Details for: Oprm1

Gene ID: 18390

Symbol: Oprm1

Ensembl ID: ENSMUSG00000000766

Description: opioid receptor, mu 1

Associated with

Other Information

Genular Protein ID: 1071637087

Symbol: OPRM_MOUSE

Name: Mu-type opioid receptor

UniProtKB Accession Codes:

P42866 A1XGX3 A1XGX4 A1YAC3 A1YAC4 A5H7G2 Q4U2P4 Q4U2Q6 Q548C6 Q60768 Q6YC50 Q8CAN5 Q8CGW2 Q8CH73 Q8CH74 Q8CH75 Q8VBU3 Q8VBU6 Q8VBX8 Q8VI69 Q8VI70 Q8VI71 Q8VIN3 Q8VIN4 Q8VIN5 Q8VIN6 Q8VIP0 Q8VIP1 Q9JIY1 Q9R0D1 Q9R1L9 Q9R1M0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 9 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisProt 1 DrugCentral 1 EMBL 41 EMDB 7 Ensembl 16 ExpressionAtlas 1 GO 53 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 11 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 19 RNAct 1 Reactome 4 RefSeq 12 SAM 1 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 11 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 8090773

Title: Genomic structure analysis of promoter sequence of a mouse mu opioid receptor gene.

PubMed ID: 8090773

DOI: 10.1073/pnas.91.19.9081

PubMed ID: 7649256

Title: Antisense mapping the MOR-1 opioid receptor: evidence for alternative splicing and a novel morphine-6 beta-glucuronide receptor.

PubMed ID: 7649256

DOI: 10.1016/0014-5793(95)00757-z

PubMed ID: 7797593

Title: Characterization of the murine mu opioid receptor gene.

PubMed ID: 7797593

DOI: 10.1074/jbc.270.26.15877

PubMed ID: 10419560

Title: Identification and characterization of three new alternatively spliced mu-opioid receptor isoforms.

PubMed ID: 10419560

DOI: 10.1124/mol.56.2.396

PubMed ID: 10682855

Title: Isolation and expression of a novel alternatively spliced mu opioid receptor isoform, MOR-1F.

PubMed ID: 10682855

DOI: 10.1016/s0014-5793(00)01095-4

PubMed ID: 11160404

Title: The untranslated region of (mu)-opioid receptor mRNA contributes to reduced opioid sensitivity in CXBK mice.

PubMed ID: 11160404

DOI: 10.1523/jneurosci.21-04-01334.2001

PubMed ID: 11717463

Title: Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene.

PubMed ID: 11717463

DOI: 10.1073/pnas.241296098

PubMed ID: 15939800

Title: Identification of four novel exon 5 splice variants of the mouse mu-opioid receptor gene: functional consequences of C-terminal splicing.

PubMed ID: 15939800

DOI: 10.1124/mol.105.011858

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 17398041

Title: Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon.

PubMed ID: 17398041

DOI: 10.1016/j.gene.2007.02.004

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6933569

Title: Analgesic activity of the naturally occurring heptapeptide [Met]enkephalin-Arg6-Phe7.

PubMed ID: 6933569

DOI: 10.1073/pnas.77.9.5512

PubMed ID: 9037090

Title: Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia.

PubMed ID: 9037090

DOI: 10.1073/pnas.94.4.1544

PubMed ID: 9767386

Title: Influence of Gz and Gi2 transducer proteins in the affinity of opioid agonists to mu receptors.

PubMed ID: 9767386

DOI: 10.1046/j.1460-9568.1998.00267.x

PubMed ID: 10842167

Title: Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties.

PubMed ID: 10842167

DOI: 10.1074/jbc.m000345200

PubMed ID: 12270145

Title: Dimerization of morphine and orphanin FQ/nociceptin receptors: generation of a novel opioid receptor subtype.

PubMed ID: 12270145

DOI: 10.1016/s0006-291x(02)02258-1

PubMed ID: 12642578

Title: Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors.

PubMed ID: 12642578

DOI: 10.1074/jbc.m300525200

PubMed ID: 12939277

Title: A novel endocytic recycling signal that distinguishes the membrane trafficking of naturally occurring opioid receptors.

PubMed ID: 12939277

DOI: 10.1074/jbc.m304504200

PubMed ID: 14991152

Title: Genetic analysis of the murine mu opioid receptor: increased complexity of Oprm gene splicing.

PubMed ID: 14991152

DOI: 10.1007/s00109-003-0514-z

PubMed ID: 15827571

Title: The RGSZ2 protein exists in a complex with mu-opioid receptors and regulates the desensitizing capacity of Gz proteins.

PubMed ID: 15827571

DOI: 10.1038/sj.npp.1300726

PubMed ID: 16682964

Title: mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis.

PubMed ID: 16682964

DOI: 10.1038/sj.bjp.0706757

PubMed ID: 17725581

Title: RGS9-2 is a negative modulator of mu-opioid receptor function.

PubMed ID: 17725581

DOI: 10.1111/j.1471-4159.2007.04812.x

PubMed ID: 18439408

Title: Multiple actions of spinophilin regulate mu opioid receptor function.

PubMed ID: 18439408

DOI: 10.1016/j.neuron.2008.02.006

PubMed ID: 18836069

Title: Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4.

PubMed ID: 18836069

DOI: 10.1073/pnas.0804106105

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22000021

Title: Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids.

PubMed ID: 22000021

DOI: 10.1016/j.cell.2011.08.043

PubMed ID: 21153910

Title: The histidine triad nucleotide-binding protein 1 supports mu-opioid receptor-glutamate NMDA receptor cross-regulation.

PubMed ID: 21153910

DOI: 10.1007/s00018-010-0598-x

PubMed ID: 21422164

Title: Heteromerization of the mu- and delta-opioid receptors produces ligand-biased antagonism and alters mu-receptor trafficking.

PubMed ID: 21422164

DOI: 10.1124/jpet.111.179093

PubMed ID: 35201898

Title: Angiotensin-converting enzyme gates brain circuit-specific plasticity via an endogenous opioid.

PubMed ID: 35201898

DOI: 10.1126/science.abl5130

PubMed ID: 22437502

Title: Crystal structure of the micro-opioid receptor bound to a morphinan antagonist.

PubMed ID: 22437502

DOI: 10.1038/nature10954

PubMed ID: 26245379

Title: Structural insights into u-opioid receptor activation.

PubMed ID: 26245379

DOI: 10.1038/nature14886

Sequence Information:

  • Length: 398
  • Mass: 44421
  • Checksum: DFE1C758E2DA197E
  • Sequence:
    • MDSSAGPGNI SDCSDPLAPA SCSPAPGSWL NLSHVDGNQS DPCGPNRTGL GGSHSLCPQT 
GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK TATNIYIFNL ALADALATST 
LPFQSVNYLM GTWPFGNILC KIVISIDYYN MFTSIFTLCT MSVDRYIAVC HPVKALDFRT 
PRNAKIVNVC NWILSSAIGL PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA 
FIMPVLIITV CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV 
IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF CIPTSSTIEQ 
QNSARIRQNT REHPSTANTV DRTNHQLENL EAETAPLP

Genular Protein ID: 1545611948

Symbol: A0A0R4J0Z2_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4J0Z2

Database IDs:

AGR 1 ARBA 14 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneTree 1 InterPro 4 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 456
  • Mass: 51023
  • Checksum: 0007835FE66F7D56
  • Sequence:
    • MDSSAGPGNI SDCSDPLAPA SCSPAPGSWL NLSHVDGNQS DPCGPNRTGL GGSHSLCPQT 
GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK TATNIYIFNL ALADALATST 
LPFQSVNYLM GTWPFGNILC KIVISIDYYN MFTSIFTLCT MSVDRYIAVC HPVKALDFRT 
PRNAKIVNVC NWILSSAIGL PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA 
FIMPVLIITV CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV 
IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF CIPTSSTIEQ 
QNSARIRQNT REHPSTANTV DRTNHQIMKF EAIYPKLSFK SWALKYFTFI REKKRNTKAG 
ALPPLPTCHA GSPSQAHRGV AAWLLPLRHM GPSYPS

Genular Protein ID: 2287546664

Symbol: A1KZZ4_MOUSE

Name: N/A

UniProtKB Accession Codes:

A1KZZ4

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HOGENOM 1 InterPro 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PRINTS 1 Proteomes 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 222
  • Mass: 23776
  • Checksum: F6FDDC3D92DDB9EA
  • Sequence:
    • MDSSAGPGNI SDCSDPLAPA SCSPAPGSWL NLSHVDGNQS DPCGPNRTGL GGSHSLCPQT 
GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRVHRLH PHVLSSHMVL GEPAQNLCLH 
LRLHHAGPHH HCVLWTDDLT TQECPHAVGL QRKGQEPAQD HPDGAGGRGC IYCLLDPHPH 
LCHHQSTDHD SRNHFPDCFL ALLHCLGLHK QLPEPSSLCV PG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.