Details for: Pax2

Gene ID: 18504

Symbol: Pax2

Ensembl ID: ENSMUSG00000004231

Description: paired box 2

Associated with

  • Anatomical structure development
    (GO:0048856)
  • Brain morphogenesis
    (GO:0048854)
  • Branching involved in ureteric bud morphogenesis
    (GO:0001658)
  • C2h2 zinc finger domain binding
    (GO:0070742)
  • Camera-type eye development
    (GO:0043010)
  • Cell differentiation
    (GO:0030154)
  • Cell fate determination
    (GO:0001709)
  • Cellular response to glucose stimulus
    (GO:0071333)
  • Cellular response to hydrogen peroxide
    (GO:0070301)
  • Cellular response to mechanical stimulus
    (GO:0071260)
  • Cellular response to retinoic acid
    (GO:0071300)
  • Central nervous system development
    (GO:0007417)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Dopaminergic neuron differentiation
    (GO:0071542)
  • Glial cell differentiation
    (GO:0010001)
  • Inner ear morphogenesis
    (GO:0042472)
  • Kidney development
    (GO:0001822)
  • Mesenchymal to epithelial transition
    (GO:0060231)
  • Mesenchymal to epithelial transition involved in metanephros morphogenesis
    (GO:0003337)
  • Mesodermal cell fate specification
    (GO:0007501)
  • Mesonephric duct development
    (GO:0072177)
  • Mesonephric tubule development
    (GO:0072164)
  • Mesonephric tubule formation
    (GO:0072172)
  • Mesonephros development
    (GO:0001823)
  • Metanephric collecting duct development
    (GO:0072205)
  • Metanephric distal convoluted tubule development
    (GO:0072221)
  • Metanephric epithelium development
    (GO:0072207)
  • Metanephric mesenchymal cell differentiation
    (GO:0072162)
  • Metanephric mesenchyme development
    (GO:0072075)
  • Metanephric nephron tubule formation
    (GO:0072289)
  • Metanephros development
    (GO:0001656)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043154)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
    (GO:0072305)
  • Negative regulation of programmed cell death
    (GO:0043069)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nephric duct formation
    (GO:0072179)
  • Neural tube closure
    (GO:0001843)
  • Optic chiasma development
    (GO:0061360)
  • Optic cup morphogenesis involved in camera-type eye development
    (GO:0002072)
  • Optic nerve development
    (GO:0021554)
  • Optic nerve morphogenesis
    (GO:0021631)
  • Optic nerve structural organization
    (GO:0021633)
  • Pancreas development
    (GO:0031016)
  • Paramesonephric duct development
    (GO:0061205)
  • Phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0043491)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
    (GO:0072108)
  • Positive regulation of metanephric glomerulus development
    (GO:0072300)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Pronephric field specification
    (GO:0039003)
  • Pronephros development
    (GO:0048793)
  • Protein binding
    (GO:0005515)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of metanephros size
    (GO:0035566)
  • Regulation of programmed cell death
    (GO:0043067)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Retinal pigment epithelium development
    (GO:0003406)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Stem cell differentiation
    (GO:0048863)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription factor binding
    (GO:0008134)
  • Ureter development
    (GO:0072189)
  • Ureteric bud development
    (GO:0001657)
  • Ureter maturation
    (GO:0035799)
  • Ureter morphogenesis
    (GO:0072197)
  • Urogenital system development
    (GO:0001655)
  • Vestibulocochlear nerve formation
    (GO:0021650)

Other Information

Genular Protein ID: 1363082471

Symbol: PAX2_MOUSE

Name: Paired box protein Pax-2

UniProtKB Accession Codes:

P32114 A7E2R6

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 3 GO 90 Gene3D 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 UniProtKB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 1977574

Title: Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system.

PubMed ID: 1977574

DOI: 10.1242/dev.109.4.787

PubMed ID: 1516825

Title: Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.

PubMed ID: 1516825

DOI: 10.1101/gad.6.9.1589

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1977575

Title: Spatially and temporally restricted expression of Pax2 during murine neurogenesis.

PubMed ID: 1977575

DOI: 10.1242/dev.109.4.797

PubMed ID: 8943028

Title: The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney.

PubMed ID: 8943028

DOI: 10.1073/pnas.93.24.13870

Sequence Information:

  • Length: 414
  • Mass: 44580
  • Checksum: 7BADF256609F4811
  • Sequence:
    • MDMHCKADPF SAMHRHGGVN QLGGVFVNGR PLPDVVRQRI VELAHQGVRP CDISRQLRVS 
HGCVSKILGR YYETGSIKPG VIGGSKPKVA TPKVVDKIAE YKRQNPTMFA WEIRDRLLAE 
GICDNDTVPS VSSINRIIRT KVQQPFHPTP DGAGTGVTAP GHTIVPSTAS PPVSSASNDP 
VGSYSINGIL GIPRSNGEKR KREEVEVYTD PAHIRGGGGL HLVWTLRDVS EGSVPNGDSQ 
SGVDSLRKHL RADTFTQQQL EALDRVFERP SYPDVFQASE HIKSEQGNEY SLPALTPGLD 
EVKSSLSASA NPELGSNVSG TQTYPVVTGR DMTSTTLPGY PPHVPPTGQG SYPTSTLAGM 
VPGSEFSGNP YSHPQYTAYN EAWRFSNPAL LSSPYYYSAA PRGSAPAAAA YDRH

Genular Protein ID: 3273289473

Symbol: A0A0R4J267_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4J267

Database IDs:

AGR 1 ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 InterPro 6 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 394
  • Mass: 42191
  • Checksum: 5ED4CACF796082AB
  • Sequence:
    • MDMHCKADPF SAMHPGHGGV NQLGGVFVNG RPLPDVVRQR IVELAHQGVR PCDISRQLRV 
SHGCVSKILG RYYETGSIKP GVIGGSKPKV ATPKVVDKIA EYKRQNPTMF AWEIRDRLLA 
EGICDNDTVP SVSSINRIIR TKVQQPFHPT PDGAGTGVTA PGHTIVPSTA SPPVSSASND 
PVGSYSINGI LGIPRSNGEK RKREEDVSEG SVPNGDSQSG VDSLRKHLRA DTFTQQQLEA 
LDRVFERPSY PDVFQASEHI KSEQGNEYSL PALTPGLDEV KSSLSASANP ELGSNVSGTQ 
TYPVVTGRDM TSTTLPGYPP HVPPTGQGSY PTSTLAGMVP GSEFSGNPYS HPQYTAYNEA 
WRFSNPALLS SPYYYSAAPR GSAPAAAAAA YDRH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.