Genular: Defining Cellular Identity and Function

Details for: Pabpc1

Gene ID: 18458

Symbol: Pabpc1

Ensembl ID: ENSMUSG00000022283

Description: poly(A) binding protein, cytoplasmic 1

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-MMU-72662)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-MMU-450408)
Cap-dependent translation initiation
(R-MMU-72737)
Deadenylation-dependent mrna decay
(R-MMU-429914)
Deadenylation of mrna
(R-MMU-429947)
Eukaryotic translation initiation
(R-MMU-72613)
L13a-mediated translational silencing of ceruloplasmin expression
(R-MMU-156827)
Metabolism of proteins
(R-MMU-392499)
Metabolism of rna
(R-MMU-8953854)
Nonsense-mediated decay (nmd)
(R-MMU-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-MMU-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-MMU-975956)
Regulation of mrna stability by proteins that bind au-rich elements
(R-MMU-450531)
Translation
(R-MMU-72766)
Translation initiation complex formation
(R-MMU-72649)
Catalytic step 2 spliceosome
(GO:0071013)
Cell leading edge
(GO:0031252)
Cell projection
(GO:0042995)
Cytoplasm
(GO:0005737)
Cytoplasmic ribonucleoprotein granule
(GO:0036464)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Mcrd-mediated mrna stability complex
(GO:0106002)
Messenger ribonucleoprotein complex
(GO:1990124)
Mrna 3'-utr binding
(GO:0003730)
Mrna binding
(GO:0003729)
Mrna processing
(GO:0006397)
Nuclear-transcribed mrna catabolic process, nonsense-mediated decay
(GO:0000184)
Nucleic acid binding
(GO:0003676)
Nucleus
(GO:0005634)
Poly(a) binding
(GO:0008143)
Poly(u) rna binding
(GO:0008266)
Positive regulation of nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
(GO:1900153)
Positive regulation of nuclear-transcribed mrna poly(a) tail shortening
(GO:0060213)
Protein binding
(GO:0005515)
Regulatory ncrna-mediated gene silencing
(GO:0031047)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Rna splicing
(GO:0008380)
Spliceosomal complex
(GO:0005681)
Synapse
(GO:0045202)

Other Information

Proteins

Polyadenylate-binding protein 1

Genular Protein ID: 126839753

Symbol: PABP1_MOUSE

Name: Polyadenylate-binding protein 1

UniProtKB Accession Codes:

P29341 Q99L36

Database IDs:

Citations:

PubMed ID: 1630930

Title: Nucleotide sequence of a mouse testis poly(A) binding protein cDNA.

PubMed ID: 1630930

DOI: 10.1093/nar/20.13.3519

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10076007

Title: The mouse Y-box protein, MSY2, is associated with a kinase on non-polysomal mouse testicular mRNAs.

PubMed ID: 10076007

DOI: 10.1093/nar/27.7.1747

PubMed ID: 15314026

Title: UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.

PubMed ID: 15314026

DOI: 10.1101/gad.1219104

PubMed ID: 17927953

Title: Disruption of mouse poly(A) polymerase mGLD-2 does not alter polyadenylation status in oocytes and somatic cells.

PubMed ID: 17927953

DOI: 10.1016/j.bbrc.2007.09.096

PubMed ID: 19020299

Title: Characterization of two cytoplasmic poly(A)-binding proteins, PABPC1 and PABPC2, in mouse spermatogenic cells.

PubMed ID: 19020299

DOI: 10.1095/biolreprod.108.072553

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 36001654

Title: RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis.

PubMed ID: 36001654

DOI: 10.1126/sciadv.abq2945

Sequence Information:

Length: 636
Mass: 70671
Checksum: E5BB6D5BA4F86CB7
Sequence:

MNPSAPSYPM ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RVCRDMITRR SLGYAYVNFQ 
QPADAERALD TMNFDVIKGK PVRIMWSQRD PSLRKSGVGN IFIKNLDKSI DNKALYDTFS 
AFGNILSCKV VCDENGSKGY GFVHFETQEA AERAIEKMNG MLLNDRKVFV GRFKSRKERE 
AELGARAKEF TNVYIKNFGE DMDDERLKEL FGKFGPALSV KVMTDESGKS KGFGFVSFER 
HEDAQKAVDE MNGKELNGKQ IYVGRAQKKV ERQTELKRKF EQMKQDRITR YQGVNLYVKN 
LDDGIDDERL RKEFSPFGTI TSAKVMMEGG RSKGFGFVCF SSPEEATKAV TEMNGRIVAT 
KPLYVALAQR KEERQAHLTN QYMQRMASVR AVPNPVINPY QPAPPSGYFM AAIPQTQNRA 
AYYPPSQIAQ LRPSPRWTAQ GARPHPFQNM PGAIRPAAPR PPFSTMRPAS SQVPRVMSTQ 
RVANTSTQTM GPRPAAAAAA ATPAVRTVPQ YKYAAGVRNP QQHLNAQPQV TMQQPAVHVQ 
GQEPLTASML ASAPPQEQKQ MLGERLFPLI QAMHPSLAGK ITGMLLEIDN SELLHMLESP 
ESLRSKVDEA VAVLQAHQAK EAAQKAVNSA TGVPTV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pabpc1

Associated with

Other Information

Nucleotide sequence of a mouse testis poly(A) binding protein cDNA. PubMed ID: 1630930

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The mouse Y-box protein, MSY2, is associated with a kinase on non-polysomal mouse testicular mRNAs. PubMed ID: 10076007

UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant. PubMed ID: 15314026

Disruption of mouse poly(A) polymerase mGLD-2 does not alter polyadenylation status in oocytes and somatic cells. PubMed ID: 17927953

Characterization of two cytoplasmic poly(A)-binding proteins, PABPC1 and PABPC2, in mouse spermatogenic cells. PubMed ID: 19020299

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis. PubMed ID: 36001654