Genular: Defining Cellular Identity and Function

Details for: Ntrk1

Gene ID: 18211

Symbol: Ntrk1

Ensembl ID: ENSMUSG00000028072

Description: neurotrophic tyrosine kinase, receptor, type 1

Associated with

Activation of trka receptors
(R-MMU-187015)
Arms-mediated activation
(R-MMU-170984)
Frs2-mediated activation
(R-MMU-170968)
Pi3k/akt activation
(R-MMU-198203)
Prolonged erk activation events
(R-MMU-169893)
Retrograde neurotrophin signalling
(R-MMU-177504)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrks
(R-MMU-166520)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signalling to erks
(R-MMU-187687)
Signal transduction
(R-MMU-162582)
Trka activation by ngf
(R-MMU-187042)
Atp binding
(GO:0005524)
Axon
(GO:0030424)
Axon guidance
(GO:0007411)
Axonogenesis involved in innervation
(GO:0060385)
B cell differentiation
(GO:0030183)
Behavioral response to formalin induced pain
(GO:0061368)
Cell differentiation
(GO:0030154)
Cell surface
(GO:0009986)
Cellular response to growth factor stimulus
(GO:0071363)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Cellular response to nicotine
(GO:0071316)
Circadian rhythm
(GO:0007623)
Cytoplasm
(GO:0005737)
Detection of mechanical stimulus involved in sensory perception of pain
(GO:0050966)
Detection of temperature stimulus involved in sensory perception of pain
(GO:0050965)
Early endosome
(GO:0005769)
Endosome
(GO:0005768)
Gpi-linked ephrin receptor activity
(GO:0005004)
Identical protein binding
(GO:0042802)
Innervation
(GO:0060384)
Kinase activity
(GO:0016301)
Kinase binding
(GO:0019900)
Late endosome
(GO:0005770)
Learning or memory
(GO:0007611)
Mechanoreceptor differentiation
(GO:0042490)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of neuron apoptotic process
(GO:0043524)
Nerve growth factor binding
(GO:0048406)
Nerve growth factor receptor activity
(GO:0010465)
Nerve growth factor signaling pathway
(GO:0038180)
Nervous system development
(GO:0007399)
Neuron apoptotic process
(GO:0051402)
Neuron development
(GO:0048666)
Neuron projection development
(GO:0031175)
Neurotrophin binding
(GO:0043121)
Neurotrophin p75 receptor binding
(GO:0005166)
Neurotrophin receptor activity
(GO:0005030)
Neurotrophin trk receptor signaling pathway
(GO:0048011)
Nucleotide binding
(GO:0000166)
Peptidyl-tyrosine autophosphorylation
(GO:0038083)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of programmed cell death
(GO:0043068)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of ras protein signal transduction
(GO:0046579)
Positive regulation of synapse assembly
(GO:0051965)
Positive regulation of synaptic transmission, glutamatergic
(GO:0051968)
Programmed cell death involved in cell development
(GO:0010623)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051896)
Response to activity
(GO:0014823)
Response to electrical stimulus
(GO:0051602)
Response to nicotine
(GO:0035094)
Response to nutrient levels
(GO:0031667)
Response to xenobiotic stimulus
(GO:0009410)
Sertoli cell development
(GO:0060009)
Sympathetic nervous system development
(GO:0048485)
Transferase activity
(GO:0016740)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

High affinity nerve growth factor receptor

Genular Protein ID: 668153479

Symbol: NTRK1_MOUSE

Name: High affinity nerve growth factor receptor

UniProtKB Accession Codes:

Q3UFB7

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 8145823

Title: Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.

PubMed ID: 8145823

DOI: 10.1038/368246a0

PubMed ID: 8815902

Title: TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo.

PubMed ID: 8815902

DOI: 10.1523/jneurosci.16-19-06208.1996

PubMed ID: 16113645

Title: p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation.

PubMed ID: 16113645

DOI: 10.1038/sj.embor.7400503

PubMed ID: 16223723

Title: SLAM-associated protein as a potential negative regulator in Trk signaling.

PubMed ID: 16223723

DOI: 10.1074/jbc.m506554200

PubMed ID: 21816277

Title: Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival.

PubMed ID: 21816277

DOI: 10.1016/j.cell.2011.07.008

PubMed ID: 23785138

Title: p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks.

PubMed ID: 23785138

DOI: 10.1523/jneurosci.2757-12.2013

Sequence Information:

Length: 799
Mass: 87738
Checksum: 1A37F76A63564603
Sequence:

MLRGQRLGQL GWHRPAAGLG SLMTSLMLAC ASAASCREVC CPVGPSGLRC TRAGSLDTLR 
GLRGAGNLTE LYVENQQHLQ RLEFEDLQGL GELRSLTIVK SGLRFVAPDA FRFTPRLSHL 
NLSSNALESL SWKTVQGLSL QDLTLSGNPL HCSCALFWLQ RWEQEGLCGV HTQTLHDSGP 
GDQFLPLGHN TSCGVPTVKI QMPNDSVEVG DDVFLQCQVE GLALQQADWI LTELEGAATV 
KKFGDLPSLG LILVNVTSDL NKKNVTCWAE NDVGRAEVSV QVSVSFPASV HLGLAVEQHH 
WCIPFSVDGQ PAPSLRWLFN GSVLNETSFI FTQFLESALT NETMRHGCLR LNQPTHVNNG 
NYTLLAANPY GQAAASVMAA FMDNPFEFNP EDPIPVSFSP VDGNSTSRDP VEKKDETPFG 
VSVAVGLAVS AALFLSALLL VLNKCGQRSK FGINRPAVLA PEDGLAMSLH FMTLGGSSLS 
PTEGKGSGLQ GHIMENPQYF SDTCVHHIKR QDIILKWELG EGAFGKVFLA ECYNLLNDQD 
KMLVAVKALK EASENARQDF QREAELLTML QHQHIVRFFG VCTEGGPLLM VFEYMRHGDL 
NRFLRSHGPD AKLLAGGEDV APGPLGLGQL LAVASQVAAG MVYLASLHFV HRDLATRNCL 
VGQGLVVKIG DFGMSRDIYS TDYYRVGGRT MLPIRWMPPE SILYRKFSTE SDVWSFGVVL 
WEIFTYGKQP WYQLSNTEAI ECITQGRELE RPRACPPDVY AIMRGCWQRE PQQRLSMKDV 
HARLQALAQA PPSYLDVLG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ntrk1

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. PubMed ID: 8145823

TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo. PubMed ID: 8815902

p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation. PubMed ID: 16113645

SLAM-associated protein as a potential negative regulator in Trk signaling. PubMed ID: 16223723

Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival. PubMed ID: 21816277

p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. PubMed ID: 23785138