Genular: Defining Cellular Identity and Function

Details for: Ogg1

Gene ID: 18294

Symbol: Ogg1

Ensembl ID: ENSMUSG00000030271

Description: 8-oxoguanine DNA-glycosylase 1

Associated with

Apex1-independent resolution of ap sites via the single nucleotide replacement pathway
(R-MMU-5649702)
Base excision repair
(R-MMU-73884)
Cleavage of the damaged purine
(R-MMU-110331)
Cleavage of the damaged pyrimidine
(R-MMU-110329)
Depurination
(R-MMU-73927)
Depyrimidination
(R-MMU-73928)
Displacement of dna glycosylase by apex1
(R-MMU-110357)
Recognition and association of dna glycosylase with site containing an affected purine
(R-MMU-110330)
Resolution of abasic sites (ap sites)
(R-MMU-73933)
8-oxo-7,8-dihydroguanine dna n-glycosylase activity
(GO:0034039)
Base-excision repair
(GO:0006284)
Base-excision repair, ap site formation
(GO:0006285)
Catalytic activity
(GO:0003824)
Class i dna-(apurinic or apyrimidinic site) endonuclease activity
(GO:0140078)
Damaged dna binding
(GO:0003684)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna n-glycosylase activity
(GO:0019104)
Dna repair
(GO:0006281)
Hydrolase activity
(GO:0016787)
Hydrolase activity, acting on glycosyl bonds
(GO:0016798)
Lyase activity
(GO:0016829)
Metabolic process
(GO:0008152)
Microtubule binding
(GO:0008017)
Mitochondrion
(GO:0005739)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of double-strand break repair via single-strand annealing
(GO:1901291)
Nuclear matrix
(GO:0016363)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleotide-excision repair
(GO:0006289)
Nucleus
(GO:0005634)
Oxidized base lesion dna n-glycosylase activity
(GO:0000702)
Oxidized purine dna binding
(GO:0032357)
Oxidized purine nucleobase lesion dna n-glycosylase activity
(GO:0008534)
Protein-containing complex
(GO:0032991)
Regulation of dna-templated transcription
(GO:0006355)
Response to estradiol
(GO:0032355)
Response to oxidative stress
(GO:0006979)
Response to radiation
(GO:0009314)

Other Information

Proteins

N-glycosylase/DNA lyase

Genular Protein ID: 1005369624

Symbol: OGG1_MOUSE

Name: N-glycosylase/DNA lyase

UniProtKB Accession Codes:

O08760 O08733 O08910 O08991 O35617 O35915 Q9QXE8

Database IDs:

Citations:

PubMed ID: 9187114

Title: Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue.

PubMed ID: 9187114

PubMed ID: 9197244

Title: A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer.

PubMed ID: 9197244

DOI: 10.1016/s0960-9822(06)00187-4

PubMed ID: 9321410

Title: Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites.

PubMed ID: 9321410

DOI: 10.1093/emboj/16.20.6314

PubMed ID: 9207108

Title: Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase.

PubMed ID: 9207108

DOI: 10.1073/pnas.94.14.7429

PubMed ID: 9434942

Title: Genomic structure and chromosomal localization of the mouse Ogg1 gene that is involved in the repair of 8-hydroxyguanine in DNA damage.

PubMed ID: 9434942

DOI: 10.1007/s003359900675

Sequence Information:

Length: 345
Mass: 38883
Checksum: 75BB0DDB084E4947
Sequence:

MLFRSWLPSS MRHRTLSSSP ALWASIPCPR SELRLDLVLA SGQSFRWKEQ SPAHWSGVLA 
DQVWTLTQTE DQLYCTVYRG DDSQVSRPTL EELETLHKYF QLDVSLAQLY SHWASVDSHF 
QRVAQKFQGV RLLRQDPTEC LFSFICSSNN NIARITGMVE RLCQAFGPRL IQLDDVTYHG 
FPNLHALAGP EAETHLRKLG LGYRARYVRA SAKAILEEQG GPAWLQQLRV APYEEAHKAL 
CTLPGVGAKV ADCICLMALD KPQAVPVDVH VWQIAHRDYG WHPKTSQAKG PSPLANKELG 
NFFRNLWGPY AGWAQAVLFS ADLRQPSLSR EPPAKRKKGS KRPEG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ogg1

Associated with

Other Information

Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. PubMed ID: 9187114

A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer. PubMed ID: 9197244

Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites. PubMed ID: 9321410