Details for: Ddr2

Gene ID: 18214

Symbol: Ddr2

Ensembl ID: ENSMUSG00000026674

Description: discoidin domain receptor family, member 2

Associated with

  • Extracellular matrix organization
    (R-MMU-1474244)
  • Non-integrin membrane-ecm interactions
    (R-MMU-3000171)
  • Actin cytoskeleton
    (GO:0015629)
  • Apical plasma membrane
    (GO:0016324)
  • Atp binding
    (GO:0005524)
  • Biomineral tissue development
    (GO:0031214)
  • Chondrocyte proliferation
    (GO:0035988)
  • Collagen-activated tyrosine kinase receptor signaling pathway
    (GO:0038063)
  • Collagen binding
    (GO:0005518)
  • Collagen fibril organization
    (GO:0030199)
  • Endochondral bone growth
    (GO:0003416)
  • Kinase activity
    (GO:0016301)
  • Membrane
    (GO:0016020)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of hydrogen peroxide-mediated programmed cell death
    (GO:1901299)
  • Nucleotide binding
    (GO:0000166)
  • Ossification
    (GO:0001503)
  • Peptidyl-tyrosine phosphorylation
    (GO:0018108)
  • Phosphorylation
    (GO:0016310)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of collagen biosynthetic process
    (GO:0032967)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of extracellular matrix disassembly
    (GO:0090091)
  • Positive regulation of fibroblast migration
    (GO:0010763)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of g1/s transition of mitotic cell cycle
    (GO:1900087)
  • Positive regulation of hepatic stellate cell activation
    (GO:2000491)
  • Positive regulation of hepatic stellate cell proliferation
    (GO:1904899)
  • Positive regulation of kinase activity
    (GO:0033674)
  • Positive regulation of neuron projection development
    (GO:0010976)
  • Positive regulation of osteoblast differentiation
    (GO:0045669)
  • Positive regulation of protein kinase activity
    (GO:0045860)
  • Positive regulation of vascular associated smooth muscle cell migration
    (GO:1904754)
  • Positive regulation of vascular associated smooth muscle cell proliferation
    (GO:1904707)
  • Positive regulation of wound healing
    (GO:0090303)
  • Protein autophosphorylation
    (GO:0046777)
  • Protein kinase activity
    (GO:0004672)
  • Protein phosphorylation
    (GO:0006468)
  • Protein tyrosine kinase activity
    (GO:0004713)
  • Protein tyrosine kinase collagen receptor activity
    (GO:0038062)
  • Receptor complex
    (GO:0043235)
  • Regulation of bone mineralization
    (GO:0030500)
  • Regulation of tissue remodeling
    (GO:0034103)
  • Transferase activity
    (GO:0016740)
  • Transmembrane receptor protein tyrosine kinase activity
    (GO:0004714)
  • Transmembrane receptor protein tyrosine kinase signaling pathway
    (GO:0007169)

Other Information

Genular Protein ID: 1215716876

Symbol: DDR2_MOUSE

Name: Discoidin domain-containing receptor 2

UniProtKB Accession Codes:

Q62371 B2RSD7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 EC 2 EMBL 3 Ensembl 3 ExpressionAtlas 1 GO 40 Gene3D 3 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 9 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 3 PaxDb 1 PeptideAtlas 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 3 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8247548

Title: Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain.

PubMed ID: 8247548

PubMed ID: 8108131

Title: Structure and expression of the Tyro 10 receptor tyrosine kinase.

PubMed ID: 8108131

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11375938

Title: The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism.

PubMed ID: 11375938

DOI: 10.1093/embo-reports/kve094

PubMed ID: 11723120

Title: Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2.

PubMed ID: 11723120

DOI: 10.1074/jbc.m107571200

PubMed ID: 11884411

Title: Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen.

PubMed ID: 11884411

DOI: 10.1074/jbc.m201078200

PubMed ID: 15509586

Title: Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice.

PubMed ID: 15509586

DOI: 10.1074/jbc.m411036200

PubMed ID: 18483174

Title: A novel dwarfism with gonadal dysfunction due to loss-of-function allele of the collagen receptor gene, Ddr2, in the mouse.

PubMed ID: 18483174

DOI: 10.1210/me.2007-0310

PubMed ID: 19681157

Title: Discoidin domain receptor 2 (DDR2) is required for maintenance of spermatogenesis in male mice.

PubMed ID: 19681157

DOI: 10.1002/mrd.21093

Sequence Information:

  • Length: 854
  • Mass: 96482
  • Checksum: 45CFD2BE9ED524D4
  • Sequence:
    • MIPIPRMPLV LLLLLLILGS AKAQVNPAIC RYPLGMSGGH IPDEDITASS QWSESTAAKY 
GRLDSEEGDG AWCPEIPVQP DDLKEFLQID LRTLHFITLV GTQGRHAGGH GIEFAPMYKI 
NYSRDGSRWI SWRNRHGKQV LDGNSNPYDV FLKDLEPPIV ARFVRLIPVT DHSMNVCMRV 
ELYGCVWLDG LVSYNAPAGQ QFVLPGGSII YLNDSVYDGA VGYSMTEGLG QLTDGVSGLD 
DFTQTHEYHV WPGYDYVGWR NESATNGFIE IMFEFDRIRN FTTMKVHCNN MFAKGVKIFK 
EVQCYFRSEA SEWEPTAVYF PLVLDDVNPS ARFVTVPLHH RMASAIKCQY HFADTWMMFS 
EITFQSDAAM YNNSGALPTS PMAPTTYDPM LKVDDSNTRI LIGCLVAIIF ILLAIIVIIL 
WRQFWQKMLE KASRRMLDDE MTVSLSLPSE SSMFNNNRSS SPSEQESNST YDRIFPLRPD 
YQEPSRLIRK LPEFAPGEEE SGCSGVVKPA QPNGPEGVPH YAEADIVNLQ GVTGGNTYCV 
PAVTMDLLSG KDVAVEEFPR KLLAFKEKLG EGQFGEVHLC EVEGMEKFKD KDFALDVSAN 
QPVLVAVKML RADANKNARN DFLKEIKIMS RLKDPNIIRL LAVCITEDPL CMITEYMENG 
DLNQFLSRHE PLSSCSSDAT VSYANLKFMA TQIASGMKYL SSLNFVHRDL ATRNCLVGKN 
YTIKIADFGM SRNLYSGDYY RIQGRAVLPI RWMSWESILL GKFTTASDVW AFGVTLWETF 
TFCQEQPYSQ LSDEQVIENT GEFFRDQGRQ IYLPQPALCP DSVYKLMLSC WRRETKHRPS 
FQEIHLLLLQ QGAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.