Details for: AGT

Gene ID: 183

Symbol: AGT

Ensembl ID: ENSG00000135744

Description: angiotensinogen

Associated with

  • Class a/1 (rhodopsin-like receptors)
    (R-HSA-373076)
  • G alpha (i) signalling events
    (R-HSA-418594)
  • G alpha (q) signalling events
    (R-HSA-416476)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Gpcr ligand binding
    (R-HSA-500792)
  • Metabolism
    (R-HSA-1430728)
  • Metabolism of angiotensinogen to angiotensins
    (R-HSA-2022377)
  • Metabolism of lipids
    (R-HSA-556833)
  • Metabolism of proteins
    (R-HSA-392499)
  • Peptide hormone metabolism
    (R-HSA-2980736)
  • Peptide ligand-binding receptors
    (R-HSA-375276)
  • Ppara activates gene expression
    (R-HSA-1989781)
  • Regulation of lipid metabolism by pparalpha
    (R-HSA-400206)
  • Signaling by gpcr
    (R-HSA-372790)
  • Signal transduction
    (R-HSA-162582)
  • Angiotensin-activated signaling pathway
    (GO:0038166)
  • Blood microparticle
    (GO:0072562)
  • Blood vessel remodeling
    (GO:0001974)
  • Cell-cell signaling
    (GO:0007267)
  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Cytosol
    (GO:0005829)
  • Extracellular exosome
    (GO:0070062)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • G protein-coupled receptor signaling pathway coupled to cgmp nucleotide second messenger
    (GO:0007199)
  • Growth factor activity
    (GO:0008083)
  • Hormone activity
    (GO:0005179)
  • Kidney development
    (GO:0001822)
  • Low-density lipoprotein particle remodeling
    (GO:0034374)
  • Maintenance of blood vessel diameter homeostasis by renin-angiotensin
    (GO:0002034)
  • Negative regulation of map kinase activity
    (GO:0043407)
  • Negative regulation of neurotrophin trk receptor signaling pathway
    (GO:0051387)
  • Nitric oxide mediated signal transduction
    (GO:0007263)
  • Phospholipase c-activating g protein-coupled receptor signaling pathway
    (GO:0007200)
  • Positive regulation of activation of janus kinase activity
    (GO:0010536)
  • Positive regulation of branching involved in ureteric bud morphogenesis
    (GO:0090190)
  • Positive regulation of cardiac muscle hypertrophy
    (GO:0010613)
  • Positive regulation of coa-transferase activity
    (GO:1905920)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of endothelial cell migration
    (GO:0010595)
  • Positive regulation of epidermal growth factor receptor signaling pathway
    (GO:0045742)
  • Positive regulation of epithelial to mesenchymal transition
    (GO:0010718)
  • Positive regulation of extracellular matrix assembly
    (GO:1901203)
  • Positive regulation of extrinsic apoptotic signaling pathway
    (GO:2001238)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of gap junction assembly
    (GO:1903598)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of macrophage derived foam cell differentiation
    (GO:0010744)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of nad(p)h oxidase activity
    (GO:0033864)
  • Positive regulation of nf-kappab transcription factor activity
    (GO:0051092)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein metabolic process
    (GO:0051247)
  • Positive regulation of protein tyrosine kinase activity
    (GO:0061098)
  • Positive regulation of reactive oxygen species metabolic process
    (GO:2000379)
  • Positive regulation of transforming growth factor beta1 activation
    (GO:1901394)
  • Protein binding
    (GO:0005515)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of blood pressure
    (GO:0008217)
  • Regulation of blood volume by renin-angiotensin
    (GO:0002016)
  • Regulation of cardiac conduction
    (GO:1903779)
  • Regulation of cell growth
    (GO:0001558)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of extracellular matrix assembly
    (GO:1901201)
  • Regulation of renal output by angiotensin
    (GO:0002019)
  • Regulation of renal sodium excretion
    (GO:0035813)
  • Regulation of vasoconstriction
    (GO:0019229)
  • Renal system process
    (GO:0003014)
  • Renin-angiotensin regulation of aldosterone production
    (GO:0002018)
  • Response to angiotensin
    (GO:1990776)
  • Response to muscle activity involved in regulation of muscle adaptation
    (GO:0014873)
  • Serine-type endopeptidase inhibitor activity
    (GO:0004867)
  • Type 1 angiotensin receptor binding
    (GO:0031702)
  • Type 2 angiotensin receptor binding
    (GO:0031703)
  • Vasoconstriction
    (GO:0042310)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 6.67
    Marker Score: 21,858
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 4.34
    Marker Score: 6,690
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.36
    Marker Score: 12,695
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.99
    Marker Score: 1,982
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.87
    Marker Score: 40,014
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.87
    Marker Score: 1,233
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.79
    Marker Score: 7,736
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.58
    Marker Score: 10,175
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.54
    Marker Score: 1,334
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169,008
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.36
    Marker Score: 513
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 1.25
    Marker Score: 387
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.21
    Marker Score: 1,292
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,802
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.11
    Marker Score: 1,172
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.11
    Marker Score: 599
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.05
    Marker Score: 714
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,789
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.03
    Marker Score: 2,433
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.01
    Marker Score: 15,749
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1
    Marker Score: 624
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,809
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,033
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.98
    Marker Score: 1,357
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,321
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.89
    Marker Score: 266
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.83
    Marker Score: 828
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.81
    Marker Score: 1,319
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.8
    Marker Score: 787
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 601
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.78
    Marker Score: 371
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 695
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.73
    Marker Score: 2,086
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.72
    Marker Score: 197
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 456
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.68
    Marker Score: 1,288
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.66
    Marker Score: 3,979
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.65
    Marker Score: 2,304
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.61
    Marker Score: 179
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 390
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.56
    Marker Score: 257
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.55
    Marker Score: 145
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.52
    Marker Score: 193
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.51
    Marker Score: 526
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.51
    Marker Score: 210
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.51
    Marker Score: 431
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.5
    Marker Score: 126
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.48
    Marker Score: 1,779
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.47
    Marker Score: 540
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.45
    Marker Score: 444
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 268
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.44
    Marker Score: 97
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.43
    Marker Score: 415
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.42
    Marker Score: 398
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.41
    Marker Score: 189
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4
    Marker Score: 489
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.4
    Marker Score: 303
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.4
    Marker Score: 106
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.39
    Marker Score: 207
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.38
    Marker Score: 223
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.38
    Marker Score: 1,200
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.38
    Marker Score: 140
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.38
    Marker Score: 1,452
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.37
    Marker Score: 151
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.37
    Marker Score: 266
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 367
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.36
    Marker Score: 239
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 155
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.35
    Marker Score: 91
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.34
    Marker Score: 233
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.34
    Marker Score: 140
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.34
    Marker Score: 714
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.34
    Marker Score: 555
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.33
    Marker Score: 216
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.32
    Marker Score: 91
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.31
    Marker Score: 4,217
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.31
    Marker Score: 131
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.3
    Marker Score: 484
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3
    Marker Score: 124
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.28
    Marker Score: 177
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.27
    Marker Score: 113
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.27
    Marker Score: 123
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.27
    Marker Score: 58
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.27
    Marker Score: 93
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 157
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.26
    Marker Score: 451
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.26
    Marker Score: 144
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.26
    Marker Score: 73

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: AGT is a 604-amino acid protein that is secreted from the liver and circulates in the bloodstream. 2. **Function**: AGT is converted into angiotensin I by renin, which is then converted into angiotensin II, a potent vasoconstrictor and stimulator of aldosterone release. 3. **Expression**: AGT is expressed in various tissues, including the liver, kidneys, and blood vessels. 4. **Signaling pathways**: AGT is involved in multiple signaling pathways, including the angiotensin-activated signaling pathway, G protein-coupled receptor signaling pathway, and phospholipase C-activating G protein-coupled receptor signaling pathway. **Pathways and Functions** The AGT gene is involved in various signaling pathways, including: 1. **Angiotensin-activated signaling pathway**: AGT is converted into angiotensin I by renin, which is then converted into angiotensin II, a potent vasoconstrictor that stimulates the release of aldosterone. 2. **G protein-coupled receptor signaling pathway**: AGT is involved in the signaling pathway of G protein-coupled receptors, including the type 1 and type 2 angiotensin receptors. 3. **Phospholipase C-activating G protein-coupled receptor signaling pathway**: AGT is involved in the signaling pathway of phospholipase C-activating G protein-coupled receptors, which play a role in vasoconstriction and blood pressure regulation. 4. **Metabolism**: AGT is involved in the metabolism of lipids, proteins, and other molecules, including the regulation of lipid metabolism by PPARα. **Clinical Significance** Dysregulation of the AGT gene has been implicated in various cardiovascular and renal disorders, including: 1. **Hypertension**: Overexpression of AGT has been linked to hypertension, a major risk factor for cardiovascular disease. 2. **Renal disease**: Dysregulation of the AGT gene has been implicated in various renal diseases, including kidney disease and kidney failure. 3. **Cardiovascular disease**: AGT has been linked to various cardiovascular diseases, including heart failure, coronary artery disease, and stroke. 4. **Diabetes**: AGT has been implicated in the development of type 2 diabetes, a metabolic disorder characterized by insulin resistance and hyperglycemia. In conclusion, the AGT gene plays a critical role in regulating blood pressure and fluid balance in the body, and dysregulation of this gene has been implicated in various cardiovascular and renal disorders. Further research is needed to fully understand the mechanisms by which AGT regulates blood pressure and fluid balance, and to develop effective therapeutic strategies for the treatment of AGT-related disorders.

Genular Protein ID: 2412208657

Symbol: ANGT_HUMAN

Name: Serpin A8

UniProtKB Accession Codes:

P01019 Q16358 Q16359 Q96F91

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 13 EPD 1 Ensembl 5 EvolutionaryTrace 1 GO 61 Gene3D 2 GeneCards 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 MANE-Select 1 MEROPS 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 29 PDBsum 20 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6089875

Title: Primary structure of human preangiotensinogen deduced from the cloned cDNA sequence.

PubMed ID: 6089875

DOI: 10.1021/bi00311a006

PubMed ID: 2924688

Title: Structure of human angiotensinogen gene.

PubMed ID: 2924688

DOI: 10.1089/dna.1.1989.8.87

PubMed ID: 1692023

Title: Structure and expression of the human angiotensinogen gene. Identification of a unique and highly active promoter.

PubMed ID: 1692023

DOI: 10.1016/s0021-9258(19)39153-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2885106

Title: Molecular cloning of human angiotensinogen cDNA and evidence for the presence of its mRNA in rat heart.

PubMed ID: 2885106

DOI: 10.1161/01.res.60.5.786

PubMed ID: 3579322

Title: Tissue specific hormonal regulation of the rat angiotensinogen gene expression.

PubMed ID: 3579322

DOI: 10.1016/0003-9861(87)90148-2

PubMed ID: 7607642

Title: Detection and characterization of new mutations in the human angiotensinogen gene (AGT).

PubMed ID: 7607642

DOI: 10.1007/bf00214197

PubMed ID: 7259779

Title: The amino terminal amino acid sequence of human angiotensinogen.

PubMed ID: 7259779

DOI: 10.1016/0006-291x(81)90762-2

PubMed ID: 7539791

Title: Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma.

PubMed ID: 7539791

DOI: 10.1074/jbc.270.23.13645

PubMed ID: 4300938

Title: Enzymatic degradation and electrophoresis of human angiotensin I.

PubMed ID: 4300938

DOI: 10.1016/0005-2795(68)90239-0

PubMed ID: 4322742

Title: A dipeptidyl carboxypeptidase that converts angiotensin I and inactivates bradykinin.

PubMed ID: 4322742

DOI: 10.1016/0005-2795(70)90017-6

PubMed ID: 3934016

Title: Processing of rat and human angiotensinogen precursors by microsomal membranes.

PubMed ID: 3934016

DOI: 10.1016/0303-7207(85)90039-5

PubMed ID: 1132082

Title: Angiotensin III: (DES-Aspartic Acid-1)-Angiotensin II. Evidence and speculation for its role as an important agonist in the renin - angiotensin system.

PubMed ID: 1132082

DOI: 10.1161/01.res.36.6.38

PubMed ID: 1567413

Title: Cloning and characterization of a human angiotensin II type 1 receptor.

PubMed ID: 1567413

DOI: 10.1016/s0006-291x(05)80288-8

PubMed ID: 8185599

Title: Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor.

PubMed ID: 8185599

DOI: 10.1006/bbrc.1994.1613

PubMed ID: 10619573

Title: The renin-angiotensin-aldosterone system: a specific target for hypertension management.

PubMed ID: 10619573

DOI: 10.1016/s0895-7061(99)00103-x

PubMed ID: 10969042

Title: A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.

PubMed ID: 10969042

DOI: 10.1161/01.res.87.5.e1

PubMed ID: 11815627

Title: Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.

PubMed ID: 11815627

DOI: 10.1074/jbc.m200581200

PubMed ID: 12045255

Title: Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.

PubMed ID: 12045255

DOI: 10.1172/jci14276

PubMed ID: 15283675

Title: Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism.

PubMed ID: 15283675

DOI: 10.1042/bj20040634

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17138938

Title: Mass-spectrometric identification of a novel angiotensin peptide in human plasma.

PubMed ID: 17138938

DOI: 10.1161/01.atv.0000253889.09765.5f

PubMed ID: 18793332

Title: Renin-angiotensin system revisited.

PubMed ID: 18793332

DOI: 10.1111/j.1365-2796.2008.01981.x

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9492317

Title: The octapeptide angiotensin II adopts a well-defined structure in a phospholipid environment.

PubMed ID: 9492317

DOI: 10.1046/j.1432-1327.1998.2510448.x

PubMed ID: 12752436

Title: Comparison of the solution structures of angiotensin I & II. Implication for structure-function relationship.

PubMed ID: 12752436

DOI: 10.1046/j.1432-1033.2003.03573.x

PubMed ID: 20927107

Title: A redox switch in angiotensinogen modulates angiotensin release.

PubMed ID: 20927107

DOI: 10.1038/nature09505

PubMed ID: 1394429

Title: Molecular basis of human hypertension: role of angiotensinogen.

PubMed ID: 1394429

DOI: 10.1016/0092-8674(92)90275-h

PubMed ID: 8513325

Title: A molecular variant of angiotensinogen associated with preeclampsia.

PubMed ID: 8513325

DOI: 10.1038/ng0593-59

PubMed ID: 7744780

Title: A mutation of angiotensinogen in a patient with preeclampsia leads to altered kinetics of the renin-angiotensin system.

PubMed ID: 7744780

DOI: 10.1074/jbc.270.19.11430

PubMed ID: 8621667

Title: The natural mutation Y248C of human angiotensinogen leads to abnormal glycosylation and altered immunological recognition of the protein.

PubMed ID: 8621667

DOI: 10.1074/jbc.271.16.9838

PubMed ID: 16116425

Title: Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.

PubMed ID: 16116425

DOI: 10.1038/ng1623

Sequence Information:

  • Length: 476
  • Mass: 52070
  • Checksum: EF44870358ABAD90
  • Sequence:
    • MAPAGVSLRA TILCLLAWAG LAAGDRVYIH PFHLVIHNES TCEQLAKANA GKPKDPTFIP 
APIQAKTSPV DEKALQDQLV LVAAKLDTED KLRAAMVGML ANFLGFRIYG MHSELWGVVH 
GATVLSPTAV FGTLASLYLG ALDHTADRLQ AILGVPWKDK NCTSRLDAHK VLSALQAVQG 
LLVAQGRADS QAQLLLSTVV GVFTAPGLHL KQPFVQGLAL YTPVVLPRSL DFTELDVAAE 
KIDRFMQAVT GWKTGCSLMG ASVDSTLAFN TYVHFQGKMK GFSLLAEPQE FWVDNSTSVS 
VPMLSGMGTF QHWSDIQDNF SVTQVPFTES ACLLLIQPHY ASDLDKVEGL TFQQNSLNWM 
KKLSPRTIHL TMPQLVLQGS YDLQDLLAQA ELPAILHTEL NLQKLSNDRI RVGEVLNSIF 
FELEADEREP TESTQQLNKP EVLEVTLNRP FLFAVYDQSA TALHFLGRVA NPLSTA

Genular Protein ID: 1839707944

Symbol: B2R5S1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R5S1

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 8 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 485
  • Mass: 53212
  • Checksum: D2AD5269F0B9B260
  • Sequence:
    • MRKRAPQSEM APAGVSLRAT ILCLLAWAGL AAGDRVYIHP FHLVIHNEST CEQLAKANAG 
KPKDPTFIPA PIQAKTSPVD EKALQDQLVL VAAKLDTEDK LRAAMVGMLA NFLGFRIYGM 
HSELWGVVHG ATVLSPTAVF GTLASLYLGA LDHTADRLQA ILGVPWKDKN CTSRLDAHKV 
LSALQAVQGL LVAQDRADSQ AQLLLSTVVG VFTAPGLHLK QPFVQGLALY TPVVLPRSLD 
FTELDVAAEK IDRFMQAVTG WKTGCSLMGA SVDSTLAFNT YVHFQGKMKG FSLLAEPQEF 
WVDNSTSVSV PMLSGMGTFQ HWSDIQDNFS VTQVPFTESA CLLLIQPHYA SDLDKVEGLT 
FQQNSLNWMK KLSPRTIHLT MPQLVLQGSY DLQDLLAQAE LPAILHTELN LQKLSNDRIR 
VGEVLNSIFF ELEADEREPT ESTQQLNKPE VLEVTLNRPF LFAVYDQSAT ALHFLGRVAN 
PLSTA

Genular Protein ID: 1792447071

Symbol: B0ZBE2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0ZBE2 A0A024R3V3

Database IDs:

ARBA 10 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 GO 4 Gene3D 2 GenomeRNAi 1 HOGENOM 1 InterPro 8 MEROPS 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 485
  • Mass: 53154
  • Checksum: 5026C2DFB2DD236E
  • Sequence:
    • MRKRAPQSEM APAGVSLRAT ILCLLAWAGL AAGDRVYIHP FHLVIHNEST CEQLAKANAG 
KPKDPTFIPA PIQAKTSPVD EKALQDQLVL VAAKLDTEDK LRAAMVGMLA NFLGFRIYGM 
HSELWGVVHG ATVLSPTAVF GTLASLYLGA LDHTADRLQA ILGVPWKDKN CTSRLDAHKV 
LSALQAVQGL LVAQGRADSQ AQLLLSTVVG VFTAPGLHLK QPFVQGLALY TPVVLPRSLD 
FTELDVAAEK IDRFMQAVTG WKTGCSLMGA SVDSTLAFNT YVHFQGKMKG FSLLAEPQEF 
WVDNSTSVSV PMLSGMGTFQ HWSDIQDNFS VTQVPFTESA CLLLIQPHYA SDLDKVEGLT 
FQQNSLNWMK KLSPRTIHLT MPQLVLQGSY DLQDLLAQAE LPAILHTELN LQKLSNDRIR 
VGEVLNSIFF ELEADEREPT ESTQQLNKPE VLEVTLNRPF LFAVYDQSAT ALHFLGRVAN 
PLSTA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.