Genular: Defining Cellular Identity and Function

Details for: Pafah1b1

Gene ID: 18472

Symbol: Pafah1b1

Ensembl ID: ENSMUSG00000020745

Description: platelet-activating factor acetylhydrolase, isoform 1b, subunit 1

Associated with

Amplification of signal from the kinetochores
(R-MMU-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-MMU-141444)
Anchoring of the basal body to the plasma membrane
(R-MMU-5620912)
Aurka activation by tpx2
(R-MMU-8854518)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Centrosome maturation
(R-MMU-380287)
Cilium assembly
(R-MMU-5617833)
Copi-independent golgi-to-er retrograde traffic
(R-MMU-6811436)
Eml4 and nudc in mitotic spindle formation
(R-MMU-9648025)
G2/m transition
(R-MMU-69275)
Golgi-to-er retrograde transport
(R-MMU-8856688)
Intra-golgi and retrograde golgi-to-er traffic
(R-MMU-6811442)
Loss of nlp from mitotic centrosomes
(R-MMU-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-MMU-380284)
Membrane trafficking
(R-MMU-199991)
Mitotic anaphase
(R-MMU-68882)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic metaphase and anaphase
(R-MMU-2555396)
Mitotic prometaphase
(R-MMU-68877)
Mitotic spindle checkpoint
(R-MMU-69618)
M phase
(R-MMU-68886)
Organelle biogenesis and maintenance
(R-MMU-1852241)
Recruitment of mitotic centrosome proteins and complexes
(R-MMU-380270)
Recruitment of numa to mitotic centrosomes
(R-MMU-380320)
Regulation of plk1 activity at g2/m transition
(R-MMU-2565942)
Resolution of sister chromatid cohesion
(R-MMU-2500257)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate formins
(R-MMU-5663220)
Separation of sister chromatids
(R-MMU-2467813)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Vesicle-mediated transport
(R-MMU-5653656)
Acrosome assembly
(GO:0001675)
Actin cytoskeleton organization
(GO:0030036)
Adult locomotory behavior
(GO:0008344)
Ameboidal-type cell migration
(GO:0001667)
Brain morphogenesis
(GO:0048854)
Cell cycle
(GO:0007049)
Cell differentiation
(GO:0030154)
Cell migration
(GO:0016477)
Cerebral cortex development
(GO:0021987)
Cerebral cortex neuron differentiation
(GO:0021895)
Chemical synaptic transmission
(GO:0007268)
Corpus callosum morphogenesis
(GO:0021540)
Cortical microtubule organization
(GO:0043622)
Dynein complex binding
(GO:0070840)
Dynein intermediate chain binding
(GO:0045505)
Establishment of mitotic spindle orientation
(GO:0000132)
Establishment of planar polarity of embryonic epithelium
(GO:0042249)
Germ cell development
(GO:0007281)
Hippocampus development
(GO:0021766)
Identical protein binding
(GO:0042802)
Jnk cascade
(GO:0007254)
Layer formation in cerebral cortex
(GO:0021819)
Learning or memory
(GO:0007611)
Lipid catabolic process
(GO:0016042)
Lipid metabolic process
(GO:0006629)
Microtubule-based process
(GO:0007017)
Microtubule binding
(GO:0008017)
Microtubule cytoskeleton organization
(GO:0000226)
Microtubule organizing center organization
(GO:0031023)
Microtubule plus-end binding
(GO:0051010)
Modulation of chemical synaptic transmission
(GO:0050804)
Multicellular organism development
(GO:0007275)
Negative regulation of jnk cascade
(GO:0046329)
Negative regulation of neuron projection development
(GO:0010977)
Nervous system development
(GO:0007399)
Neuroblast proliferation
(GO:0007405)
Neuromuscular process controlling balance
(GO:0050885)
Neuron migration
(GO:0001764)
Nuclear migration
(GO:0007097)
Osteoclast development
(GO:0036035)
Phosphoprotein binding
(GO:0051219)
Positive regulation of axon extension
(GO:0045773)
Positive regulation of cytokine-mediated signaling pathway
(GO:0001961)
Positive regulation of embryonic development
(GO:0040019)
Positive regulation of mitotic cell cycle
(GO:0045931)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein secretion
(GO:0009306)
Reelin-mediated signaling pathway
(GO:0038026)
Regulation of gtpase activity
(GO:0043087)
Retrograde axonal transport
(GO:0008090)
Stem cell division
(GO:0017145)
Transmission of nerve impulse
(GO:0019226)
Vesicle transport along microtubule
(GO:0047496)

Other Information

Proteins

LIS1_MOUSE

Genular Protein ID: 2634931602

Symbol: LIS1_MOUSE

Name: N/A

UniProtKB Accession Codes:

P63005 O35592 P43035 P81692 Q9R2A6

Database IDs:

Citations:

PubMed ID: 7821822

Title: Lissencephaly-1 is one of the most conserved proteins between mouse and human: a single amino-acid difference in 410 residues.

PubMed ID: 7821822

DOI: 10.1016/0378-1119(94)90468-5

PubMed ID: 9479492

Title: Cloning and characterization of cDNAs and the gene encoding the mouse platelet-activating factor acetylhydrolase Ib alpha subunit/lissencephaly-1 protein.

PubMed ID: 9479492

DOI: 10.1006/geno.1997.5121

PubMed ID: 7751941

Title: Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration.

PubMed ID: 7751941

DOI: 10.1523/jneurosci.15-05-03730.1995

PubMed ID: 11756344

Title: Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci.

PubMed ID: 11756344

DOI: 10.2337/diabetes.51.1.215

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11001923

Title: Interaction between LIS1 and doublecortin, two lissencephaly gene products.

PubMed ID: 11001923

DOI: 10.1093/oxfordjournals.hmg.a018911

PubMed ID: 11056530

Title: Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1.

PubMed ID: 11056530

DOI: 10.1038/35041000

PubMed ID: 11163258

Title: LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome.

PubMed ID: 11163258

DOI: 10.1016/s0896-6273(00)00145-8

PubMed ID: 11163259

Title: A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system.

PubMed ID: 11163259

DOI: 10.1016/s0896-6273(00)00146-x

PubMed ID: 11163260

Title: NUDEL is a novel cdk5 substrate that associates with LIS1 and cytoplasmic dynein.

PubMed ID: 11163260

DOI: 10.1016/s0896-6273(00)00147-1

PubMed ID: 11231056

Title: NudE-L, a novel Lis1-interacting protein, belongs to a family of vertebrate coiled-coil proteins.

PubMed ID: 11231056

DOI: 10.1016/s0925-4773(00)00543-8

PubMed ID: 11344260

Title: Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization.

PubMed ID: 11344260

DOI: 10.1073/pnas.101122598

PubMed ID: 11940666

Title: LIS1, CLIP-170's key to the dynein/dynactin pathway.

PubMed ID: 11940666

DOI: 10.1128/mcb.22.9.3089-3102.2002

PubMed ID: 12911752

Title: Involvement of platelet-activating factor and LIS1 in neuronal migration.

PubMed ID: 12911752

DOI: 10.1046/j.1460-9568.2003.02778.x

PubMed ID: 12551946

Title: Targeted disruption of intracellular type I platelet activating factor-acetylhydrolase catalytic subunits causes severe impairment in spermatogenesis.

PubMed ID: 12551946

DOI: 10.1074/jbc.m211836200

PubMed ID: 12885786

Title: LIS1 missense mutations: variable phenotypes result from unpredictable alterations in biochemical and cellular properties.

PubMed ID: 12885786

DOI: 10.1074/jbc.m301147200

PubMed ID: 14691133

Title: A role for cytoplasmic dynein and LIS1 in directed cell movement.

PubMed ID: 14691133

DOI: 10.1083/jcb.200310097

PubMed ID: 14507966

Title: Disregulated RhoGTPases and actin cytoskeleton contribute to the migration defect in Lis1-deficient neurons.

PubMed ID: 14507966

DOI: 10.1523/jneurosci.23-25-08673.2003

PubMed ID: 12950100

Title: A study of the nature of embryonic lethality in LIS1-/- mice.

PubMed ID: 12950100

DOI: 10.1002/mrd.10339

PubMed ID: 12796778

Title: 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome.

PubMed ID: 12796778

DOI: 10.1038/ng1169

PubMed ID: 14578885

Title: Interaction of reelin signaling and Lis1 in brain development.

PubMed ID: 14578885

DOI: 10.1038/ng1257

PubMed ID: 15147871

Title: Expression of NUDEL in manchette and its implication in spermatogenesis.

PubMed ID: 15147871

DOI: 10.1016/j.febslet.2004.04.009

PubMed ID: 15173193

Title: Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration.

PubMed ID: 15173193

DOI: 10.1083/jcb.200309025

PubMed ID: 15473966

Title: Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning.

PubMed ID: 15473966

DOI: 10.1016/j.neuron.2004.09.030

PubMed ID: 15473967

Title: Mitotic spindle regulation by Nde1 controls cerebral cortical size.

PubMed ID: 15473967

DOI: 10.1016/j.neuron.2004.09.023

PubMed ID: 16258276

Title: Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization.

PubMed ID: 16258276

DOI: 10.4161/cc.4.11.2151

PubMed ID: 16203747

Title: Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration.

PubMed ID: 16203747

DOI: 10.1093/hmg/ddi339

PubMed ID: 16107726

Title: Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality.

PubMed ID: 16107726

DOI: 10.1128/mcb.25.17.7812-7827.2005

PubMed ID: 15939891

Title: Cytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway.

PubMed ID: 15939891

DOI: 10.1073/pnas.0502303102

PubMed ID: 16481446

Title: Regulation of cytoplasmic dynein ATPase by Lis1.

PubMed ID: 16481446

DOI: 10.1523/jneurosci.5095-05.2006

PubMed ID: 16291865

Title: Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly.

PubMed ID: 16291865

DOI: 10.1091/mbc.e05-04-0360

PubMed ID: 16369480

Title: Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility.

PubMed ID: 16369480

DOI: 10.1038/nn1619

PubMed ID: 17330141

Title: The Pafah1b complex interacts with the reelin receptor VLDLR.

PubMed ID: 17330141

DOI: 10.1371/journal.pone.0000252

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23097494

Title: Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry.

PubMed ID: 23097494

DOI: 10.1091/mbc.e12-07-0558

PubMed ID: 15572112

Title: Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase.

PubMed ID: 15572112

DOI: 10.1016/j.neuron.2004.11.019

PubMed ID: 15274919

Title: The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications.

PubMed ID: 15274919

DOI: 10.1016/j.str.2004.03.024

Sequence Information:

Length: 410
Mass: 46670
Checksum: 4DBF6A24A6B131CD
Sequence:

MVLSQRQRDE LNRAIADYLR SNGYEEAYSV FKKEAELDMN EELDKKYAGL LEKKWTSVIR 
LQKKVMELES KLNEAKEEFT SGGPLGQKRD PKEWIPRPPE KYALSGHRSP VTRVIFHPVF 
SVMVSASEDA TIKVWDYETG DFERTLKGHT DSVQDISFDH SGKLLASCSA DMTIKLWDFQ 
GFECIRTMHG HDHNVSSVAI MPNGDHIVSA SRDKTIKMWE VQTGYCVKTF TGHREWVRMV 
RPNQDGTLIA SCSNDQTVRV WVVATKECKA ELREHEHVVE CISWAPESSY SSISEATGSE 
TKKSGKPGPF LLSGSRDKTI KMWDVSTGMC LMTLVGHDNW VRGVLFHSGG KFILSCADDK 
TLRVWDYKNK RCMKTLNAHE HFVTSLDFHK TAPYVVTGSV DQTVKVWECR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pafah1b1

Associated with

Other Information

Lissencephaly-1 is one of the most conserved proteins between mouse and human: a single amino-acid difference in 410 residues. PubMed ID: 7821822

Cloning and characterization of cDNAs and the gene encoding the mouse platelet-activating factor acetylhydrolase Ib alpha subunit/lissencephaly-1 protein. PubMed ID: 9479492

Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration. PubMed ID: 7751941

Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci. PubMed ID: 11756344

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Interaction between LIS1 and doublecortin, two lissencephaly gene products. PubMed ID: 11001923

Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1. PubMed ID: 11056530

LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome. PubMed ID: 11163258

A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system. PubMed ID: 11163259

NUDEL is a novel cdk5 substrate that associates with LIS1 and cytoplasmic dynein. PubMed ID: 11163260

NudE-L, a novel Lis1-interacting protein, belongs to a family of vertebrate coiled-coil proteins. PubMed ID: 11231056

Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization. PubMed ID: 11344260

LIS1, CLIP-170's key to the dynein/dynactin pathway. PubMed ID: 11940666

Involvement of platelet-activating factor and LIS1 in neuronal migration. PubMed ID: 12911752

Targeted disruption of intracellular type I platelet activating factor-acetylhydrolase catalytic subunits causes severe impairment in spermatogenesis. PubMed ID: 12551946

LIS1 missense mutations: variable phenotypes result from unpredictable alterations in biochemical and cellular properties. PubMed ID: 12885786

A role for cytoplasmic dynein and LIS1 in directed cell movement. PubMed ID: 14691133

Disregulated RhoGTPases and actin cytoskeleton contribute to the migration defect in Lis1-deficient neurons. PubMed ID: 14507966

A study of the nature of embryonic lethality in LIS1-/- mice. PubMed ID: 12950100

14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. PubMed ID: 12796778

Interaction of reelin signaling and Lis1 in brain development. PubMed ID: 14578885

Expression of NUDEL in manchette and its implication in spermatogenesis. PubMed ID: 15147871

Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration. PubMed ID: 15173193

Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning. PubMed ID: 15473966

Mitotic spindle regulation by Nde1 controls cerebral cortical size. PubMed ID: 15473967

Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization. PubMed ID: 16258276

Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. PubMed ID: 16203747

Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality. PubMed ID: 16107726

Cytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway. PubMed ID: 15939891

Regulation of cytoplasmic dynein ATPase by Lis1. PubMed ID: 16481446

Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly. PubMed ID: 16291865

Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility. PubMed ID: 16369480

The Pafah1b complex interacts with the reelin receptor VLDLR. PubMed ID: 17330141

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry. PubMed ID: 23097494

Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. PubMed ID: 15572112

The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications. PubMed ID: 15274919