Genular: Defining Cellular Identity and Function

Details for: P2rx7

Gene ID: 18439

Symbol: P2rx7

Ensembl ID: ENSMUSG00000029468

Description: purinergic receptor P2X, ligand-gated ion channel, 7

Associated with

Elevation of cytosolic ca2+ levels
(R-MMU-139853)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Inflammasomes
(R-MMU-622312)
Innate immune system
(R-MMU-168249)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-MMU-168643)
Platelet calcium homeostasis
(R-MMU-418360)
Platelet homeostasis
(R-MMU-418346)
The nlrp3 inflammasome
(R-MMU-844456)
Atp binding
(GO:0005524)
Bleb assembly
(GO:0032060)
Calcium ion transport
(GO:0006816)
Cell morphogenesis
(GO:0000902)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to extracellular stimulus
(GO:0031668)
Cell volume homeostasis
(GO:0006884)
Channel activity
(GO:0015267)
Collagen metabolic process
(GO:0032963)
Copper ion binding
(GO:0005507)
Extracellularly atp-gated monoatomic cation channel activity
(GO:0004931)
Gamma-aminobutyric acid secretion
(GO:0014051)
Gene expression
(GO:0010467)
Glutamate secretion
(GO:0014047)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Interleukin-1 alpha production
(GO:0032610)
Interleukin-1 beta production
(GO:0032611)
Interleukin-6 production
(GO:0032635)
Lipopolysaccharide binding
(GO:0001530)
Macrophage cytokine production
(GO:0010934)
Magnesium ion binding
(GO:0000287)
Mapk cascade
(GO:0000165)
Membrane protein ectodomain proteolysis
(GO:0006509)
Mitochondrion organization
(GO:0007005)
Monoatomic cation transport
(GO:0006812)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Nad transport
(GO:0043132)
Neuronal action potential
(GO:0019228)
Phagolysosome assembly
(GO:0001845)
Phospholipid transfer to membrane
(GO:0006649)
Plasma membrane organization
(GO:0007009)
Plasma membrane phospholipid scrambling
(GO:0017121)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of calcium ion transport into cytosol
(GO:0010524)
Positive regulation of catalytic activity
(GO:0043085)
Positive regulation of gamma-aminobutyric acid secretion
(GO:0014054)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glutamate secretion
(GO:0014049)
Positive regulation of interleukin-1 alpha production
(GO:0032730)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of monoatomic ion transmembrane transport
(GO:0034767)
Positive regulation of prostaglandin secretion
(GO:0032308)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Programmed cell death
(GO:0012501)
Prostaglandin secretion
(GO:0032310)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein phosphorylation
(GO:0006468)
Protein processing
(GO:0016485)
Protein secretion
(GO:0009306)
Protein serine/threonine kinase activator activity
(GO:0043539)
Purinergic nucleotide receptor activity
(GO:0001614)
Purinergic nucleotide receptor signaling pathway
(GO:0035590)
Regulation of sodium ion transport
(GO:0002028)
Response to atp
(GO:0033198)
Response to bacterium
(GO:0009617)
Response to fluid shear stress
(GO:0034405)
Response to lipopolysaccharide
(GO:0032496)
Response to mechanical stimulus
(GO:0009612)
Response to organic cyclic compound
(GO:0014070)
Response to organic substance
(GO:0010033)
Response to xenobiotic stimulus
(GO:0009410)
Response to zinc ion
(GO:0010043)
Scaffold protein binding
(GO:0097110)
Sensory perception of pain
(GO:0019233)
Signaling receptor activity
(GO:0038023)
Signaling receptor binding
(GO:0005102)
Synaptic vesicle exocytosis
(GO:0016079)
T cell homeostasis
(GO:0043029)
T cell mediated cytotoxicity
(GO:0001913)
T cell proliferation
(GO:0042098)
Vesicle budding from membrane
(GO:0006900)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Genular Protein ID: 3609320240

Symbol: P2RX7_MOUSE

Name: P2X purinoceptor 7

UniProtKB Accession Codes:

Q9Z1M0

Database IDs:

Citations:

PubMed ID: 9849870

Title: Cloning and functional characterisation of the mouse P2X7 receptor.

PubMed ID: 9849870

DOI: 10.1016/s0014-5793(98)01332-5

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 17928361

Title: ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site.

PubMed ID: 17928361

DOI: 10.1096/fj.07-9294com

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 595
Mass: 68388
Checksum: BE007FE195AF50A4
Sequence:

MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL YQRKEPVISS 
VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN SFFVMTNYVK SEGQVQTLCP 
EYPRRGAQCS SDRRCKKGWM DPQSKGIQTG RCVPYDKTRK TCEVSAWCPT EEEKEAPRPA 
LLRSAENFTV LIKNNIHFPG HNYTTRNILP TMNGSCTFHK TWDPQCSIFR LGDIFQEAGE 
NFTEVAVQGG IMGIEIYWDC NLDSWSHHCR PRYSFRRLDD KNTDESFVPG YNFRYAKYYK 
ENNVEKRTLI KAFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLATVC IDLLINTYSS 
AFCRSGVYPY CKCCEPCTVN EYYYRKKCES IMEPKPTLKY VSFVDEPHIR MVDQQLLGKS 
LQVVKGQEVP RPQMDFSDLS RLSLSLHDSP LTPGQSEEIQ LLHEEVAPKS GDSPSWCQCG 
NCLPSRLPEQ RRALEELCCR RKPGRCITTS KLFHKLVLSR DTLQLLLLYQ DPLLVLGEEA 
TNSRLRHRAY RCYATWRFGS QDMADFAILP SCCRWRIRKE FPKTEGQYSG FKYPY

Genular Protein ID: 899978028

Symbol: Q3UN00_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UN00

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 431
Mass: 49368
Checksum: 7935E3F02AF82FA0
Sequence:

MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL YQRKEPVISS 
VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN SFFVMTNYVK SEGQVQTLCP 
EYPRRGAQCS SDRRCKKGWM DPQSKGIQTG RCVPYDKTRK TCEVSAWCPT EEEKEAPRPA 
LLRSAENFTV LIKNNIHFPG HNYTTRNILP TMNGSCTFHK TWDPQCSIFR LGDIFQEAGE 
NFTEVAVQGG IMGIEIYWDC NLDSWSHHCR PRYSFRRLDD KNTDESFVPG YNFRYAKYYK 
ENNVEKRTLI KAFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLATVC IDLLINTYSS 
AFCRSGVYPY CKCCEPCTVN EYYYRKKCES IMEPKPTLKY VSFVDEPHIR MVDQQLLGKS 
LQVVKGQEVP T

Genular Protein ID: 553461191

Symbol: F8WI93_MOUSE

Name: N/A

UniProtKB Accession Codes:

F8WI93

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 442
Mass: 50679
Checksum: C7B6166B3231AE16
Sequence:

MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL YQRKEPVISS 
VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN SFFVMTNYVK SEGQVQTLCP 
EYPRRGAQCS SDRRCKKGWM DPQSKGIQTG RCVPYDKTRK TCEVSAWCPT EEEKEAPRPA 
LLRSAENFTV LIKNNIHFPG HNYTTRNILP TMNGSCTFHK TWDPQCSIFR LGDIFQEAGE 
NFTEVAVQGG IMGIEIYWDC NLDSWSHHCR PRYSFRRLDD KNTDESFVPG YNFRYAKYYK 
ENNVEKRTLI KAFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLATVC IDLLINTYSS 
AFCRSGVYPY CKCCEPCTVN EYYYRKKCES IMEPKPTLKY VSFVDEPHIR MVDQQLLGKS 
LQVVKGQEVP VRVLCLHVCM RT

Genular Protein ID: 3635343425

Symbol: C8YIX4_MOUSE

Name: N/A

UniProtKB Accession Codes:

C8YIX4

Database IDs:

Citations:

PubMed ID: 19546214

Title: A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice.

PubMed ID: 19546214

DOI: 10.1074/jbc.M109.033134

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 592
Mass: 67774
Checksum: 32FF3585753E2660
Sequence:

MLPVSHLCSH KSGKVLEIHS IWIGTLKNTF LGAICVYICF ALVSDKLYQR KEPVISSVHT 
KVKGIAEVTE NVTEGGVTKL GHSIFDTADY TFPLQGNSFF VMTNYVKSEG QVQTLCPEYP 
RRGAQCSSDR RCKKGWMDPQ SKGIQTGRCV PYDKTRKTCE VSAWCPTEEE KEAPRPALLR 
SAENFTVLIK NNIHFPGHNY TTRNILPTMN GSCTFHKTWD PQCSIFRLGD IFQEAGENFT 
EVAVQGGIMG IEIYWDCNLD SWSHHCRPRY SFRRLDDKNT DESFVPGYNF RYAKYYKENN 
VEKRTLIKAF GIRFDILVFG TGGKFDIIQL VVYIGSTLSY FGLATVCIDL LINTYSSAFC 
RSGVYPYCKC CEPCTVNEYY YRKKCESIME PKPTLKYVSF VDEPHIRMVD QQLLGKSLQV 
VKGQEVPRPQ MDFSDLSRLS LSLHDSPLTP GQSEEIQLLH EEVAPKSGDS PSWCQCGNCL 
PSRLPEQRRA LEELCCRRKP GRCITTSKLF HKLVLSRDTL QLLLLYQDPL LVLGEEATNS 
RLRHRAYRCY ATWRFGSQDM ADFAILPSCC RWRIRKEFPK TEGQYSGFKY PY

Genular Protein ID: 1831222233

Symbol: Q6P5P0_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q6P5P0

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 153
Mass: 17199
Checksum: 05917407370B40CE
Sequence:

MPACCSWNDV LQYETNKVTR IQSTNYGTVK WVLHMIVFSY ISFALVSDKL YQRKEPVISS 
VHTKVKGIAE VTENVTEGGV TKLGHSIFDT ADYTFPLQGN SFFVMTNYVK SEGQVQTLCP 
EDLSNLQESN QTSKPLLRNP RAKKEEGLSL ELA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: P2rx7

Associated with

Other Information

Cloning and functional characterisation of the mouse P2X7 receptor. PubMed ID: 9849870

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site. PubMed ID: 17928361

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice. PubMed ID: 19546214

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Database document:

PubMed ID: 9849870

PubMed ID: 19468303

PubMed ID: 17928361

PubMed ID: 19349973

PubMed ID: 21183079

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073

PubMed ID: 19468303

PubMed ID: 21183079

PubMed ID: 19468303

PubMed ID: 21183079

PubMed ID: 19546214

PubMed ID: 19468303

PubMed ID: 15489334

PubMed ID: 19468303