Genular: Defining Cellular Identity and Function

Details for: Pak1

Gene ID: 18479

Symbol: Pak1

Ensembl ID: ENSMUSG00000030774

Description: p21 (RAC1) activated kinase 1

Associated with

Adaptive immune system
(R-MMU-1280218)
Axon guidance
(R-MMU-422475)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Cd28 co-stimulation
(R-MMU-389356)
Cd28 dependent vav1 pathway
(R-MMU-389359)
Cd209 (dc-sign) signaling
(R-MMU-5621575)
Costimulation by the cd28 family
(R-MMU-388841)
Developmental biology
(R-MMU-1266738)
Dscam interactions
(R-MMU-376172)
Eph-ephrin signaling
(R-MMU-2682334)
Ephb-mediated forward signaling
(R-MMU-3928662)
Ephrin signaling
(R-MMU-3928664)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated mapk activation
(R-MMU-2871796)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-MMU-2029480)
G-protein beta:gamma signalling
(R-MMU-397795)
G beta:gamma signalling through cdc42
(R-MMU-8964616)
Generation of second messenger molecules
(R-MMU-202433)
Gpcr downstream signalling
(R-MMU-388396)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
L1cam interactions
(R-MMU-373760)
Mapk6/mapk4 signaling
(R-MMU-5687128)
Mapk family signaling cascades
(R-MMU-5683057)
Muscle contraction
(R-MMU-397014)
Nervous system development
(R-MMU-9675108)
Netrin-1 signaling
(R-MMU-373752)
Rac1 gtpase cycle
(R-MMU-9013149)
Rac2 gtpase cycle
(R-MMU-9013404)
Rac3 gtpase cycle
(R-MMU-9013423)
Regulation of actin dynamics for phagocytic cup formation
(R-MMU-2029482)
Rho gtpase cycle
(R-MMU-9012999)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate paks
(R-MMU-5627123)
Rhoh gtpase cycle
(R-MMU-9013407)
Rhoq gtpase cycle
(R-MMU-9013406)
Rhou gtpase cycle
(R-MMU-9013420)
Rhov gtpase cycle
(R-MMU-9013424)
Sema3a pak dependent axon repulsion
(R-MMU-399954)
Semaphorin interactions
(R-MMU-373755)
Signaling by gpcr
(R-MMU-372790)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Signal transduction by l1
(R-MMU-445144)
Smooth muscle contraction
(R-MMU-445355)
Tcr signaling
(R-MMU-202403)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Vegfr2 mediated vascular permeability
(R-MMU-5218920)
Actin cytoskeleton organization
(GO:0030036)
Amygdala development
(GO:0021764)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Catalytic activity
(GO:0003824)
Cell migration
(GO:0016477)
Cellular response to insulin stimulus
(GO:0032869)
Chromatin remodeling
(GO:0006338)
Collagen binding
(GO:0005518)
Dendrite development
(GO:0016358)
Dna damage response
(GO:0006974)
Establishment of cell polarity
(GO:0030010)
Exocytosis
(GO:0006887)
Gamma-tubulin binding
(GO:0043015)
Identical protein binding
(GO:0042802)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Metabolic process
(GO:0008152)
Neuromuscular junction development
(GO:0007528)
Nucleotide binding
(GO:0000166)
Phosphorylation
(GO:0016310)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of fibroblast migration
(GO:0010763)
Positive regulation of intracellular estrogen receptor signaling pathway
(GO:0033148)
Positive regulation of microtubule polymerization
(GO:0031116)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Receptor clustering
(GO:0043113)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of gene expression
(GO:0010468)
Regulation of mapk cascade
(GO:0043408)
Response to hypoxia
(GO:0001666)
Response to organic substance
(GO:0010033)
Small gtpase binding
(GO:0031267)
Transferase activity
(GO:0016740)
Transmission of nerve impulse
(GO:0019226)
Wound healing
(GO:0042060)

Other Information

Proteins

G5E884_MOUSE

Genular Protein ID: 4151560974

Symbol: G5E884_MOUSE

Name: N/A

UniProtKB Accession Codes:

G5E884

Database IDs:

Citations:

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.M400085-MCP200

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 544
Mass: 60608
Checksum: 0CCA15802BEB5E5C
Sequence:

MSNNGVDIQD KPPAPPMRNT STMIGAGSKD TGTLNHGSKP LPPNPEEKKK KDRFYRSILP 
GDKTNKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP EQWARLLQTS NITKSEQKKN 
PQAVLDVLEF YNSKKTSNSQ KYMSFTDKSA EDYNSSNTLN VKTVSETPAV PPVSEDEDDD 
DDATPPPVIA PRPEHTKSVY TRSVIEPLPV TPTRDVATSP ISPTENNTTP PDALTRNTEK 
QKKKPKMSDE EILEKLRSIV SVGDPKKKYT RFEKIGQGAS GTVYTAMDVA TGQEVAIKQM 
NLQQQPKKEL IINEILVMRE NKNPNIVNYL DSYLVGDELW VVMEYLAGGS LTDVVTETCM 
DEGQIAAVCR ECLQALEFLH SNQVIHRDIK SDNILLGMDG SVKLTDFGFC AQITPEQSKR 
STMVGTPYWM APEVVTRKAY GPKVDIWSLG IMAIEMIEGE PPYLNENPLR ALYLIATNGT 
PELQNPEKLS AIFRDFLNRC LEMDVEKRGS AKELLQHQFL KIAKPLSSLT PLIAAAKEAT 
KNNH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.