Genular: Defining Cellular Identity and Function

Details for: Sqstm1

Gene ID: 18412

Symbol: Sqstm1

Ensembl ID: ENSMUSG00000015837

Description: sequestosome 1

Associated with

Cell death signalling via nrage, nrif and nade
(R-MMU-204998)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Cytokine signaling in immune system
(R-MMU-1280215)
Death receptor signaling
(R-MMU-73887)
Immune system
(R-MMU-168256)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 signaling
(R-MMU-9020702)
Keap1-nfe2l2 pathway
(R-MMU-9755511)
Nf-kb is activated and signals survival
(R-MMU-209560)
Nrif signals cell death from the nucleus
(R-MMU-205043)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
P75ntr recruits signalling complexes
(R-MMU-209543)
P75ntr signals via nf-kb
(R-MMU-193639)
Pink1-prkn mediated mitophagy
(R-MMU-5205685)
Selective autophagy
(R-MMU-9663891)
Signaling by interleukins
(R-MMU-449147)
Signal transduction
(R-MMU-162582)
Aggrephagy
(GO:0035973)
Aggresome
(GO:0016235)
Apoptotic process
(GO:0006915)
Autophagosome
(GO:0005776)
Autophagy
(GO:0006914)
Brown fat cell proliferation
(GO:0070342)
Cell differentiation
(GO:0030154)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Endosome
(GO:0005768)
Endosome organization
(GO:0007032)
Energy homeostasis
(GO:0097009)
Enzyme binding
(GO:0019899)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Inclusion body
(GO:0016234)
Intracellular membrane-bounded organelle
(GO:0043231)
Ionotropic glutamate receptor binding
(GO:0035255)
K63-linked polyubiquitin modification-dependent protein binding
(GO:0070530)
Lysosome
(GO:0005764)
Macroautophagy
(GO:0016236)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Mitophagy
(GO:0000423)
Molecular condensate scaffold activity
(GO:0140693)
Molecular sequestering activity
(GO:0140313)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of toll-like receptor 4 signaling pathway
(GO:0034144)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Non-membrane-bounded organelle assembly
(GO:0140694)
Nucleus
(GO:0005634)
P-body
(GO:0000932)
Pexophagy
(GO:0000425)
Phagophore assembly site
(GO:0000407)
Pml body
(GO:0016605)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of long-term synaptic potentiation
(GO:1900273)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein-containing complex binding
(GO:0044877)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein import into nucleus
(GO:0006606)
Protein kinase binding
(GO:0019901)
Protein kinase c binding
(GO:0005080)
Protein localization to perinuclear region of cytoplasm
(GO:1905719)
Protein phosphorylation
(GO:0006468)
Protein sequestering activity
(GO:0140311)
Protein targeting to vacuole involved in autophagy
(GO:0071211)
Regulation of canonical nf-kappab signal transduction
(GO:0043122)
Regulation of protein complex stability
(GO:0061635)
Response to mitochondrial depolarisation
(GO:0098780)
Sh2 domain binding
(GO:0042169)
Signaling adaptor activity
(GO:0035591)
Signaling receptor activity
(GO:0038023)
Temperature homeostasis
(GO:0001659)
Transcription by rna polymerase ii
(GO:0006366)
Transcription coregulator activity
(GO:0003712)
Ubiquitin-dependent protein binding
(GO:0140036)
Ubiquitin binding
(GO:0043130)
Ubiquitin protein ligase binding
(GO:0031625)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Sequestosome-1

Genular Protein ID: 1599712845

Symbol: SQSTM_MOUSE

Name: Sequestosome-1

UniProtKB Accession Codes:

Q64337 Q99JM8

Database IDs:

Citations:

PubMed ID: 8806656

Title: Murine peritoneal macrophages induce a novel 60-kDa protein with structural similarity to a tyrosine kinase p56lck-associated protein in response to oxidative stress.

PubMed ID: 8806656

DOI: 10.1006/bbrc.1996.1377

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9125146

Title: Low micromolar levels of hydrogen peroxide and proteasome inhibitors induce the 60-kDa A170 stress protein in murine peritoneal macrophages.

PubMed ID: 9125146

DOI: 10.1006/bbrc.1997.6221

PubMed ID: 9405250

Title: Phosphorylation of A170 stress protein by casein kinase II-like activity in macrophages.

PubMed ID: 9405250

DOI: 10.1006/bbrc.1997.7783

PubMed ID: 10458914

Title: Cloning, expression profile, and genomic organization of the mouse STAP/A170 gene.

PubMed ID: 10458914

DOI: 10.1006/geno.1999.5902

PubMed ID: 11162503

Title: Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells.

PubMed ID: 11162503

DOI: 10.1006/bbrc.2000.4107

PubMed ID: 12745069

Title: Activation of Nrf2 and accumulation of ubiquitinated A170 by arsenic in osteoblasts.

PubMed ID: 12745069

DOI: 10.1016/s0006-291x(03)00728-9

PubMed ID: 14960283

Title: The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis.

PubMed ID: 14960283

DOI: 10.1016/s1534-5807(03)00403-9

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 15890008

Title: Microarray expression profiling identifies early signaling transcripts associated with 6-OHDA-induced dopaminergic cell death.

PubMed ID: 15890008

DOI: 10.1089/ars.2005.7.639

PubMed ID: 16286508

Title: p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death.

PubMed ID: 16286508

DOI: 10.1083/jcb.200507002

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18382763

Title: Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.

PubMed ID: 18382763

DOI: 10.1172/jci34257

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 20495340

Title: Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy.

PubMed ID: 20495340

DOI: 10.4161/auto.6.5.12189

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20421418

Title: A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

PubMed ID: 20421418

DOI: 10.1128/mcb.00248-10

PubMed ID: 21551061

Title: A family of IFN-gamma-inducible 65-kD GTPases protects against bacterial infection.

PubMed ID: 21551061

DOI: 10.1126/science.1201711

PubMed ID: 22792322

Title: The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.

PubMed ID: 22792322

DOI: 10.1371/journal.pone.0040440

PubMed ID: 25040165

Title: Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.

PubMed ID: 25040165

DOI: 10.1111/febs.12905

PubMed ID: 18524774

Title: Structural basis for sorting mechanism of p62 in selective autophagy.

PubMed ID: 18524774

DOI: 10.1074/jbc.m802182200

PubMed ID: 20173742

Title: The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.

PubMed ID: 20173742

DOI: 10.1038/ncb2021

PubMed ID: 24011591

Title: Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.

PubMed ID: 24011591

DOI: 10.1016/j.molcel.2013.08.003

Sequence Information:

Length: 442
Mass: 48163
Checksum: ED4CCCA7741D35CA
Sequence:

MASFTVKAYL LGKEEATREI RRFSFCFSPE PEAEAQAAAG PGPCERLLSR VAVLFPTLRP 
GGFQAHYRDE DGDLVAFSSD EELTMAMSYV KDDIFRIYIK EKKECRREHR PPCAQEAPRN 
MVHPNVICDG CNGPVVGTRY KCSVCPDYDL CSVCEGKGLH REHSKLIFPN PFGHLSDSFS 
HSRWLRKLKH GHFGWPGWEM GPPGNWSPRP PRAGDGRPCP TAESASAPPE DPNVNFLKNV 
GESVAAALSP LGIEVDIDVE HGGKRSRLTP TTPESSSTGT EDKSNTQPSS CSSEVSKPDG 
AGEGPAQSLT EQMKKIALES VGQPEEQMES GNCSGGDDDW THLSSKEVDP STGELQSLQM 
PESEGPSSLD PSQEGPTGLK EAALYPHLPP EADPRLIESL SQMLSMGFSD EGGWLTRLLQ 
TKNYDIGAAL DTIQYSKHPP PL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sqstm1

Associated with

Other Information

Murine peritoneal macrophages induce a novel 60-kDa protein with structural similarity to a tyrosine kinase p56lck-associated protein in response to oxidative stress. PubMed ID: 8806656

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Low micromolar levels of hydrogen peroxide and proteasome inhibitors induce the 60-kDa A170 stress protein in murine peritoneal macrophages. PubMed ID: 9125146

Phosphorylation of A170 stress protein by casein kinase II-like activity in macrophages. PubMed ID: 9405250

Cloning, expression profile, and genomic organization of the mouse STAP/A170 gene. PubMed ID: 10458914

Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells. PubMed ID: 11162503

Activation of Nrf2 and accumulation of ubiquitinated A170 by arsenic in osteoblasts. PubMed ID: 12745069

The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. PubMed ID: 14960283

Phosphoproteomic analysis of the developing mouse brain. PubMed ID: 15345747

Microarray expression profiling identifies early signaling transcripts associated with 6-OHDA-induced dopaminergic cell death. PubMed ID: 15890008

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. PubMed ID: 16286508

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. PubMed ID: 18382763

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. PubMed ID: 20495340

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. PubMed ID: 20421418

A family of IFN-gamma-inducible 65-kD GTPases protects against bacterial infection. PubMed ID: 21551061

The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PubMed ID: 22792322

Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1. PubMed ID: 25040165

Structural basis for sorting mechanism of p62 in selective autophagy. PubMed ID: 18524774

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. PubMed ID: 20173742

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. PubMed ID: 24011591