Genular: Defining Cellular Identity and Function

Details for: Ocln

Gene ID: 18260

Symbol: Ocln

Ensembl ID: ENSMUSG00000021638

Description: occludin

Associated with

Apoptosis
(R-MMU-109581)
Apoptotic cleavage of cell adhesion proteins
(R-MMU-351906)
Apoptotic cleavage of cellular proteins
(R-MMU-111465)
Apoptotic execution phase
(R-MMU-75153)
Programmed cell death
(R-MMU-5357801)
Anchoring junction
(GO:0070161)
Apical plasma membrane
(GO:0016324)
Apicolateral plasma membrane
(GO:0016327)
Bicellular tight junction
(GO:0005923)
Bicellular tight junction assembly
(GO:0070830)
Cell-cell junction
(GO:0005911)
Cell-cell junction organization
(GO:0045216)
Cell junction
(GO:0030054)
Cell surface
(GO:0009986)
Cytoplasmic vesicle
(GO:0031410)
Endocytic vesicle
(GO:0030139)
Lateral plasma membrane
(GO:0016328)
Lysosomal membrane
(GO:0005765)
Membrane
(GO:0016020)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of protein phosphorylation
(GO:0001933)
Plasma membrane
(GO:0005886)
Positive regulation of blood-brain barrier permeability
(GO:1905605)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glucose import
(GO:0046326)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Regulation of glucose transmembrane transport
(GO:0010827)
Response to interleukin-18
(GO:0070673)
Tight junction
(GO:0070160)
Tight junction organization
(GO:0120193)

Other Information

Proteins

OCLN_MOUSE

Genular Protein ID: 2818647835

Symbol: OCLN_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q61146 Q544A7

Database IDs:

Citations:

PubMed ID: 8601611

Title: Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues.

PubMed ID: 8601611

DOI: 10.1083/jcb.133.1.43

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 10026224

Title: Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin.

PubMed ID: 10026224

DOI: 10.1074/jbc.274.9.5981

PubMed ID: 11102513

Title: Complex phenotype of mice lacking occludin, a component of tight junction strands.

PubMed ID: 11102513

DOI: 10.1091/mbc.11.12.4131

PubMed ID: 11502742

Title: Protein kinase C regulates the phosphorylation and cellular localization of occludin.

PubMed ID: 11502742

DOI: 10.1074/jbc.m104923200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23239027

Title: Analysis of the 'angulin' proteins LSR, ILDR1 and ILDR2--tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis.

PubMed ID: 23239027

DOI: 10.1242/jcs.116442

PubMed ID: 24588076

Title: Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis.

PubMed ID: 24588076

DOI: 10.1165/rcmb.2013-0353oc

Sequence Information:

Length: 521
Mass: 59000
Checksum: 21D62F370EB33E7D
Sequence:

MSVRPFESPP PYRPDEFKPN HYAPSNDMYG GEMHVRPMLS QPAYSFYPED EILHFYKWTS 
PPGVIRILSM LIIVMCIAIF ACVASTLAWD RGYGTGLFGG SLNYPYSGFG YGGGYGGGYG 
GYGYGYGGYT DPRAAKGFLL AMAAFCFIAS LVIFVTSVIR SGMSRTRRYY LIVIIVSAIL 
GIMVFIATIV YIMGVNPTAQ ASGSMYGSQI YMICNQFYTP GGTGLYVDQY LYHYCVVDPQ 
EAIAIVLGFM IIVAFALIIF FAVKTRRKMD RYDKSNILWD KEHIYDEQPP NVEEWVKNVS 
AGTQDMPPPP SDYAERVDSP MAYSSNGKVN GKRSYPESFY KSTPLVPEVA QEIPLTLSVD 
DFRQPRYSSN GNLETPSKRA PTKGKAGKGK RTDPDHYETD YTTGGESCEE LEEDWVREYP 
PITSDQQRQL YKRNFDAGLQ EYKSLQAELD DVNKELSRLD KELDDYREES EEYMAAADEY 
NRLKQVKGSA DYKSKRNYCK QLKSKLSHIK RMVGDYDRRK P

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ocln

Associated with

Other Information

Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. PubMed ID: 8601611

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin. PubMed ID: 10026224

Complex phenotype of mice lacking occludin, a component of tight junction strands. PubMed ID: 11102513

Protein kinase C regulates the phosphorylation and cellular localization of occludin. PubMed ID: 11502742

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Analysis of the 'angulin' proteins LSR, ILDR1 and ILDR2--tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis. PubMed ID: 23239027

Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. PubMed ID: 24588076