Genular: Defining Cellular Identity and Function

Details for: P4hb

Gene ID: 18453

Symbol: P4hb

Ensembl ID: ENSMUSG00000025130

Description: prolyl 4-hydroxylase, beta polypeptide

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Chylomicron assembly
(R-MMU-8963888)
Collagen biosynthesis and modifying enzymes
(R-MMU-1650814)
Collagen formation
(R-MMU-1474290)
Cytokine signaling in immune system
(R-MMU-1280215)
Detoxification of reactive oxygen species
(R-MMU-3299685)
Extracellular matrix organization
(R-MMU-1474244)
Hedgehog ligand biogenesis
(R-MMU-5358346)
Immune system
(R-MMU-168256)
Interleukin-12 family signaling
(R-MMU-447115)
Interleukin-12 signaling
(R-MMU-9020591)
Interleukin-23 signaling
(R-MMU-9020933)
Ldl remodeling
(R-MMU-8964041)
Metabolism of proteins
(R-MMU-392499)
Peptide hormone metabolism
(R-MMU-2980736)
Plasma lipoprotein assembly
(R-MMU-8963898)
Plasma lipoprotein assembly, remodeling, and clearance
(R-MMU-174824)
Plasma lipoprotein remodeling
(R-MMU-8963899)
Post-translational protein modification
(R-MMU-597592)
Post-translational protein phosphorylation
(R-MMU-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-MMU-381426)
Signaling by hedgehog
(R-MMU-5358351)
Signaling by interleukins
(R-MMU-449147)
Signal transduction
(R-MMU-162582)
Transport of small molecules
(R-MMU-382551)
Vldl assembly
(R-MMU-8866423)
Actin binding
(GO:0003779)
Cellular response to hypoxia
(GO:0071456)
Cellular response to interleukin-7
(GO:0098761)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum-golgi intermediate compartment
(GO:0005793)
Endoplasmic reticulum chaperone complex
(GO:0034663)
Endoplasmic reticulum lumen
(GO:0005788)
Endoplasmic reticulum to golgi vesicle-mediated transport
(GO:0006888)
Enzyme binding
(GO:0019899)
External side of plasma membrane
(GO:0009897)
Insulin processing
(GO:0030070)
Integrin binding
(GO:0005178)
Isomerase activity
(GO:0016853)
Lamellipodium
(GO:0030027)
Membrane
(GO:0016020)
Peptidyl-proline hydroxylation to 4-hydroxy-l-proline
(GO:0018401)
Plasma membrane
(GO:0005886)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of substrate adhesion-dependent cell spreading
(GO:1900026)
Positive regulation of viral entry into host cell
(GO:0046598)
Procollagen-proline 4-dioxygenase activity
(GO:0004656)
Procollagen-proline 4-dioxygenase complex
(GO:0016222)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein-disulfide reductase activity
(GO:0015035)
Protein binding
(GO:0005515)
Protein disulfide isomerase activity
(GO:0003756)
Protein folding
(GO:0006457)
Protein folding in endoplasmic reticulum
(GO:0034975)
Protein heterodimerization activity
(GO:0046982)
Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
(GO:1902175)
Response to endoplasmic reticulum stress
(GO:0034976)
Thiol oxidase activity
(GO:0016972)

Other Information

Proteins

Protein disulfide-isomerase

Genular Protein ID: 2059506146

Symbol: PDIA1_MOUSE

Name: Protein disulfide-isomerase

UniProtKB Accession Codes:

P09103 Q922C8

Database IDs:

Citations:

PubMed ID: 2830592

Title: Nucleotide sequence of a full-length cDNA clone encoding a mouse cellular thyroid hormone binding protein (p55) that is homologous to protein disulfide isomerase and the beta-subunit of prolyl-4-hydroxylase.

PubMed ID: 2830592

DOI: 10.1093/nar/16.3.1203

PubMed ID: 2295602

Title: ERp72, an abundant luminal endoplasmic reticulum protein, contains three copies of the active site sequences of protein disulfide isomerase.

PubMed ID: 2295602

DOI: 10.1016/s0021-9258(19)40163-4

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7753822

Title: Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit.

PubMed ID: 7753822

DOI: 10.1073/pnas.92.10.4427

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21670307

Title: Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry.

PubMed ID: 21670307

DOI: 10.1073/pnas.1017954108

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 29858230

Title: Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1alpha.

PubMed ID: 29858230

DOI: 10.15252/embj.201798699

PubMed ID: 32149426

Title: Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.

PubMed ID: 32149426

DOI: 10.15252/embj.2019103841

PubMed ID: 33863978

Title: ILDR2 stabilization is regulated by its interaction with GRP78.

PubMed ID: 33863978

DOI: 10.1038/s41598-021-87884-7

Sequence Information:

Length: 509
Mass: 57058
Checksum: 1FB0AA8ACCDB13EA
Sequence:

MLSRALLCLA LAWAARVGAD ALEEEDNVLV LKKSNFEEAL AAHKYLLVEF YAPWCGHCKA 
LAPEYAKAAA KLKAEGSEIR LAKVDATEES DLAQQYGVRG YPTIKFFKNG DTASPKEYTA 
GREADDIVNW LKKRTGPAAT TLSDTAAAES LVDSSEVTVI GFFKDVESDS AKQFLLAAEA 
IDDIPFGITS NSGVFSKYQL DKDGVVLFKK FDEGRNNFEG EITKEKLLDF IKHNQLPLVI 
EFTEQTAPKI FGGEIKTHIL LFLPKSVSDY DGKLSSFKRA AEGFKGKILF IFIDSDHTDN 
QRILEFFGLK KEECPAVRLI TLEEEMTKYK PESDELTAEK ITEFCHRFLE GKIKPHLMSQ 
EVPEDWDKQP VKVLVGANFE EVAFDEKKNV FVEFYAPWCG HCKQLAPIWD KLGETYKDHE 
NIIIAKMDST ANEVEAVKVH SFPTLKFFPA SADRTVIDYN GERTLDGFKK FLESGGQDGA 
GDDEDLDLEE ALEPDMEEDD DQKAVKDEL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: P4hb

Associated with

Other Information

Nucleotide sequence of a full-length cDNA clone encoding a mouse cellular thyroid hormone binding protein (p55) that is homologous to protein disulfide isomerase and the beta-subunit of prolyl-4-hydroxylase. PubMed ID: 2830592

ERp72, an abundant luminal endoplasmic reticulum protein, contains three copies of the active site sequences of protein disulfide isomerase. PubMed ID: 2295602

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit. PubMed ID: 7753822

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry. PubMed ID: 21670307

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1alpha. PubMed ID: 29858230

Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress. PubMed ID: 32149426

ILDR2 stabilization is regulated by its interaction with GRP78. PubMed ID: 33863978