Details for: JAG1

Gene ID: 182

Symbol: JAG1

Ensembl ID: ENSG00000101384

Description: jagged canonical Notch ligand 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.38
    Marker Score: 3226
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.94
    Marker Score: 6080
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.67
    Marker Score: 3027
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.61
    Marker Score: 1524
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.58
    Marker Score: 2751
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.57
    Marker Score: 1391.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.28
    Marker Score: 2401
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.24
    Marker Score: 2415
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.2
    Marker Score: 2664
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.09
    Marker Score: 1487
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.89
    Marker Score: 920
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.79
    Marker Score: 2061
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.74
    Marker Score: 3278
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.7
    Marker Score: 1883
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.67
    Marker Score: 8192.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.61
    Marker Score: 3104.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.58
    Marker Score: 1707
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.52
    Marker Score: 591.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.47
    Marker Score: 2172
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.47
    Marker Score: 982
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.45
    Marker Score: 9260.5
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.44
    Marker Score: 1280.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.44
    Marker Score: 1491
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.42
    Marker Score: 10581
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.36
    Marker Score: 1445
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.28
    Marker Score: 317
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.23
    Marker Score: 2460.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.22
    Marker Score: 3266
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.22
    Marker Score: 280
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.2
    Marker Score: 1994
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.2
    Marker Score: 288
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.19
    Marker Score: 3727
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.17
    Marker Score: 10105
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.17
    Marker Score: 2939
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.16
    Marker Score: 766
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.14
    Marker Score: 387
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.12
    Marker Score: 671.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.11
    Marker Score: 38592
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.11
    Marker Score: 486
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.11
    Marker Score: 650
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.09
    Marker Score: 2579
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.09
    Marker Score: 1543
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.07
    Marker Score: 402
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.05
    Marker Score: 267
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.05
    Marker Score: 428
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251745
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.03
    Marker Score: 2345
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.02
    Marker Score: 579
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.02
    Marker Score: 960
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.01
    Marker Score: 842
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.01
    Marker Score: 236
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1
    Marker Score: 1638
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1
    Marker Score: 312
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.99
    Marker Score: 986
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.99
    Marker Score: 280
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.98
    Marker Score: 197
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.98
    Marker Score: 2297
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.97
    Marker Score: 1207
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.96
    Marker Score: 281
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5278
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2722
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.9
    Marker Score: 413
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.89
    Marker Score: 2182
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.89
    Marker Score: 266
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.88
    Marker Score: 3421
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.88
    Marker Score: 419
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.87
    Marker Score: 13682.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.87
    Marker Score: 1419
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.87
    Marker Score: 603
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5261
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.86
    Marker Score: 1250
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.85
    Marker Score: 2428
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.85
    Marker Score: 725
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.85
    Marker Score: 467.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.83
    Marker Score: 344
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 630
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.82
    Marker Score: 7207
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.81
    Marker Score: 6356.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.81
    Marker Score: 784
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.81
    Marker Score: 4870
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 323
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.79
    Marker Score: 256
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.78
    Marker Score: 10547
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.77
    Marker Score: 997
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.76
    Marker Score: 317
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.76
    Marker Score: 1607
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.76
    Marker Score: 240
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.76
    Marker Score: 345.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.76
    Marker Score: 422
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.75
    Marker Score: 505
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.75
    Marker Score: 364
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.75
    Marker Score: 194
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.74
    Marker Score: 664
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.73
    Marker Score: 1528
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 666

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Other Information

**Key characteristics:** * JAG1 is a transmembrane protein that is expressed in a variety of cell types. * It is a key component of the Notch signaling pathway. * It is involved in the regulation of epithelial cell growth and differentiation. * It is a target for inhibition by the tumor suppressor protein p53. **Pathways and functions:** * JAG1 is a key component of the Notch signaling pathway. * It is responsible for the regulation of epithelial cell growth and differentiation. * It is also involved in the regulation of the development of the kidney, the eye, and the nervous system. * JAG1 is a target for inhibition by the tumor suppressor protein p53. **Clinical significance:** * Mutations in the JAG1 gene have been linked to a number of human diseases, including kidney cancer, eye cancer, and neural tube defects. * JAG1 is a potential target for cancer therapy. * Inhibition of JAG1 has been shown to inhibit cancer growth in animal models. **Additional information:** * JAG1 is a member of the Notch signaling pathway, which is a complex network of signaling molecules that is involved in a variety of cellular processes, including cell growth, differentiation, and apoptosis. * The Notch signaling pathway is essential for the development and maintenance of the kidney, the eye, and the nervous system. * JAG1 is a key regulator of these tissues.

Genular Protein ID: 4165505339

Symbol: JAG1_HUMAN

Name: Protein jagged-1

UniProtKB Accession Codes:

P78504 A0AV43 B4DYR1 E9PCF9 O14902 O15122 Q15816

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 9 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 55 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 9 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 7 PRINTS 2 PRO 1 PROSITE 6 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 11 RefSeq 2 SAM 1 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9268641

Title: Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12.

PubMed ID: 9268641

DOI: 10.1006/geno.1997.4820

PubMed ID: 9207788

Title: Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1.

PubMed ID: 9207788

DOI: 10.1038/ng0797-243

PubMed ID: 9462510

Title: The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1.

PubMed ID: 9462510

DOI: 10.1016/s1074-7613(00)80457-4

PubMed ID: 10329626

Title: Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors.

PubMed ID: 10329626

DOI: 10.1093/emboj/18.10.2803

PubMed ID: 10079256

Title: Human ligands of the Notch receptor.

PubMed ID: 10079256

DOI: 10.1016/s0002-9440(10)65325-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8955070

Title: An antisense oligonucleotide to the notch ligand Jagged enhances fibroblast growth factor-induced angiogenesis in vitro.

PubMed ID: 8955070

DOI: 10.1074/jbc.271.51.32499

PubMed ID: 9207787

Title: Mutations in the human Jagged1 gene are responsible for Alagille syndrome.

PubMed ID: 9207787

DOI: 10.1038/ng0797-235

PubMed ID: 10978356

Title: JAGGED1 expression in human embryos: correlation with the Alagille syndrome phenotype.

PubMed ID: 10978356

DOI: 10.1136/jmg.37.9.658

PubMed ID: 19948535

Title: Comprehensive genotype-phenotype analysis in 230 patients with tetralogy of Fallot.

PubMed ID: 19948535

DOI: 10.1136/jmg.2009.070391

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 18660822

Title: A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition.

PubMed ID: 18660822

DOI: 10.1038/nsmb.1457

PubMed ID: 19586525

Title: Exon 6 of human JAG1 encodes a conserved structural unit.

PubMed ID: 19586525

DOI: 10.1186/1472-6807-9-43

PubMed ID: 9585603

Title: Spectrum and frequency of Jagged1 (JAG1) mutations in Alagille syndrome patients and their families.

PubMed ID: 9585603

DOI: 10.1086/301875

PubMed ID: 10220506

Title: Mutations in JAGGED1 gene are predominantly sporadic in Alagille syndrome.

PubMed ID: 10220506

DOI: 10.1016/s0016-5085(99)70017-x

PubMed ID: 10533065

Title: Jagged-1 mutation analysis in Italian Alagille syndrome patients.

PubMed ID: 10533065

DOI: 10.1002/(sici)1098-1004(199911)14:5<394::aid-humu5>3.0.co;2-1

PubMed ID: 11058898

Title: Jagged1 (JAG1) mutation detection in an Australian Alagille syndrome population.

PubMed ID: 11058898

DOI: 10.1002/1098-1004(200011)16:5<408::aid-humu5>3.0.co;2-9

PubMed ID: 11152664

Title: Familial tetralogy of Fallot caused by mutation in the Jagged1 gene.

PubMed ID: 11152664

DOI: 10.1093/hmg/10.2.163

PubMed ID: 11157803

Title: Defective intracellular transport and processing of JAG1 missense mutations in Alagille syndrome.

PubMed ID: 11157803

DOI: 10.1093/hmg/10.4.405

PubMed ID: 11139247

Title: Fifteen novel mutations in the JAGGED1 gene of patients with Alagille syndrome.

PubMed ID: 11139247

DOI: 10.1002/1098-1004(2001)17:1<72::aid-humu11>3.0.co;2-u

PubMed ID: 11180599

Title: Mutation analysis of Jagged1 (JAG1) in Alagille syndrome patients.

PubMed ID: 11180599

DOI: 10.1002/1098-1004(200102)17:2<151::aid-humu8>3.0.co;2-t

PubMed ID: 12022040

Title: Familial deafness, congenital heart defects, and posterior embryotoxon caused by cysteine substitution in the first epidermal-growth-factor-like domain of Jagged 1.

PubMed ID: 12022040

DOI: 10.1086/341327

PubMed ID: 12297837

Title: The significance of human Jagged 1 mutations detected in severe cases of extrahepatic biliary atresia.

PubMed ID: 12297837

DOI: 10.1053/jhep.2002.35820

PubMed ID: 12442286

Title: DHPLC mutation analysis of Jagged1 (JAG1) reveals six novel mutations in Australian Alagille syndrome patients.

PubMed ID: 12442286

DOI: 10.1002/humu.9095

PubMed ID: 12649809

Title: Conditional JAG1 mutation shows the developing heart is more sensitive than developing liver to JAG1 dosage.

PubMed ID: 12649809

DOI: 10.1086/374386

PubMed ID: 12497640

Title: Identification of 36 novel Jagged1 (JAG1) mutations in patients with Alagille syndrome.

PubMed ID: 12497640

DOI: 10.1002/humu.9102

PubMed ID: 15712272

Title: Twelve novel JAG1 gene mutations in Polish Alagille syndrome patients.

PubMed ID: 15712272

DOI: 10.1002/humu.9313

PubMed ID: 16575836

Title: Jagged1 (JAG1) mutations in Alagille syndrome: increasing the mutation detection rate.

PubMed ID: 16575836

DOI: 10.1002/humu.20310

PubMed ID: 23801938

Title: Alagille Syndrome: A new missense mutation detected by whole-exome sequencing in a case previously found to be negative by DHPLC and MLPA.

PubMed ID: 23801938

DOI: 10.1159/000347231

PubMed ID: 20437614

Title: Jagged1 (JAG1) mutations in patients with tetralogy of Fallot or pulmonic stenosis.

PubMed ID: 20437614

DOI: 10.1002/humu.21231

PubMed ID: 32065591

Title: Dominant mutations of the Notch ligand Jagged1 cause peripheral neuropathy.

PubMed ID: 32065591

DOI: 10.1172/jci128152

Sequence Information:

  • Length: 1218
  • Mass: 133799
  • Checksum: F36EE9FBF64DF162
  • Sequence:
    • MRSPRTRGRS GRPLSLLLAL LCALRAKVCG ASGQFELEIL SMQNVNGELQ NGNCCGGARN 
PGDRKCTRDE CDTYFKVCLK EYQSRVTAGG PCSFGSGSTP VIGGNTFNLK ASRGNDRNRI 
VLPFSFAWPR SYTLLVEAWD SSNDTVQPDS IIEKASHSGM INPSRQWQTL KQNTGVAHFE 
YQIRVTCDDY YYGFGCNKFC RPRDDFFGHY ACDQNGNKTC MEGWMGPECN RAICRQGCSP 
KHGSCKLPGD CRCQYGWQGL YCDKCIPHPG CVHGICNEPW QCLCETNWGG QLCDKDLNYC 
GTHQPCLNGG TCSNTGPDKY QCSCPEGYSG PNCEIAEHAC LSDPCHNRGS CKETSLGFEC 
ECSPGWTGPT CSTNIDDCSP NNCSHGGTCQ DLVNGFKCVC PPQWTGKTCQ LDANECEAKP 
CVNAKSCKNL IASYYCDCLP GWMGQNCDIN INDCLGQCQN DASCRDLVNG YRCICPPGYA 
GDHCERDIDE CASNPCLNGG HCQNEINRFQ CLCPTGFSGN LCQLDIDYCE PNPCQNGAQC 
YNRASDYFCK CPEDYEGKNC SHLKDHCRTT PCEVIDSCTV AMASNDTPEG VRYISSNVCG 
PHGKCKSQSG GKFTCDCNKG FTGTYCHENI NDCESNPCRN GGTCIDGVNS YKCICSDGWE 
GAYCETNIND CSQNPCHNGG TCRDLVNDFY CDCKNGWKGK TCHSRDSQCD EATCNNGGTC 
YDEGDAFKCM CPGGWEGTTC NIARNSSCLP NPCHNGGTCV VNGESFTCVC KEGWEGPICA 
QNTNDCSPHP CYNSGTCVDG DNWYRCECAP GFAGPDCRIN INECQSSPCA FGATCVDEIN 
GYRCVCPPGH SGAKCQEVSG RPCITMGSVI PDGAKWDDDC NTCQCLNGRI ACSKVWCGPR 
PCLLHKGHSE CPSGQSCIPI LDDQCFVHPC TGVGECRSSS LQPVKTKCTS DSYYQDNCAN 
ITFTFNKEMM SPGLTTEHIC SELRNLNILK NVSAEYSIYI ACEPSPSANN EIHVAISAED 
IRDDGNPIKE ITDKIIDLVS KRDGNSSLIA AVAEVRVQRR PLKNRTDFLV PLLSSVLTVA 
WICCLVTAFY WCLRKRRKPG SHTHSASEDN TTNNVREQLN QIKNPIEKHG ANTVPIKDYE 
NKNSKMSKIR THNSEVEEDD MDKHQQKARF AKQPAYTLVD REEKPPNGTP TKHPNWTNKQ 
DNRDLESAQS LNRMEYIV

Genular Protein ID: 3696007684

Symbol: Q99740_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99740

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 8 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SMART 4 SUPFAM 2

Citations:

PubMed ID: 7697721

Title: Jagged: a mammalian ligand that activates Notch1.

PubMed ID: 7697721

DOI: 10.1016/0092-8674(95)90294-5

PubMed ID: 8955070

Title: An antisense oligonucleotide to the notch ligand Jagged enhances fibroblast growth factor-induced angiogenesis in vitro.

PubMed ID: 8955070

DOI: 10.1074/jbc.271.51.32499

Sequence Information:

  • Length: 263
  • Mass: 28405
  • Checksum: E77235CBB360B620
  • Sequence:
    • ARNSSCLPNP CHNGGTCVVN GESFTCVCKE GWEGPICAQN TNDCSPHPCY NSGTCVDGDN 
WYRCECAPGF AGPDCRININ ECQSSPCAFG ATCVDEINGY RCVCPPGHSG AKCQEVSGRP 
CITMGSVIPD GAKWDDDCNT CQCLNGRIAC SKVWCGPRPC LLHKGHSECP SGQSCIPILD 
DQCFVHPCTG VGECRSSSLQ PVKTKCTSDS YYQDNCANIT FTFNKEMMSP GLTTEHICSE 
LRNLNILKIY GMMGTRSRKS LTK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.