Genular: Defining Cellular Identity and Function

Details for: Numb

Gene ID: 18222

Symbol: Numb

Ensembl ID: ENSMUSG00000021224

Description: NUMB endocytic adaptor protein

Associated with

Axon guidance
(R-MMU-422475)
Degradation of gli1 by the proteasome
(R-MMU-5610780)
Developmental biology
(R-MMU-1266738)
Hedgehog 'off' state
(R-MMU-5610787)
Hedgehog 'on' state
(R-MMU-5632684)
L1cam interactions
(R-MMU-373760)
Recycling pathway of l1
(R-MMU-437239)
Signaling by hedgehog
(R-MMU-5358351)
Signal transduction
(R-MMU-162582)
Adherens junction organization
(GO:0034332)
Alpha-catenin binding
(GO:0045294)
Apical part of cell
(GO:0045177)
Apical plasma membrane
(GO:0016324)
Axonogenesis
(GO:0007409)
Basolateral plasma membrane
(GO:0016323)
Beta-catenin binding
(GO:0008013)
Cadherin binding
(GO:0045296)
Clathrin-coated pit
(GO:0005905)
Clathrin-coated vesicle
(GO:0030136)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Dendritic spine
(GO:0043197)
Early endosome
(GO:0005769)
Endosome
(GO:0005768)
Forebrain development
(GO:0030900)
Glutamatergic synapse
(GO:0098978)
Lateral ventricle development
(GO:0021670)
Lung epithelial cell differentiation
(GO:0060487)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative regulation of notch signaling pathway
(GO:0045746)
Negative regulation of protein localization to plasma membrane
(GO:1903077)
Nervous system development
(GO:0007399)
Neuroblast division in subventricular zone
(GO:0021849)
Neuroblast proliferation
(GO:0007405)
Plasma membrane
(GO:0005886)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of dendrite morphogenesis
(GO:0050775)
Positive regulation of neurogenesis
(GO:0050769)
Positive regulation of polarized epithelial cell differentiation
(GO:0030862)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Regulation of neuron differentiation
(GO:0045664)
Regulation of postsynapse assembly
(GO:0150052)
Regulation of postsynaptic neurotransmitter receptor internalization
(GO:0099149)

Other Information

Proteins

Protein numb homolog

Genular Protein ID: 3459018408

Symbol: NUMB_MOUSE

Name: Protein numb homolog

UniProtKB Accession Codes:

Q9QZS3 P70422 Q8CIB1 Q9DC57 Q9QZR1 Q9QZS4

Database IDs:

Citations:

PubMed ID: 8755477

Title: Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis.

PubMed ID: 8755477

DOI: 10.1016/s0896-6273(00)80279-2

PubMed ID: 10551880

Title: Characterization of four mammalian Numb protein isoforms: Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain.

PubMed ID: 10551880

DOI: 10.1074/jbc.274.46.33097

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9535908

Title: The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX.

PubMed ID: 9535908

DOI: 10.1074/jbc.273.15.9179

PubMed ID: 10841580

Title: Mouse numb is an essential gene involved in cortical neurogenesis.

PubMed ID: 10841580

DOI: 10.1073/pnas.97.12.6844

PubMed ID: 11782429

Title: LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation.

PubMed ID: 11782429

DOI: 10.1093/emboj/21.1.93

PubMed ID: 12410312

Title: Progenitor cell maintenance requires numb and numblike during mouse neurogenesis.

PubMed ID: 12410312

DOI: 10.1038/nature01124

PubMed ID: 15273690

Title: Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis.

PubMed ID: 15273690

DOI: 10.1038/nn1289

PubMed ID: 17174898

Title: Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche.

PubMed ID: 17174898

DOI: 10.1016/j.cell.2006.10.041

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 653
Mass: 70813
Checksum: 6A2B69AA54B9A928
Sequence:

MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED 
AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD 
RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA 
TFDASRTTFT REGSFRVTTA TEQAEREEIM KQLQDAKKAE TDKTVVGPSV APGNTAPSPS 
SPTSPTPDGT ASSEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE 
LPSTMQRKTD FPIKNTVPEV EGEAESISSL CSQITSAFST PSEDPFSSAP MTKPVTLVAP 
QSPVLQANGT DSASHVLTAK PANTALAHVA MPVRETNPWA HVPDAANKEI AAIHPGTEWG 
QSSGAASPGL FQAGHRRTPS EADRWLEEVS KSVRAQQPQV SAAPLQPVLQ PPPPAAIAPP 
APPFQGHAFL TSQPVPVGVV PPLQPAFVPT QSYPVANGMP YPASNVPVVG ITPSQMVANV 
FGTAGHPQTT HPHQSPSLAK QQTFPQYETS SATTSPFFKP PAQHLNGSAA FNGVDNGGLA 
SGNRHAEVPP GTCPVDPFEA QWAALESKSK QRTNPSPTNP FSSDLQKTFE IEL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Numb

Associated with

Other Information

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. PubMed ID: 8755477

Characterization of four mammalian Numb protein isoforms: Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain. PubMed ID: 10551880

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX. PubMed ID: 9535908

Mouse numb is an essential gene involved in cortical neurogenesis. PubMed ID: 10841580

LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation. PubMed ID: 11782429

Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. PubMed ID: 12410312

Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis. PubMed ID: 15273690

Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. PubMed ID: 17174898

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079