272689

DOI: 10.1523/jneurosci.4130-07.2008

PubMed ID: 19038220

Title: A mammalian homolog of Drosophila tumorous imaginal discs, Tid1, mediates agrin signaling at the neuromuscular junction.

PubMed ID: 19038220

DOI: 10.1016/j.neuron.2008.09.025

PubMed ID: 19940021

Title: Caveolin-3 promotes nicotinic acetylcholine receptor clustering and regulates neuromuscular junction activity.

PubMed ID: 19940021

DOI: 10.1091/mbc.e09-05-0381

PubMed ID: 20603078

Title: The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization.

PubMed ID: 20603078

DOI: 10.1016/j.molcel.2010.06.007

Sequence Information:

  • Length: 868
  • Mass: 96693
  • Checksum: AFE4E644C6869933
  • Sequence:
    • MRELVNIPLL QMLTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS 
WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCI ANNGVGGAVE SCGALQVKMK 
PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDNA LRENSRIAVL ESGSLRIHNV 
QKEDAGQYRC VAKNSLGTAY SKLVKLEVEV FARILRAPES HNVTFGSFVT LRCTAIGIPV 
PTISWIENGN AVSSGSIQES VKDRVIDSRL QLFITKPGLY TCIATNKHGE KFSTAKAAAT 
VSIAEWSKSQ KDSQGYCAQY RGEVCDAVLA KDALVFFNTS YRDPEDAQEL LIHTAWNELK 
AVSPLCRPAA EALLCNHLFQ ECSPGVVPTP MPICREYCLA VKELFCAKEW QAMEGKAHRG 
LYRSGMHLLP VPECSKLPSM HRDPTACTRL PYLDYKKENI TTFPSITSSR PSADIPNLPA 
STSSFAVSPA YSMTVIISIV SSFALFALLT IATLYCCRRR KEWKNKKRES TAVTLTTLPS 
ELLLDRLHPN PMYQRMPLLL NPKLLSLEYP RNNIEYVRDI GEGAFGRVFQ ARAPGLLPYE 
PFTMVAVKML KEEASADMQA DFQREAALMA EFDNPNIVKL LGVCAVGKPM CLLFEYMAYG 
DLNEFLRSMS PHTVCSLSHS DLSTRARVSS PGPPPLSCAE QLCIARQVAA GMAYLSERKF 
VHRDLATRNC LVGETMVVKI ADFGLSRNIY SADYYKADGN DAIPIRWMPP ESIFYNRYTT 
ESDVWAYGVV LWEIFSYGLQ PYYGMAHEEV IYYVRDGNIL ACPENCPLEL YNLMRLCWSK 
LPADRPSFCS IHRILQRMCE RAEGTVGV

Genular Protein ID: 486173419

Symbol: Q32S49_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q32S49

Database IDs:

AGR 1 ARBA 20 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 ExpressionAtlas 1 GO 5 Gene3D 3 Genevisible 1 HOGENOM 1 InterPro 14 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PRINTS 1 PROSITE 8 PROSITE-ProRule 2 Pfam 3 RefSeq 1 Rhea 3 SAM 2 SMART 3 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16146674

Title: Multiple alternatively spliced transcripts of the receptor tyrosine kinase MuSK are expressed in muscle.

PubMed ID: 16146674

DOI: 10.1016/j.gene.2005.07.009

Sequence Information:

  • Length: 860
  • Mass: 95671
  • Checksum: A837F8299BD7494C
  • Sequence:
    • MRELVNIPLL QMLTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS 
WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCI ANNGVGGAVE SCGALQVKMK 
PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDNA LRENSRIAVL ESGSLRIHNV 
QKEDAGQYRC VAKNSLGTAY SKLVKLEVEV FARILRAPES HNVTFGSFVT LRCTAIGIPV 
PTISWIENGN AVSSGSIQES VKDRVIDSRL QLFITKPGLY TCIATNKHGE KFSTAKAAAT 
VSIAEWSKSQ KDSQGYCAQY RGEVCDAVLA KDALVFFNTS YRDPEDAQEL LIHTAWNELK 
AVSPLCRPAA EALLCNHLFQ ECSPGVVPTP MPICREYCLA VKELFCAKEW QAMEGKAHRG 
LYRSGMHLLP VPECSKLPSM HRDPTACTRL PYLAFPSITS SRPSADIPNL PASTSSFAVS 
PAYSMTVIIS IVSSFALFAL LTIATLYCCR RRKEWKNKKR ESTAVTLTTL PSELLLDRLH 
PNPMYQRMPL LLNPKLLSLE YPRNNIEYVR DIGEGAFGRV FQARAPGLLP YEPFTMVAVK 
MLKEEASADM QADFQREAAL MAEFDNPNIV KLLGVCAVGK PMCLLFEYMA YGDLNEFLRS 
MSPHTVCSLS HSDLSTRARV SSPGPPPLSC AEQLCIARQV AAGMAYLSER KFVHRDLATR 
NCLVGETMVV KIADFGLSRN IYSADYYKAD GNDAIPIRWM PPESIFYNRY TTESDVWAYG 
VVLWEIFSYG LQPYYGMAHE EVIYYVRDGN ILACPENCPL ELYNLMRLCW SKLPADRPSF 
CSIHRILQRM CERAEGTVGV

Genular Protein ID: 1416024604

Symbol: E9PVV8_MOUSE

Name: N/A

UniProtKB Accession Codes:

E9PVV8

Database IDs:

AGR 1 ARBA 20 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 EC 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 3 GeneTree 1 Genevisible 1 InterPro 14 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PRINTS 1 PROSITE 8 PROSITE-ProRule 2 Pfam 3 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 3 SAM 2 SMART 3 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 893
  • Mass: 99684
  • Checksum: F3DD87BD9DAFF7F6
  • Sequence:
    • MRELVNIPLL QMLTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS 
WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCI ANNGVGGAVE SCGALQVKMK 
PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDNA LRENSRIAVL ESGSLRIHNV 
QKEDAGQYRC VAKNSLGTAY SKLVKLEVEE DREPEQDAKV FARILRAPES HNVTFGSFVT 
LRCTAIGIPV PTISWIENGN AVSSGSIQES VKDRVIDSRL QLFITKPGLY TCIATNKHGE 
KFSTAKAAAT VSIAVPPPWF SMDTSFLWTE WSKSQKDSQG YCAQYRGEVC DAVLAKDALV 
FFNTSYRDPE DAQELLIHTA WNELKAVSPL CRPAAEALLC NHLFQECSPG VVPTPMPICR 
EYCLAVKELF CAKEWQAMEG KAHRGLYRSG MHLLPVPECS KLPSMHRDPT ACTRLPYLDY 
KKENITTFPS ITSSRPSADI PNLPASTSSF AVSPAYSMTV IISIVSSFAL FALLTIATLY 
CCRRRKEWKN KKRESTAVTL TTLPSELLLD RLHPNPMYQR MPLLLNPKLL SLEYPRNNIE 
YVRDIGEGAF GRVFQARAPG LLPYEPFTMV AVKMLKEEAS ADMQADFQRE AALMAEFDNP 
NIVKLLGVCA VGKPMCLLFE YMAYGDLNEF LRSMSPHTVC SLSHSDLSTR ARVSSPGPPP 
LSCAEQLCIA RQVAAGMAYL SERKFVHRDL ATRNCLVGET MVVKIADFGL SRNIYSADYY 
KADGNDAIPI RWMPPESIFY NRYTTESDVW AYGVVLWEIF SYGLQPYYGM AHEEVIYYVR 
DGNILACPEN CPLELYNLMR LCWSKLPADR PSFCSIHRIL QRMCERAEGT VGV

Genular Protein ID: 431122164

Symbol: Q1XD56_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q1XD56

Database IDs:

AGR 1 ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 InterPro 8 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 1 UCSC 1

Citations:

PubMed ID: 16557298

Title: Induction of myasthenia by immunization against muscle-specific kinase.

PubMed ID: 16557298

DOI: 10.1172/JCI21545

Sequence Information:

  • Length: 464
  • Mass: 50991
  • Checksum: 3C1FA168787C7CD8
  • Sequence:
    • MRELVNIPLL QMLTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS 
WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCI ANNGVGGAVE SCGALQVKMK 
PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDNA LRENSRIAVL ESGSLRIHNV 
QKEDAGQYRC VAKNSLGTAY SKLVKLEVEV FARILRAPES HNVTFGSFVT LRCTAIGIPV 
PTISWIENGN AVSSGSIQES VKDRVIDSRL QLFITKPGLY TCIATNKHGE KFSTAKAAAT 
VSIAEWSKSQ KDSQGYCAQY RGEVCDAVLA KDALVFFNTS YRDPEDAQEL LIHTAWNELK 
AVSPLCRPAA EALLCNHLFQ ECSPGVVPTP MPICREYCLA VKELFCAKEW QAMEGKAHRG 
LYRSGMHLLP VPECSKLPSM HRDPTACTRL PYLGNKEVPP DFGS

Genular Protein ID: 2541729681

Symbol: Q32SD3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q32SD3

Database IDs:

AGR 1 ARBA 20 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 GO 5 Gene3D 3 Genevisible 1 InterPro 14 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PRINTS 1 PROSITE 8 PROSITE-ProRule 2 Pfam 3 PhylomeDB 1 RefSeq 1 Rhea 3 SAM 2 SMART 3 SUPFAM 2 UCSC 1

Citations:

PubMed ID: 16146674

Title: Multiple alternatively spliced transcripts of the receptor tyrosine kinase MuSK are expressed in muscle.

PubMed ID: 16146674

DOI: 10.1016/j.gene.2005.07.009

Sequence Information:

  • Length: 878
  • Mass: 97891
  • Checksum: 96EAF92EDDBDF30D
  • Sequence:
    • MRELVNIPLL QMLTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS 
WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCI ANNGVGGAVE SCGALQVKMK 
PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDNA LRENSRIAVL ESGSLRIHNV 
QKEDAGQYRC VAKNSLGTAY SKLVKLEVEE DREPEQDAKV FARILRAPES HNVTFGSFVT 
LRCTAIGIPV PTISWIENGN AVSSGSIQES VKDRVIDSRL QLFITKPGLY TCIATNKHGE 
KFSTAKAAAT VSIAEWSKSQ KDSQGYCAQY RGEVCDAVLA KDALVFFNTS YRDPEDAQEL 
LIHTAWNELK AVSPLCRPAA EALLCNHLFQ ECSPGVVPTP MPICREYCLA VKELFCAKEW 
QAMEGKAHRG LYRSGMHLLP VPECSKLPSM HRDPTACTRL PYLDYKKENI TTFPSITSSR 
PSADIPNLPA STSSFAVSPA YSMTVIISIV SSFALFALLT IATLYCCRRR KEWKNKKRES 
TAVTLTTLPS ELLLDRLHPN PMYQRMPLLL NPKLLSLEYP RNNIEYVRDI GEGAFGRVFQ 
ARAPGLLPYE PFTMVAVKML KEEASADMQA DFQREAALMA EFDNPNIVKL LGVCAVGKPM 
CLLFEYMAYG DLNEFLRSMS PHTVCSLSHS DLSTRARVSS PGPPPLSCAE QLCIARQVAA 
GMAYLSERKF VHRDLATRNC LVGETMVVKI ADFGLSRNIY SADYYKADGN DAIPIRWMPP 
ESIFYNRYTT ESDVWAYGVV LWEIFSYGLQ PYYGMAHEEV IYYVRDGNIL ACPENCPLEL 
YNLMRLCWSK LPADRPSFCS IHRILQRMCE RAEGTVGV

Genular Protein ID: 2384512515

Symbol: Q497X0_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q497X0

Database IDs:

AGR 1 ARBA 20 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 EC 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 3 GeneTree 1 InterPro 14 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PRINTS 1 PROSITE 8 PROSITE-ProRule 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 4 Rhea 3 SAM 2 SMART 3 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16146674

Title: Multiple alternatively spliced transcripts of the receptor tyrosine kinase MuSK are expressed in muscle.

PubMed ID: 16146674

DOI: 10.1016/j.gene.2005.07.009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 870
  • Mass: 96869
  • Checksum: 2350F300AF6DA75A
  • Sequence:
    • MRELVNIPLL QMLTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS 
WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCI ANNGVGGAVE SCGALQVKMK 
PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDNA LRENSRIAVL ESGSLRIHNV 
QKEDAGQYRC VAKNSLGTAY SKLVKLEVEE DREPEQDAKV FARILRAPES HNVTFGSFVT 
LRCTAIGIPV PTISWIENGN AVSSGSIQES VKDRVIDSRL QLFITKPGLY TCIATNKHGE 
KFSTAKAAAT VSIAEWSKSQ KDSQGYCAQY RGEVCDAVLA KDALVFFNTS YRDPEDAQEL 
LIHTAWNELK AVSPLCRPAA EALLCNHLFQ ECSPGVVPTP MPICREYCLA VKELFCAKEW 
QAMEGKAHRG LYRSGMHLLP VPECSKLPSM HRDPTACTRL PYLAFPSITS SRPSADIPNL 
PASTSSFAVS PAYSMTVIIS IVSSFALFAL LTIATLYCCR RRKEWKNKKR ESTAVTLTTL 
PSELLLDRLH PNPMYQRMPL LLNPKLLSLE YPRNNIEYVR DIGEGAFGRV FQARAPGLLP 
YEPFTMVAVK MLKEEASADM QADFQREAAL MAEFDNPNIV KLLGVCAVGK PMCLLFEYMA 
YGDLNEFLRS MSPHTVCSLS HSDLSTRARV SSPGPPPLSC AEQLCIARQV AAGMAYLSER 
KFVHRDLATR NCLVGETMVV KIADFGLSRN IYSADYYKAD GNDAIPIRWM PPESIFYNRY 
TTESDVWAYG VVLWEIFSYG LQPYYGMAHE EVIYYVRDGN ILACPENCPL ELYNLMRLCW 
SKLPADRPSF CSIHRILQRM CERAEGTVGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.