Details for: AGT

Gene ID: 183

Symbol: AGT

Ensembl ID: ENSG00000135744

Description: angiotensinogen

Associated with

  • Class a/1 (rhodopsin-like receptors)
    (R-HSA-373076)
  • G alpha (i) signalling events
    (R-HSA-418594)
  • G alpha (q) signalling events
    (R-HSA-416476)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Gpcr ligand binding
    (R-HSA-500792)
  • Metabolism
    (R-HSA-1430728)
  • Metabolism of angiotensinogen to angiotensins
    (R-HSA-2022377)
  • Metabolism of lipids
    (R-HSA-556833)
  • Metabolism of proteins
    (R-HSA-392499)
  • Peptide hormone metabolism
    (R-HSA-2980736)
  • Peptide ligand-binding receptors
    (R-HSA-375276)
  • Ppara activates gene expression
    (R-HSA-1989781)
  • Regulation of lipid metabolism by pparalpha
    (R-HSA-400206)
  • Signaling by gpcr
    (R-HSA-372790)
  • Signal transduction
    (R-HSA-162582)
  • Angiotensin-activated signaling pathway
    (GO:0038166)
  • Blood microparticle
    (GO:0072562)
  • Blood vessel remodeling
    (GO:0001974)
  • Cell-cell signaling
    (GO:0007267)
  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Extracellular exosome
    (GO:0070062)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • G protein-coupled receptor signaling pathway coupled to cgmp nucleotide second messenger
    (GO:0007199)
  • Growth factor activity
    (GO:0008083)
  • Hormone activity
    (GO:0005179)
  • Kidney development
    (GO:0001822)
  • Low-density lipoprotein particle remodeling
    (GO:0034374)
  • Maintenance of blood vessel diameter homeostasis by renin-angiotensin
    (GO:0002034)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of map kinase activity
    (GO:0043407)
  • Negative regulation of neurotrophin trk receptor signaling pathway
    (GO:0051387)
  • Negative regulation of sodium ion transmembrane transport
    (GO:1902306)
  • Nitric oxide-cgmp-mediated signaling
    (GO:0038060)
  • Phospholipase c-activating g protein-coupled receptor signaling pathway
    (GO:0007200)
  • Positive regulation of branching involved in ureteric bud morphogenesis
    (GO:0090190)
  • Positive regulation of cardiac muscle hypertrophy
    (GO:0010613)
  • Positive regulation of coa-transferase activity
    (GO:1905920)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of endothelial cell migration
    (GO:0010595)
  • Positive regulation of epidermal growth factor receptor signaling pathway
    (GO:0045742)
  • Positive regulation of epithelial to mesenchymal transition
    (GO:0010718)
  • Positive regulation of extracellular matrix assembly
    (GO:1901203)
  • Positive regulation of extrinsic apoptotic signaling pathway
    (GO:2001238)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of gap junction assembly
    (GO:1903598)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of macrophage derived foam cell differentiation
    (GO:0010744)
  • Positive regulation of membrane hyperpolarization
    (GO:1902632)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of nf-kappab transcription factor activity
    (GO:0051092)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein metabolic process
    (GO:0051247)
  • Positive regulation of reactive oxygen species metabolic process
    (GO:2000379)
  • Positive regulation of superoxide anion generation
    (GO:0032930)
  • Protein binding
    (GO:0005515)
  • Receptor ligand activity
    (GO:0048018)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of blood pressure
    (GO:0008217)
  • Regulation of blood volume by renin-angiotensin
    (GO:0002016)
  • Regulation of cardiac conduction
    (GO:1903779)
  • Regulation of cell growth
    (GO:0001558)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of extracellular matrix assembly
    (GO:1901201)
  • Regulation of renal output by angiotensin
    (GO:0002019)
  • Regulation of renal sodium excretion
    (GO:0035813)
  • Regulation of vasoconstriction
    (GO:0019229)
  • Renal system process
    (GO:0003014)
  • Renin-angiotensin regulation of aldosterone production
    (GO:0002018)
  • Response to angiotensin
    (GO:1990776)
  • Response to muscle activity involved in regulation of muscle adaptation
    (GO:0014873)
  • Serine-type endopeptidase inhibitor activity
    (GO:0004867)
  • Sodium channel regulator activity
    (GO:0017080)
  • Superoxide-generating nadph oxidase activator activity
    (GO:0016176)
  • Type 1 angiotensin receptor binding
    (GO:0031702)
  • Type 2 angiotensin receptor binding
    (GO:0031703)
  • Vasoconstriction
    (GO:0042310)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.9107
    Cell Significance Index: -16.0100
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 28.8273
    Cell Significance Index: 76.0500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 6.4668
    Cell Significance Index: 54.3200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 6.3644
    Cell Significance Index: 23.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3056
    Cell Significance Index: -16.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.7291
    Cell Significance Index: 740.0600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.6518
    Cell Significance Index: 44.6700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 2.1561
    Cell Significance Index: 30.1500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.8528
    Cell Significance Index: 10.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8384
    Cell Significance Index: 58.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.7932
    Cell Significance Index: 113.0200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.6003
    Cell Significance Index: 23.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4983
    Cell Significance Index: 5.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4935
    Cell Significance Index: 22.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4493
    Cell Significance Index: 85.5100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4214
    Cell Significance Index: 6.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2443
    Cell Significance Index: 24.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2310
    Cell Significance Index: 208.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1336
    Cell Significance Index: 21.7300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.1084
    Cell Significance Index: 1.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1070
    Cell Significance Index: 5.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0974
    Cell Significance Index: 1.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0800
    Cell Significance Index: 9.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0569
    Cell Significance Index: 6.1900
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.0522
    Cell Significance Index: 0.5800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0415
    Cell Significance Index: 0.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0286
    Cell Significance Index: 4.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0139
    Cell Significance Index: 0.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0019
    Cell Significance Index: 0.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0003
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0081
    Cell Significance Index: -5.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0088
    Cell Significance Index: -16.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0094
    Cell Significance Index: -0.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0108
    Cell Significance Index: -0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0130
    Cell Significance Index: -7.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0171
    Cell Significance Index: -26.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0197
    Cell Significance Index: -26.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0220
    Cell Significance Index: -1.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0225
    Cell Significance Index: -17.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0238
    Cell Significance Index: -17.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0271
    Cell Significance Index: -5.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0279
    Cell Significance Index: -17.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0312
    Cell Significance Index: -17.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0321
    Cell Significance Index: -2.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0337
    Cell Significance Index: -3.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0444
    Cell Significance Index: -20.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0479
    Cell Significance Index: -13.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0489
    Cell Significance Index: -1.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0542
    Cell Significance Index: -6.9500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0582
    Cell Significance Index: -0.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0611
    Cell Significance Index: -6.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0621
    Cell Significance Index: -3.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0700
    Cell Significance Index: -2.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0710
    Cell Significance Index: -14.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0869
    Cell Significance Index: -15.6600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0924
    Cell Significance Index: -1.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1013
    Cell Significance Index: -13.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1107
    Cell Significance Index: -12.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1115
    Cell Significance Index: -5.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1215
    Cell Significance Index: -2.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1217
    Cell Significance Index: -17.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1248
    Cell Significance Index: -16.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1281
    Cell Significance Index: -15.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1541
    Cell Significance Index: -11.8300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1605
    Cell Significance Index: -2.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1634
    Cell Significance Index: -3.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1707
    Cell Significance Index: -17.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1904
    Cell Significance Index: -4.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1909
    Cell Significance Index: -14.2300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2132
    Cell Significance Index: -2.4400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2145
    Cell Significance Index: -1.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2174
    Cell Significance Index: -17.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2240
    Cell Significance Index: -15.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2679
    Cell Significance Index: -13.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2747
    Cell Significance Index: -7.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2972
    Cell Significance Index: -7.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3102
    Cell Significance Index: -16.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3255
    Cell Significance Index: -18.2700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3359
    Cell Significance Index: -14.6000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3465
    Cell Significance Index: -4.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3485
    Cell Significance Index: -16.3800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.3540
    Cell Significance Index: -3.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3652
    Cell Significance Index: -18.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3852
    Cell Significance Index: -17.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4238
    Cell Significance Index: -8.8700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4412
    Cell Significance Index: -7.0000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4497
    Cell Significance Index: -7.4100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4504
    Cell Significance Index: -10.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4598
    Cell Significance Index: -17.4100
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.4695
    Cell Significance Index: -5.7200
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.4815
    Cell Significance Index: -4.7500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.5024
    Cell Significance Index: -7.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5073
    Cell Significance Index: -17.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5206
    Cell Significance Index: -18.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5375
    Cell Significance Index: -15.3400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5436
    Cell Significance Index: -7.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5459
    Cell Significance Index: -20.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5461
    Cell Significance Index: -17.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5463
    Cell Significance Index: -15.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5605
    Cell Significance Index: -17.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: AGT is a 604-amino acid protein that is secreted from the liver and circulates in the bloodstream. 2. **Function**: AGT is converted into angiotensin I by renin, which is then converted into angiotensin II, a potent vasoconstrictor and stimulator of aldosterone release. 3. **Expression**: AGT is expressed in various tissues, including the liver, kidneys, and blood vessels. 4. **Signaling pathways**: AGT is involved in multiple signaling pathways, including the angiotensin-activated signaling pathway, G protein-coupled receptor signaling pathway, and phospholipase C-activating G protein-coupled receptor signaling pathway. **Pathways and Functions** The AGT gene is involved in various signaling pathways, including: 1. **Angiotensin-activated signaling pathway**: AGT is converted into angiotensin I by renin, which is then converted into angiotensin II, a potent vasoconstrictor that stimulates the release of aldosterone. 2. **G protein-coupled receptor signaling pathway**: AGT is involved in the signaling pathway of G protein-coupled receptors, including the type 1 and type 2 angiotensin receptors. 3. **Phospholipase C-activating G protein-coupled receptor signaling pathway**: AGT is involved in the signaling pathway of phospholipase C-activating G protein-coupled receptors, which play a role in vasoconstriction and blood pressure regulation. 4. **Metabolism**: AGT is involved in the metabolism of lipids, proteins, and other molecules, including the regulation of lipid metabolism by PPARα. **Clinical Significance** Dysregulation of the AGT gene has been implicated in various cardiovascular and renal disorders, including: 1. **Hypertension**: Overexpression of AGT has been linked to hypertension, a major risk factor for cardiovascular disease. 2. **Renal disease**: Dysregulation of the AGT gene has been implicated in various renal diseases, including kidney disease and kidney failure. 3. **Cardiovascular disease**: AGT has been linked to various cardiovascular diseases, including heart failure, coronary artery disease, and stroke. 4. **Diabetes**: AGT has been implicated in the development of type 2 diabetes, a metabolic disorder characterized by insulin resistance and hyperglycemia. In conclusion, the AGT gene plays a critical role in regulating blood pressure and fluid balance in the body, and dysregulation of this gene has been implicated in various cardiovascular and renal disorders. Further research is needed to fully understand the mechanisms by which AGT regulates blood pressure and fluid balance, and to develop effective therapeutic strategies for the treatment of AGT-related disorders.

Genular Protein ID: 2412208657

Symbol: ANGT_HUMAN

Name: Serpin A8

UniProtKB Accession Codes:

P01019 Q16358 Q16359 Q96F91

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 13 Ensembl 5 EvolutionaryTrace 1 GO 58 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 MANE-Select 1 MEROPS 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 20 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6089875

Title: Primary structure of human preangiotensinogen deduced from the cloned cDNA sequence.

PubMed ID: 6089875

DOI: 10.1021/bi00311a006

PubMed ID: 2924688

Title: Structure of human angiotensinogen gene.

PubMed ID: 2924688

DOI: 10.1089/dna.1.1989.8.87

PubMed ID: 1692023

Title: Structure and expression of the human angiotensinogen gene. Identification of a unique and highly active promoter.

PubMed ID: 1692023

DOI: 10.1016/s0021-9258(19)39153-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2885106

Title: Molecular cloning of human angiotensinogen cDNA and evidence for the presence of its mRNA in rat heart.

PubMed ID: 2885106

DOI: 10.1161/01.res.60.5.786

PubMed ID: 3579322

Title: Tissue specific hormonal regulation of the rat angiotensinogen gene expression.

PubMed ID: 3579322

DOI: 10.1016/0003-9861(87)90148-2

PubMed ID: 7607642

Title: Detection and characterization of new mutations in the human angiotensinogen gene (AGT).

PubMed ID: 7607642

DOI: 10.1007/bf00214197

PubMed ID: 7259779

Title: The amino terminal amino acid sequence of human angiotensinogen.

PubMed ID: 7259779

DOI: 10.1016/0006-291x(81)90762-2

PubMed ID: 7539791

Title: Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma.

PubMed ID: 7539791

DOI: 10.1074/jbc.270.23.13645

PubMed ID: 4300938

Title: Enzymatic degradation and electrophoresis of human angiotensin I.

PubMed ID: 4300938

DOI: 10.1016/0005-2795(68)90239-0

PubMed ID: 4322742

Title: A dipeptidyl carboxypeptidase that converts angiotensin I and inactivates bradykinin.

PubMed ID: 4322742

DOI: 10.1016/0005-2795(70)90017-6

PubMed ID: 3934016

Title: Processing of rat and human angiotensinogen precursors by microsomal membranes.

PubMed ID: 3934016

DOI: 10.1016/0303-7207(85)90039-5

PubMed ID: 1132082

Title: Angiotensin III: (DES-Aspartic Acid-1)-Angiotensin II. Evidence and speculation for its role as an important agonist in the renin - angiotensin system.

PubMed ID: 1132082

DOI: 10.1161/01.res.36.6.38

PubMed ID: 1567413

Title: Cloning and characterization of a human angiotensin II type 1 receptor.

PubMed ID: 1567413

DOI: 10.1016/s0006-291x(05)80288-8

PubMed ID: 8185599

Title: Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor.

PubMed ID: 8185599

DOI: 10.1006/bbrc.1994.1613

PubMed ID: 10619573

Title: The renin-angiotensin-aldosterone system: a specific target for hypertension management.

PubMed ID: 10619573

DOI: 10.1016/s0895-7061(99)00103-x

PubMed ID: 10969042

Title: A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.

PubMed ID: 10969042

DOI: 10.1161/01.res.87.5.e1

PubMed ID: 11815627

Title: Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.

PubMed ID: 11815627

DOI: 10.1074/jbc.m200581200

PubMed ID: 12045255

Title: Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.

PubMed ID: 12045255

DOI: 10.1172/jci14276

PubMed ID: 15283675

Title: Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism.

PubMed ID: 15283675

DOI: 10.1042/bj20040634

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17138938

Title: Mass-spectrometric identification of a novel angiotensin peptide in human plasma.

PubMed ID: 17138938

DOI: 10.1161/01.atv.0000253889.09765.5f

PubMed ID: 18793332

Title: Renin-angiotensin system revisited.

PubMed ID: 18793332

DOI: 10.1111/j.1365-2796.2008.01981.x

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9492317

Title: The octapeptide angiotensin II adopts a well-defined structure in a phospholipid environment.

PubMed ID: 9492317

DOI: 10.1046/j.1432-1327.1998.2510448.x

PubMed ID: 12752436

Title: Comparison of the solution structures of angiotensin I & II. Implication for structure-function relationship.

PubMed ID: 12752436

DOI: 10.1046/j.1432-1033.2003.03573.x

PubMed ID: 20927107

Title: A redox switch in angiotensinogen modulates angiotensin release.

PubMed ID: 20927107

DOI: 10.1038/nature09505

PubMed ID: 1394429

Title: Molecular basis of human hypertension: role of angiotensinogen.

PubMed ID: 1394429

DOI: 10.1016/0092-8674(92)90275-h

PubMed ID: 8513325

Title: A molecular variant of angiotensinogen associated with preeclampsia.

PubMed ID: 8513325

DOI: 10.1038/ng0593-59

PubMed ID: 7744780

Title: A mutation of angiotensinogen in a patient with preeclampsia leads to altered kinetics of the renin-angiotensin system.

PubMed ID: 7744780

DOI: 10.1074/jbc.270.19.11430

PubMed ID: 8621667

Title: The natural mutation Y248C of human angiotensinogen leads to abnormal glycosylation and altered immunological recognition of the protein.

PubMed ID: 8621667

DOI: 10.1074/jbc.271.16.9838

PubMed ID: 16116425

Title: Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.

PubMed ID: 16116425

DOI: 10.1038/ng1623

Sequence Information:

  • Length: 476
  • Mass: 52070
  • Checksum: EF44870358ABAD90
  • Sequence:
    • MAPAGVSLRA TILCLLAWAG LAAGDRVYIH PFHLVIHNES TCEQLAKANA GKPKDPTFIP 
APIQAKTSPV DEKALQDQLV LVAAKLDTED KLRAAMVGML ANFLGFRIYG MHSELWGVVH 
GATVLSPTAV FGTLASLYLG ALDHTADRLQ AILGVPWKDK NCTSRLDAHK VLSALQAVQG 
LLVAQGRADS QAQLLLSTVV GVFTAPGLHL KQPFVQGLAL YTPVVLPRSL DFTELDVAAE 
KIDRFMQAVT GWKTGCSLMG ASVDSTLAFN TYVHFQGKMK GFSLLAEPQE FWVDNSTSVS 
VPMLSGMGTF QHWSDIQDNF SVTQVPFTES ACLLLIQPHY ASDLDKVEGL TFQQNSLNWM 
KKLSPRTIHL TMPQLVLQGS YDLQDLLAQA ELPAILHTEL NLQKLSNDRI RVGEVLNSIF 
FELEADEREP TESTQQLNKP EVLEVTLNRP FLFAVYDQSA TALHFLGRVA NPLSTA

Genular Protein ID: 1792447071

Symbol: B0ZBE2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0ZBE2 A0A024R3V3

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 GO 4 Gene3D 2 HOGENOM 1 InterPro 8 MEROPS 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 485
  • Mass: 53154
  • Checksum: 5026C2DFB2DD236E
  • Sequence:
    • MRKRAPQSEM APAGVSLRAT ILCLLAWAGL AAGDRVYIHP FHLVIHNEST CEQLAKANAG 
KPKDPTFIPA PIQAKTSPVD EKALQDQLVL VAAKLDTEDK LRAAMVGMLA NFLGFRIYGM 
HSELWGVVHG ATVLSPTAVF GTLASLYLGA LDHTADRLQA ILGVPWKDKN CTSRLDAHKV 
LSALQAVQGL LVAQGRADSQ AQLLLSTVVG VFTAPGLHLK QPFVQGLALY TPVVLPRSLD 
FTELDVAAEK IDRFMQAVTG WKTGCSLMGA SVDSTLAFNT YVHFQGKMKG FSLLAEPQEF 
WVDNSTSVSV PMLSGMGTFQ HWSDIQDNFS VTQVPFTESA CLLLIQPHYA SDLDKVEGLT 
FQQNSLNWMK KLSPRTIHLT MPQLVLQGSY DLQDLLAQAE LPAILHTELN LQKLSNDRIR 
VGEVLNSIFF ELEADEREPT ESTQQLNKPE VLEVTLNRPF LFAVYDQSAT ALHFLGRVAN 
PLSTA

Genular Protein ID: 1839707944

Symbol: B2R5S1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R5S1

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 8 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 485
  • Mass: 53212
  • Checksum: D2AD5269F0B9B260
  • Sequence:
    • MRKRAPQSEM APAGVSLRAT ILCLLAWAGL AAGDRVYIHP FHLVIHNEST CEQLAKANAG 
KPKDPTFIPA PIQAKTSPVD EKALQDQLVL VAAKLDTEDK LRAAMVGMLA NFLGFRIYGM 
HSELWGVVHG ATVLSPTAVF GTLASLYLGA LDHTADRLQA ILGVPWKDKN CTSRLDAHKV 
LSALQAVQGL LVAQDRADSQ AQLLLSTVVG VFTAPGLHLK QPFVQGLALY TPVVLPRSLD 
FTELDVAAEK IDRFMQAVTG WKTGCSLMGA SVDSTLAFNT YVHFQGKMKG FSLLAEPQEF 
WVDNSTSVSV PMLSGMGTFQ HWSDIQDNFS VTQVPFTESA CLLLIQPHYA SDLDKVEGLT 
FQQNSLNWMK KLSPRTIHLT MPQLVLQGSY DLQDLLAQAE LPAILHTELN LQKLSNDRIR 
VGEVLNSIFF ELEADEREPT ESTQQLNKPE VLEVTLNRPF LFAVYDQSAT ALHFLGRVAN 
PLSTA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.