Details for: AGTR1

Gene ID: 185

Symbol: AGTR1

Ensembl ID: ENSG00000144891

Description: angiotensin II receptor type 1

Associated with

  • Cargo recognition for clathrin-mediated endocytosis
    (R-HSA-8856825)
  • Class a/1 (rhodopsin-like receptors)
    (R-HSA-373076)
  • Clathrin-mediated endocytosis
    (R-HSA-8856828)
  • G alpha (q) signalling events
    (R-HSA-416476)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Gpcr ligand binding
    (R-HSA-500792)
  • Membrane trafficking
    (R-HSA-199991)
  • Peptide ligand-binding receptors
    (R-HSA-375276)
  • Signaling by gpcr
    (R-HSA-372790)
  • Signal transduction
    (R-HSA-162582)
  • Vesicle-mediated transport
    (R-HSA-5653656)
  • Angiotensin-activated signaling pathway
    (GO:0038166)
  • Angiotensin type ii receptor activity
    (GO:0004945)
  • Angiotensin type i receptor activity
    (GO:0001596)
  • Blood vessel diameter maintenance
    (GO:0097746)
  • Bradykinin receptor binding
    (GO:0031711)
  • Calcium-mediated signaling
    (GO:0019722)
  • Cell chemotaxis
    (GO:0060326)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Inflammatory response
    (GO:0006954)
  • Kidney development
    (GO:0001822)
  • Low-density lipoprotein particle remodeling
    (GO:0034374)
  • Maintenance of blood vessel diameter homeostasis by renin-angiotensin
    (GO:0002034)
  • Membrane
    (GO:0016020)
  • Phospholipase c-activating angiotensin-activated signaling pathway
    (GO:0086097)
  • Phospholipase c-activating g protein-coupled receptor signaling pathway
    (GO:0007200)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
    (GO:1903589)
  • Positive regulation of coa-transferase activity
    (GO:1905920)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of macrophage derived foam cell differentiation
    (GO:0010744)
  • Positive regulation of nad(p)h oxidase activity
    (GO:0033864)
  • Positive regulation of phospholipase a2 activity
    (GO:0032430)
  • Positive regulation of protein metabolic process
    (GO:0051247)
  • Positive regulation of reactive oxygen species metabolic process
    (GO:2000379)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Regulation of cell growth
    (GO:0001558)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of inflammatory response
    (GO:0050727)
  • Regulation of renal sodium excretion
    (GO:0035813)
  • Regulation of systemic arterial blood pressure by renin-angiotensin
    (GO:0003081)
  • Regulation of vasoconstriction
    (GO:0019229)
  • Renin-angiotensin regulation of aldosterone production
    (GO:0002018)
  • Rho protein signal transduction
    (GO:0007266)
  • Symbiont entry into host cell
    (GO:0046718)

Other Information

Genular Protein ID: 2236217875

Symbol: AGTR1_HUMAN

Name: AT1BR

UniProtKB Accession Codes:

P30556 Q13725 Q8TBK4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 15 DrugCentral 1 EMBL 10 Ensembl 8 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 6 PIR 2 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1378723

Title: Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor.

PubMed ID: 1378723

DOI: 10.1016/s0006-291x(05)80804-6

PubMed ID: 1543512

Title: Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor.

PubMed ID: 1543512

DOI: 10.1016/0006-291x(92)91600-u

PubMed ID: 1567413

Title: Cloning and characterization of a human angiotensin II type 1 receptor.

PubMed ID: 1567413

DOI: 10.1016/s0006-291x(05)80288-8

PubMed ID: 1550596

Title: Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor.

PubMed ID: 1550596

DOI: 10.1016/0006-291x(92)90570-b

PubMed ID: 1508224

Title: Genetic analysis of the human type-1 angiotensin II receptor.

PubMed ID: 1508224

DOI: 10.1210/mend.6.7.1508224

PubMed ID: 8135787

Title: Novel subtype of human angiotensin II type 1 receptor: cDNA cloning and expression.

PubMed ID: 8135787

DOI: 10.1006/bbrc.1994.1252

PubMed ID: 7792812

Title: Type 1 angiotensin II receptors of adrenal tumors.

PubMed ID: 7792812

DOI: 10.1016/0039-128x(94)00022-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8987975

Title: The active state of the AT1 angiotensin receptor is generated by angiotensin II induction.

PubMed ID: 8987975

DOI: 10.1021/bi961593m

PubMed ID: 15809376

Title: G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor.

PubMed ID: 15809376

DOI: 10.1161/01.cir.0000160867.23556.7d

PubMed ID: 15611106

Title: beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.

PubMed ID: 15611106

DOI: 10.1074/jbc.m412924200

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 26460884

Title: G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation.

PubMed ID: 26460884

DOI: 10.1021/acs.biochem.5b00975

PubMed ID: 33713620

Title: Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.

PubMed ID: 33713620

DOI: 10.1016/j.cell.2021.02.053

PubMed ID: 25913193

Title: Structure of the Angiotensin receptor revealed by serial femtosecond crystallography.

PubMed ID: 25913193

DOI: 10.1016/j.cell.2015.04.011

PubMed ID: 26420482

Title: Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor.

PubMed ID: 26420482

DOI: 10.1074/jbc.m115.689000

PubMed ID: 30639100

Title: Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody.

PubMed ID: 30639100

DOI: 10.1016/j.cell.2018.12.006

PubMed ID: 32079768

Title: Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR.

PubMed ID: 32079768

DOI: 10.1126/science.aay9813

PubMed ID: 16116425

Title: Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.

PubMed ID: 16116425

DOI: 10.1038/ng1623

Sequence Information:

  • Length: 359
  • Mass: 41061
  • Checksum: 35FC856F53E911A6
  • Sequence:
    • MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK 
TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL CKIASASVSF NLYASVFLLT 
CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLLAGLAS LPAIIHRNVF FIENTNITVC 
AFHYESQNST LPIGLGLTKN ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFK 
IIMAIVLFFF FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL 
FYGFLGKKFK RYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK KPAPCFEVE

Genular Protein ID: 3649131496

Symbol: Q6NUP5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NUP5

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 GenomeRNAi 1 IntAct 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 2 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 359
  • Mass: 41089
  • Checksum: 3F13B86F53F62CAE
  • Sequence:
    • MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV IVIYFYMKLK 
TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL CKIASASVSF NLYASVFLLT 
CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI IIWLLAGLAS LPAIIHRNVF FIENTNITVC 
AFHYESQNST LPIGLGLTKN ILGFLFPFLI ILTSYTLIWK ALKRAYEIQK NKPRNDDIFK 
IIMAIVLFFF FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL 
FYGFLGKKFK RYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK KPAPCFEVE

Genular Protein ID: 3929261227

Symbol: D3DNG8_HUMAN

Name: N/A

UniProtKB Accession Codes:

D3DNG8 A0A0A0MSP9

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 RuleBase 2 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 394
  • Mass: 44919
  • Checksum: 9EB6A10F64A09413
  • Sequence:
    • MKKMNHKSTD SPKAPQLRGG VFDIVFATNS TQVIKMILNS STEDGIKRIQ DDCPKAGRHN 
YIFVMIPTLY SIIFVVGIFG NSLVVIVIYF YMKLKTVASV FLLNLALADL CFLLTLPLWA 
VYTAMEYRWP FGNYLCKIAS ASVSFNLYAS VFLLTCLSID RYLAIVHPMK SRLRRTMLVA 
KVTCIIIWLL AGLASLPAII HRNVFFIENT NITVCAFHYE SQNSTLPIGL GLTKNILGFL 
FPFLIILTSY TLIWKALKKA YEIQKNKPRN DDIFKIIMAI VLFFFFSWIP HQIFTFLDVL 
IQLGIIRDCR IADIVDTAMP ITICIAYFNN CLNPLFYGFL GKKFKRYFLQ LLKYIPPKAK 
SHSNLSTKMS TLSYRPSDNV SSSTKKPAPC FEVE

Genular Protein ID: 201944099

Symbol: A0A0A0MSE3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MSE3

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 2 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 388
  • Mass: 44205
  • Checksum: 4521C804B9582A3C
  • Sequence:
    • MLTFTSECGC TTFGVFDIVF ATNSTQVIKM ILNSSTEDGI KRIQDDCPKA GRHNYIFVMI 
PTLYSIIFVV GIFGNSLVVI VIYFYMKLKT VASVFLLNLA LADLCFLLTL PLWAVYTAME 
YRWPFGNYLC KIASASVSFN LYASVFLLTC LSIDRYLAIV HPMKSRLRRT MLVAKVTCII 
IWLLAGLASL PAIIHRNVFF IENTNITVCA FHYESQNSTL PIGLGLTKNI LGFLFPFLII 
LTSYTLIWKA LKKAYEIQKN KPRNDDIFKI IMAIVLFFFF SWIPHQIFTF LDVLIQLGII 
RDCRIADIVD TAMPITICIA YFNNCLNPLF YGFLGKKFKR YFLQLLKYIP PKAKSHSNLS 
TKMSTLSYRP SDNVSSSTKK PAPCFEVE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.