Details for: Ntrk2

Gene ID: 18212

Symbol: Ntrk2

Ensembl ID: ENSMUSG00000055254

Description: neurotrophic tyrosine kinase, receptor, type 2

Associated with

Other Information

Genular Protein ID: 2762318361

Symbol: NTRK2_MOUSE

Name: BDNF/NT-3 growth factors receptor

UniProtKB Accession Codes:

P15209 Q3TUF9 Q80WU0 Q91XJ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CDD 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 EC 1 EMBL 6 Ensembl 4 ExpressionAtlas 1 GO 76 Gene3D 3 GeneTree 1 Genevisible 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 20 KEGG 1 MGI 2 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 3 PRO 1 PROSITE 5 PROSITE-ProRule 3 PaxDb 1 PeptideAtlas 1 Pfam 4 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 3 RefSeq 7 Rhea 3 SAM 1 SMART 5 SMR 1 STRING 1 SUPFAM 3 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2555172

Title: trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

PubMed ID: 2555172

DOI: 10.1002/j.1460-2075.1989.tb08545.x

PubMed ID: 2160854

Title: The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain.

PubMed ID: 2160854

DOI: 10.1016/0092-8674(90)90476-u

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9148911

Title: TrkB variants with deletions in the leucine-rich motifs of the extracellular domain.

PubMed ID: 9148911

DOI: 10.1074/jbc.272.20.13019

PubMed ID: 1645620

Title: The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor.

PubMed ID: 1645620

DOI: 10.1016/0092-8674(91)90396-g

PubMed ID: 8402890

Title: Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death.

PubMed ID: 8402890

DOI: 10.1016/s0092-8674(05)80088-1

PubMed ID: 9728914

Title: Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo.

PubMed ID: 9728914

DOI: 10.1016/s0896-6273(00)80542-5

PubMed ID: 10571233

Title: Essential role for TrkB receptors in hippocampus-mediated learning.

PubMed ID: 10571233

DOI: 10.1016/s0896-6273(00)80853-3

PubMed ID: 12367511

Title: Mechanism of TrkB-mediated hippocampal long-term potentiation.

PubMed ID: 12367511

DOI: 10.1016/s0896-6273(02)00942-x

PubMed ID: 14581459

Title: Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx.

PubMed ID: 14581459

DOI: 10.1083/jcb.200305134

PubMed ID: 14603320

Title: Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells.

PubMed ID: 14603320

DOI: 10.1038/nature01983

PubMed ID: 15372074

Title: TrkB regulates neocortex formation through the Shc/PLCgamma-mediated control of neuronal migration.

PubMed ID: 15372074

DOI: 10.1038/sj.emboj.7600399

PubMed ID: 15329723

Title: Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB.

PubMed ID: 15329723

DOI: 10.1038/nature02765

PubMed ID: 16113645

Title: p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation.

PubMed ID: 16113645

DOI: 10.1038/sj.embor.7400503

PubMed ID: 16223723

Title: SLAM-associated protein as a potential negative regulator in Trk signaling.

PubMed ID: 16223723

DOI: 10.1074/jbc.m506554200

PubMed ID: 16801538

Title: TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology.

PubMed ID: 16801538

DOI: 10.1073/pnas.0603914103

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21849472

Title: Retrolinkin cooperates with endophilin A1 to mediate BDNF-TrkB early endocytic trafficking and signaling from early endosomes.

PubMed ID: 21849472

DOI: 10.1091/mbc.e11-04-0308

PubMed ID: 21414899

Title: TrkB (tropomyosin-related kinase B) controls the assembly and maintenance of GABAergic synapses in the cerebellar cortex.

PubMed ID: 21414899

DOI: 10.1523/jneurosci.4991-10.2011

PubMed ID: 23785138

Title: p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks.

PubMed ID: 23785138

DOI: 10.1523/jneurosci.2757-12.2013

PubMed ID: 23977241

Title: SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF.

PubMed ID: 23977241

DOI: 10.1371/journal.pone.0072164

PubMed ID: 27457814

Title: SorCS2 is required for BDNF-dependent plasticity in the hippocampus.

PubMed ID: 27457814

DOI: 10.1038/mp.2016.108

Sequence Information:

  • Length: 821
  • Mass: 92133
  • Checksum: 50E08D5FF86D8F30
  • Sequence:
    • MSPWLKWHGP AMARLWGLCL LVLGFWRASL ACPTSCKCSS ARIWCTEPSP GIVAFPRLEP 
NSVDPENITE ILIANQKRLE IINEDDVEAY VGLRNLTIVD SGLKFVAYKA FLKNSNLRHI 
NFTRNKLTSL SRRHFRHLDL SDLILTGNPF TCSCDIMWLK TLQETKSSPD TQDLYCLNES 
SKNMPLANLQ IPNCGLPSAR LAAPNLTVEE GKSVTLSCSV GGDPLPTLYW DVGNLVSKHM 
NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH 
WCIPFTVRGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYT 
LMAKNEYGKD ERQISAHFMG RPGVDYETNP NYPEVLYEDW TTPTDIGDTT NKSNEIPSTD 
VADQSNREHL SVYAVVVIAS VVGFCLLVML LLLKLARHSK FGMKGPASVI SNDDDSASPL 
HHISNGSNTP SSSEGGPDAV IIGMTKIPVI ENPQYFGITN SQLKPDTFVQ HIKRHNIVLK 
RELGEGAFGK VFLAECYNLC PEQDKILVAV KTLKDASDNA RKDFHREAEL LTNLQHEHIV 
KFYGVCVEGD PLIMVFEYMK HGDLNKFLRA HGPDAVLMAE GNPPTELTQS QMLHIAQQIA 
AGMVYLASQH FVHRDLATRN CLVGENLLVK IGDFGMSRDV YSTDYYRVGG HTMLPIRWMP 
PESIMYRKFT TESDVWSLGV VLWEIFTYGK QPWYQLSNNE VIECITQGRV LQRPRTCPQE 
VYELMLGCWQ REPHTRKNIK SIHTLLQNLA KASPVYLDIL G

Genular Protein ID: 3954981909

Symbol: Q3UHE3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UHE3

Database IDs:

AGR 1 ARBA 2 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 5 Gene3D 2 Genevisible 1 HOGENOM 1 InterPro 13 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 Pfam 3 RefSeq 3 SAM 2 SMART 4 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 476
  • Mass: 53186
  • Checksum: 20A8B375ED397ACE
  • Sequence:
    • MSPWLKWHGP AMARLWGLCL LVLGFWRASL ACPTSCKCSS ARIWCTEPSP GIVAFPRLEP 
NSVDPENITE ILIANQKRLE IINEDDVEAY VGLRNLTIVD SGLKFVAYKA FLKNSNLRHI 
NFTRNKLTSL SRRHFRHLDL SDLILTGNPF TCSCDIMWLK TLQETKSSPD TQDLYCLNES 
SKNMPLANLQ IPNCGLPSAR LAAPNLTVEE GKSVTLSCSV GGDPLPTLYW DVGNLVSKHM 
NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH 
WCIPFTVRGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYT 
LMAKNEYGKD ERQISAHFMG RPGVDYETNP NYPEVLYEDW TTPTDIGDTT NKSNEIPSTD 
VADQSNREHL SVYAVVVIAS VVGFCLLVML LLLKLARHSK FGMKGFVLFH KIPLDG

Genular Protein ID: 3539249796

Symbol: A0A286YDA3_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A286YDA3

Database IDs:

AGR 1 ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneTree 1 InterPro 13 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 4 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 492
  • Mass: 55182
  • Checksum: 106C8AC135CB2CA6
  • Sequence:
    • MSPWLKWHGP AMARLWGLCL LVLGFWRASL ACPTSCKCSS ARIWCTEPSP GIVAFPRLEP 
NSVDPENITE ILIANQKRLE IINEDDVEAY VGLRNLTIVD SGLKFVAYKA FLKNSNLRHI 
NFTRNKLTSL SRRHFRHLDL SDLILTGNPF TCSCDIMWLK TLQETKSSPD TQDLYCLNES 
SKNMPLANLQ IPNCGLPSAR LAAPNLTVEE GKSVTLSCSV GGDPLPTLYW DVGNLVSKHM 
NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH 
WCIPFTVRGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYT 
LMAKNEYGKD ERQISAHFMG RPGVDYETNP NYPEVLYEDW TTPTDIGDTT NKSNEIPSTD 
VADQSNREHL SVYAVVVIAS VVGFCLLVML LLLKLARHSK FGMKGGSGWI YDDWFLRLRN 
SSKDMILHIK TE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.