Details for: Pax4

Gene ID: 18506

Symbol: Pax4

Ensembl ID: ENSMUSG00000029706

Description: paired box 4

Associated with

  • Anatomical structure development
    (GO:0048856)
  • Animal organ morphogenesis
    (GO:0009887)
  • Cell differentiation
    (GO:0030154)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Double-stranded dna binding
    (GO:0003690)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of epithelial cell differentiation
    (GO:0030858)
  • Regulation of cell differentiation
    (GO:0045595)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription regulator complex
    (GO:0005667)
  • Type b pancreatic cell differentiation
    (GO:0003309)

Other Information

Genular Protein ID: 3290955892

Symbol: PAX4_MOUSE

Name: Paired box protein Pax-4

UniProtKB Accession Codes:

P32115 B7ZNC7 P97341 Q9QUR1 Q9R091

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 2 CDD 1 CTD 1 DNASU 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 23 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 7 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 4 PRINTS 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 9480859

Title: Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue.

PubMed ID: 9480859

DOI: 10.1006/bbrc.1998.8144

PubMed ID: 9439631

Title: Molecular cloning of mouse paired-box-containing gene (Pax-4) from an islet beta cell line and deduced sequence of human Pax-4.

PubMed ID: 9439631

DOI: 10.1006/bbrc.1997.7935

PubMed ID: 10364449

Title: DNA binding and transactivating properties of the paired and homeobox protein Pax4.

PubMed ID: 10364449

DOI: 10.1006/bbrc.1999.0809

PubMed ID: 10567553

Title: Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a possible role of Pax4 as a transcriptional repressor in the pancreas.

PubMed ID: 10567553

DOI: 10.1128/mcb.19.12.8281

PubMed ID: 10567552

Title: Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development.

PubMed ID: 10567552

DOI: 10.1128/mcb.19.12.8272

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1685142

Title: Pax: a murine multigene family of paired box-containing genes.

PubMed ID: 1685142

DOI: 10.1016/0888-7543(91)90151-4

PubMed ID: 9121556

Title: The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas.

PubMed ID: 9121556

DOI: 10.1038/386399a0

Sequence Information:

  • Length: 349
  • Mass: 38008
  • Checksum: 215E0469F46DF49B
  • Sequence:
    • MQQDGLSSVN QLGGLFVNGR PLPLDTRQQI VQLAIRGMRP CDISRSLKVS NGCVSKILGR 
YYRTGVLEPK CIGGSKPRLA TPAVVARIAQ LKDEYPALFA WEIQHQLCTE GLCTQDKAPS 
VSSINRVLRA LQEDQSLHWT QLRSPAVLAP VLPSPHSNCG APRGPHPGTS HRNRTIFSPG 
QAEALEKEFQ RGQYPDSVAR GKLAAATSLP EDTVRVWFSN RRAKWRRQEK LKWEAQLPGA 
SQDLTVPKNS PGIISAQQSP GSVPSAALPV LEPLSPSFCQ LCCGTAPGRC SSDTSSQAYL 
QPYWDCQSLL PVASSSYVEF AWPCLTTHPV HHLIGGPGQV PSTHCSNWP

Genular Protein ID: 1530155604

Symbol: B7ZNC8_MOUSE

Name: N/A

UniProtKB Accession Codes:

B7ZNC8

Database IDs:

AGR 1 ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 2 GeneTree 1 InterPro 7 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 1 Pfam 2 Proteomes 2 RefSeq 1 RuleBase 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 335
  • Mass: 36585
  • Checksum: F3CB8C64E851AF37
  • Sequence:
    • MQQDGLSSVN QLGGLFVNGR PLPLDTRQQI VQLAIRGMRP CDISRSLKVS NGCVSKILGR 
YYRTGVLEPK CIGGSKPRLA TPAVVARIAQ LKDEYPALFA WEIQHQLCTE GLCTQDKAPS 
VSSINRVLRA LQEDQSLHWT QLRSPAVLAP VLPSPHSNCG APRGPHPGTS HRNRTIFSPG 
QAEALEKEFQ RGQYPDSVAR GKLAAATSLP EDTVRVWFSN RRAKWRRQEK LKWEAQLPGI 
ISAQSPGSVP SAALPVLEPL SPSFCQLCCG TAPGRCSSDT SSQAYLQPYW DCQSLLPVAS 
SSYVEFAWPC LTTHPVHHLI GGPGQVPSTH CSNWP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.