Genular: Defining Cellular Identity and Function

Details for: Orc2

Gene ID: 18393

Symbol: Orc2

Ensembl ID: ENSMUSG00000026037

Description: origin recognition complex, subunit 2

Associated with

Activation of atr in response to replication stress
(R-MMU-176187)
Activation of the pre-replicative complex
(R-MMU-68962)
Assembly of the orc complex at the origin of replication
(R-MMU-68616)
Assembly of the pre-replicative complex
(R-MMU-68867)
Cdc6 association with the orc:origin complex
(R-MMU-68689)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Dna replication pre-initiation
(R-MMU-69002)
G1/s transition
(R-MMU-69206)
G2/m checkpoints
(R-MMU-69481)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Orc1 removal from chromatin
(R-MMU-68949)
S phase
(R-MMU-69242)
Switching of origins to a post-replicative state
(R-MMU-69052)
Synthesis of dna
(R-MMU-69239)
Centrosome
(GO:0005813)
Chromatin
(GO:0000785)
Chromosome, telomeric region
(GO:0000781)
Dna replication
(GO:0006260)
Dna replication initiation
(GO:0006270)
Dna replication origin binding
(GO:0003688)
Heterochromatin
(GO:0000792)
Inner kinetochore
(GO:0000939)
Nuclear origin of replication recognition complex
(GO:0005664)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Origin recognition complex
(GO:0000808)

Other Information

Proteins

Origin recognition complex subunit 2
Q59IX1_MOUSE

Genular Protein ID: 1237446003

Symbol: ORC2_MOUSE

Name: Origin recognition complex subunit 2

UniProtKB Accession Codes:

Q60862

Database IDs:

Citations:

PubMed ID: 8808289

Title: Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L.

PubMed ID: 8808289

DOI: 10.1006/geno.1996.0018

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12614612

Title: Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.

PubMed ID: 12614612

DOI: 10.1016/s0022-2836(03)00079-2

Sequence Information:

Length: 576
Mass: 65893
Checksum: A18BA2D18E72553B
Sequence:

MSTLQLKETK VPSVQFVGDD DVLSHILDRE GGTKLKKEKA QLLVNPQKVI KKADCELEKS 
DLEVLEDQNY VKVLGRNIQE SLGNGSAKDG RNKVYSFQQR KHPEEMTKLA LELAKTSGKK 
DPLDSNDPEI TKNIAQKSKG HSTSEKAPLV NNNKTEFLST QPHNLRKRII ASRSHYDSES 
EYSASSSEDD EEATKDEEED TNVARLSQKS QGQNRLLPAP VSKETLPKKK KRDKASDLVE 
EYFEAHSSSK VLTSDRTLQR LRRARVDQKT LHNLLRKFVP SFSAEIERLN QQHEKLFHKW 
MLQLHLGFNI VLYGLGSKRD LLEKFRTTML QDSIHVVING YFPGVSVKSI LNSITEDVLS 
HVGTFQSVLD QRDWIINRFK EDSSLELFLL IHNLDSQMLR GDNSQQILGQ LSSLHNVYLI 
ASIDHLNAPL MWDHAKQSLY NWLWYETTTY SPYTEETSYE NSLLVKQSGS LPLSSLIHVL 
RSLTPNARGI FRLLMKFQLD NQDSPSYIGL SFQDFYQQCR EAFLVNSDLT LRAQLTEFRD 
HKLIRTKKGT DGVEYLLIPV DSGILADFLE KEEEEA

Genular Protein ID: 3540849318

Symbol: Q59IX1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q59IX1

Database IDs:

Citations:

PubMed ID: 15634681

Title: Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation.

PubMed ID: 15634681

DOI: 10.1074/jbc.M413280200

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 528
Mass: 60416
Checksum: 9A781B7BA31F6D51
Sequence:

MSTLQLKETK VPSVQFVGDD DVLSHILDRE GESLGNGSAK DGRNKVYSFQ QRKHPEEMTK 
LALELAKTSG KKDPLDSNDP EITKNIAQKS KGHSTSEKAP LVNNNKTEFL STQPHNLRKR 
IIASRSHYDS ESEYSASSSE DDEEATKDEE EDTNVARLSQ KSQGQNRLLP APVSKETLPK 
KKKRDKASDL VEEYFEAHSS SKVLTSDRTL QRLRRARVDQ KTLHNLLRKF VPSFSAEIER 
LNQQHEKLFH KWMLQLHLGF NIVLYGLGSK RDLLEKFRTT MLQDSIHVVI NGYFPGVSVK 
SILNSITEDV LSHVGTFQSV LDQRDWIINR FKEDSSLELF LLIHNLDSQM LRGDNSQQIL 
GQLSSLHNVY LIASIDHLNA PLMWDHAKQS LYNWLWYETT TYSPYTEETS YENSLLVKQS 
GSLPLSSLIH VLRSLTPNAR GIFRLLMKFQ LDNQDSPSYI GLSFQDFYQQ CREAFLVNSD 
LTLRAQLTEF RDHKLIRTKK GTDGVEYLLI PVDSGILADF LEKEEEEA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Orc2

Associated with

Other Information

Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L. PubMed ID: 8808289

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. PubMed ID: 12614612