Genular: Defining Cellular Identity and Function

Details for: Ntn1

Gene ID: 18208

Symbol: Ntn1

Ensembl ID: ENSMUSG00000020902

Description: netrin 1

Associated with

Actin cytoskeleton
(GO:0015629)
Animal organ morphogenesis
(GO:0009887)
Anterior/posterior axon guidance
(GO:0033564)
Apoptotic process
(GO:0006915)
Axon guidance
(GO:0007411)
Axonogenesis
(GO:0007409)
Basement membrane
(GO:0005604)
Cdc42 protein signal transduction
(GO:0032488)
Cell-cell adhesion
(GO:0098609)
Cell periphery
(GO:0071944)
Cell population proliferation
(GO:0008283)
Chemorepulsion of axon
(GO:0061643)
Collagen-containing extracellular matrix
(GO:0062023)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendrite development
(GO:0016358)
Extracellular matrix structural constituent
(GO:0005201)
Extracellular region
(GO:0005576)
Glial cell proliferation
(GO:0014009)
Inner ear morphogenesis
(GO:0042472)
Mammary gland development
(GO:0030879)
Mammary gland duct morphogenesis
(GO:0060603)
Motor neuron axon guidance
(GO:0008045)
Motor neuron migration
(GO:0097475)
Negative regulation of axon extension
(GO:0030517)
Neuron migration
(GO:0001764)
Nuclear migration
(GO:0007097)
Nucleoplasm
(GO:0005654)
Positive regulation of axon extension
(GO:0045773)
Positive regulation of cell motility
(GO:2000147)
Positive regulation of glial cell proliferation
(GO:0060252)
Protein binding
(GO:0005515)
Ras protein signal transduction
(GO:0007265)
Regulation of cell migration
(GO:0030334)
Regulation of glial cell migration
(GO:1903975)
Regulation of synapse assembly
(GO:0051963)
Substrate-dependent cell migration, cell extension
(GO:0006930)
Tissue development
(GO:0009888)

Other Information

Proteins

Netrin-1

Genular Protein ID: 2501477587

Symbol: NET1_MOUSE

Name: Netrin-1

UniProtKB Accession Codes:

O09118 B1ARR0 Q60832 Q9QY50

Database IDs:

Citations:

PubMed ID: 8978605

Title: Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system.

PubMed ID: 8978605

DOI: 10.1016/s0092-8674(00)81795-x

PubMed ID: 10381568

Title: Divergent properties of mouse netrins.

PubMed ID: 10381568

DOI: 10.1016/s0925-4773(99)00035-0

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7604039

Title: Capturing genes encoding membrane and secreted proteins important for mouse development.

PubMed ID: 7604039

DOI: 10.1073/pnas.92.14.6592

PubMed ID: 18585357

Title: DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1.

PubMed ID: 18585357

DOI: 10.1016/j.cell.2008.05.030

PubMed ID: 27068745

Title: An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid beta Precursor Protein Signaling.

PubMed ID: 27068745

DOI: 10.1074/jbc.m115.698092

PubMed ID: 28483977

Title: Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.

PubMed ID: 28483977

DOI: 10.1523/jneurosci.2617-16.2017

Sequence Information:

Length: 604
Mass: 67810
Checksum: 135120DB6F0482F3
Sequence:

MMRAVWEALA ALAAVACLVG AVRGGPGLSM FAGQAAQPDP CSDENGHPRR CIPDFVNAAF 
GKDVRVSSTC GRPPARYCVV SERGEERLRS CHLCNSSDPK KAHPPAFLTD LNNPHNLTCW 
QSENYLQFPH NVTLTLSLGK KFEVTYVSLQ FCSPRPESMA IYKSMDYGRT WVPFQFYSTQ 
CRKMYNRPHR APITKQNEQE AVCTDSHTDM RPLSGGLIAF STLDGRPSAH DFDNSPVLQD 
WVTATDIRVA FSRLHTFGDE NEDDSELARD SYYYAVSDLQ VGGRCKCNGH AARCVRDRDD 
SLVCDCRHNT AGPECDRCKP FHYDRPWQRA TAREANECVA CNCNLHARRC RFNMELYKLS 
GRKSGGVCLN CRHNTAGRHC HYCKEGFYRD MGKPITHRKA CKACDCHPVG AAGKTCNQTT 
GQCPCKDGVT GITCNRCAKG YQQSRSPIAP CIKIPVAPPT TAASSVEEPE DCDSYCKASK 
GKLKMNMKKY CRKDYAVQIH ILKADKAGDW WKFTVNIISV YKQGTSRIRR GDQSLWIRSR 
DIACKCPKIK PLKKYLLLGN AEDSPDQSGI VADKSSLVIQ WRDTWARRLR KFQQREKKGK 
CKKA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ntn1

Associated with

Other Information

Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. PubMed ID: 8978605

Divergent properties of mouse netrins. PubMed ID: 10381568

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Capturing genes encoding membrane and secreted proteins important for mouse development. PubMed ID: 7604039

DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. PubMed ID: 18585357

An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid beta Precursor Protein Signaling. PubMed ID: 27068745

Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion. PubMed ID: 28483977