Genular: Defining Cellular Identity and Function

Details for: Nr4a2

Gene ID: 18227

Symbol: Nr4a2

Ensembl ID: ENSMUSG00000026826

Description: nuclear receptor subfamily 4, group A, member 2

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Nuclear receptor transcription pathway
(R-MMU-383280)
Rna polymerase ii transcription
(R-MMU-73857)
Adult locomotory behavior
(GO:0008344)
Cellular response to corticotropin-releasing hormone stimulus
(GO:0071376)
Cellular response to extracellular stimulus
(GO:0031668)
Cellular response to oxidative stress
(GO:0034599)
Central nervous system neuron differentiation
(GO:0021953)
Central nervous system projection neuron axonogenesis
(GO:0021952)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-templated transcription
(GO:0006351)
Dna binding
(GO:0003677)
Dopamine biosynthetic process
(GO:0042416)
Dopamine metabolic process
(GO:0042417)
Dopaminergic neuron differentiation
(GO:0071542)
Fat cell differentiation
(GO:0045444)
Gene expression
(GO:0010467)
General adaptation syndrome
(GO:0051866)
Habenula development
(GO:0021986)
Learning or memory
(GO:0007611)
Metal ion binding
(GO:0046872)
Negative regulation of apoptotic signaling pathway
(GO:2001234)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Neuron apoptotic process
(GO:0051402)
Neuron differentiation
(GO:0030182)
Neuron maturation
(GO:0042551)
Neuron migration
(GO:0001764)
Nuclear glucocorticoid receptor binding
(GO:0035259)
Nuclear receptor activity
(GO:0004879)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of catalytic activity
(GO:0043085)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Post-embryonic development
(GO:0009791)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of dopamine metabolic process
(GO:0042053)
Regulation of gene expression
(GO:0010468)
Regulation of respiratory gaseous exchange
(GO:0043576)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to amphetamine
(GO:0001975)
Response to hypoxia
(GO:0001666)
Response to inorganic substance
(GO:0010035)
Response to insecticide
(GO:0017085)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription by rna polymerase ii
(GO:0006366)
Transcription regulator complex
(GO:0005667)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Nuclear receptor subfamily 4 group A member 2

Genular Protein ID: 4197861999

Symbol: NR4A2_MOUSE

Name: Nuclear receptor subfamily 4 group A member 2

UniProtKB Accession Codes:

Q06219 O08690

Database IDs:

Citations:

PubMed ID: 1491694

Title: Identification of a new brain-specific transcription factor, NURR1.

PubMed ID: 1491694

DOI: 10.1210/mend.6.12.1491694

PubMed ID: 9143501

Title: Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 gene.

PubMed ID: 9143501

DOI: 10.1006/geno.1997.4677

PubMed ID: 19144721

Title: Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression.

PubMed ID: 19144721

DOI: 10.1242/dev.029769

PubMed ID: 20159955

Title: The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors.

PubMed ID: 20159955

DOI: 10.1101/gad.564110

Sequence Information:

Length: 598
Mass: 66593
Checksum: D1AC5EB2FFB8D366
Sequence:

MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE ITATTSLPSF 
STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY QQHSHLPPQS EEMMPHSGSV 
YYKPSSPPTP STPSFQVQHS PMWDDPGSLH NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ 
SPPGTPVSSC QMRFDGPLHV PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA 
SQLLDTQVPS PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL 
ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK SPQDPSPPSP 
PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT QHIQQFYDLL TGSMEIIRGW 
AEKIPGFADL PKADQDLLFE SAFLELFVLR LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG 
EWIDSIVEFS SNLQNMNIDI SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT 
FNNGGLNRPN YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nr4a2

Associated with

Other Information

Identification of a new brain-specific transcription factor, NURR1. PubMed ID: 1491694

Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 gene. PubMed ID: 9143501

Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. PubMed ID: 19144721

The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. PubMed ID: 20159955

Database document:

PubMed ID: 1491694

PubMed ID: 9143501

PubMed ID: 19144721

PubMed ID: 20159955