Genular: Defining Cellular Identity and Function

Details for: Pax6

Gene ID: 18508

Symbol: Pax6

Ensembl ID: ENSMUSG00000027168

Description: paired box 6

Associated with

Anterior/posterior pattern specification
(GO:0009952)
Axon guidance
(GO:0007411)
Axonogenesis
(GO:0007409)
Blood vessel development
(GO:0001568)
Brain development
(GO:0007420)
Cell differentiation
(GO:0030154)
Cell fate determination
(GO:0001709)
Cell population proliferation
(GO:0008283)
Cerebral cortex development
(GO:0021987)
Cerebral cortex regionalization
(GO:0021796)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Chromatin remodeling
(GO:0006338)
Co-smad binding
(GO:0070410)
Commitment of neuronal cell to specific neuron type in forebrain
(GO:0021902)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Dna methylation
(GO:0006306)
Dorsal/ventral axis specification
(GO:0009950)
Dorsal/ventral pattern formation
(GO:0009953)
Double-stranded dna binding
(GO:0003690)
Epithelial cell development
(GO:0002064)
Establishment of mitotic spindle orientation
(GO:0000132)
Forebrain-midbrain boundary formation
(GO:0021905)
Forebrain development
(GO:0030900)
Forebrain dorsal/ventral pattern formation
(GO:0021798)
Gene expression
(GO:0010467)
Glandular epithelial cell differentiation
(GO:0002067)
Habenula development
(GO:0021986)
Histone acetyltransferase binding
(GO:0035035)
Hmg box domain binding
(GO:0071837)
Interkinetic nuclear migration
(GO:0022027)
Keratinocyte differentiation
(GO:0030216)
Lens development in camera-type eye
(GO:0002088)
Minor groove of adenine-thymine-rich dna binding
(GO:0003680)
Multicellular organism development
(GO:0007275)
Negative regulation of neuroblast proliferation
(GO:0007406)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Neural crest cell migration
(GO:0001755)
Neuroblast proliferation
(GO:0007405)
Neuron differentiation
(GO:0030182)
Neuron migration
(GO:0001764)
Olfactory bulb development
(GO:0021772)
Oligodendrocyte cell fate specification
(GO:0021778)
Pallium development
(GO:0021543)
Pancreatic a cell development
(GO:0003322)
Pancreatic a cell differentiation
(GO:0003310)
Pituitary gland development
(GO:0021983)
Positive regulation of epithelial cell differentiation
(GO:0030858)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of neuroblast proliferation
(GO:0002052)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
R-smad binding
(GO:0070412)
Regionalization
(GO:0003002)
Regulation of asymmetric cell division
(GO:0009786)
Regulation of cell migration
(GO:0030334)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of neuron projection development
(GO:0010975)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rhombomere morphogenesis
(GO:0021593)
Rna binding
(GO:0003723)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii core promoter sequence-specific dna binding
(GO:0000979)
Salivary gland morphogenesis
(GO:0007435)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Signal transduction involved in regulation of gene expression
(GO:0023019)
Smoothened signaling pathway
(GO:0007224)
Telencephalon regionalization
(GO:0021978)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator binding
(GO:0001221)
Type b pancreatic cell differentiation
(GO:0003309)
Ubiquitin protein ligase binding
(GO:0031625)
Ventral spinal cord development
(GO:0021517)

Other Information

Proteins

Paired box protein Pax-6
Q8VBX9_MOUSE

Genular Protein ID: 834275655

Symbol: PAX6_MOUSE

Name: Paired box protein Pax-6

UniProtKB Accession Codes:

P63015 P32117 P70601 Q3UTV5 Q62222 Q64037 Q8CEI5 Q8VDB5 Q921Q8

Database IDs:

Citations:

PubMed ID: 1687460

Title: Pax-6, a murine paired box gene, is expressed in the developing CNS.

PubMed ID: 1687460

DOI: 10.1242/dev.113.4.1435

PubMed ID: 11779807

Title: Molecular characterization of Pax6(2Neu) through Pax6(10Neu): an extension of the Pax6 allelic series and the identification of two possible hypomorph alleles in the mouse Mus musculus.

PubMed ID: 11779807

DOI: 10.1093/genetics/159.4.1689

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1685142

Title: Pax: a murine multigene family of paired box-containing genes.

PubMed ID: 1685142

DOI: 10.1016/0888-7543(91)90151-4

PubMed ID: 1612585

Title: Small eye (Sey): cloning and characterization of the murine homolog of the human aniridia gene.

PubMed ID: 1612585

DOI: 10.1016/0888-7543(92)90239-o

PubMed ID: 1684639

Title: Mouse small eye results from mutations in a paired-like homeobox-containing gene.

PubMed ID: 1684639

DOI: 10.1038/354522a0

PubMed ID: 9163426

Title: Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas.

PubMed ID: 9163426

DOI: 10.1038/387406a0

PubMed ID: 17901057

Title: Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression.

PubMed ID: 17901057

DOI: 10.1074/jbc.m702795200

PubMed ID: 18628401

Title: Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system.

PubMed ID: 18628401

DOI: 10.1101/gad.471708

PubMed ID: 21084637

Title: Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development.

PubMed ID: 21084637

DOI: 10.1073/pnas.1007866107

PubMed ID: 23990468

Title: The paired-box homeodomain transcription factor Pax6 binds to the upstream region of the TRAP gene promoter and suppresses receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation.

PubMed ID: 23990468

DOI: 10.1074/jbc.m113.461848

Sequence Information:

Length: 422
Mass: 46683
Checksum: C33CDD2C1B13C397
Sequence:

MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQVSN GCVSKILGRY 
YETGSIRPRA IGGSKPRVAT PEVVSKIAQY KRECPSIFAW EIRDRLLSEG VCTNDNIPSV 
SSINRVLRNL ASEKQQMGAD GMYDKLRMLN GQTGSWGTRP GWYPGTSVPG QPTQDGCQQQ 
EGGGENTNSI SSNGEDSDEA QMRLQLKRKL QRNRTSFTQE QIEALEKEFE RTHYPDVFAR 
ERLAAKIDLP EARIQVWFSN RRAKWRREEK LRNQRRQASN TPSHIPISSS FSTSVYQPIP 
QPTTPVSSFT SGSMLGRTDT ALTNTYSALP PMPSFTMANN LPMQPPVPSQ TSSYSCMLPT 
SPSVNGRSYD TYTPPHMQTH MNSQPMGTSG TTSTGLISPG VSVPVQVPGS EPDMSQYWPR 
LQ

Genular Protein ID: 1023318073

Symbol: Q8VBX9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8VBX9

Database IDs:

Citations:

PubMed ID: 12419357

Title: A method for isolating alternatively spliced isoforms: isolation of murine Pax6 isoforms.

PubMed ID: 12419357

DOI: 10.1016/S0003-2697(02)00244-0

PubMed ID: 12388550

Title: PAX6, paired domain influences sequence recognition by the homeodomain.

PubMed ID: 12388550

DOI: 10.1074/jbc.M206478200

Sequence Information:

Length: 221
Mass: 24949
Checksum: 2B5AECC2464BBCE3
Sequence:

MRLQLKRKLQ RNRTSFTQEQ IEALEKEFER THYPDVFARE RLAAKIDLPE ARIQVWFSNR 
RAKWRREEKL RNQRRQASNT PSHIPISSSF STSVYQPIPQ PTTPVSSFTS GSMLGRTDTA 
LTNTYSALPP MPSFTMANNL PMQPPVPSQT SSYSCMLPTS PSVNGRSYDT YTPPHMQTHM 
NSQPMGTSGT TSTGLISPGV SVPVQVPGSE PDMSQYWPRL Q

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pax6

Associated with

Other Information

Pax-6, a murine paired box gene, is expressed in the developing CNS. PubMed ID: 1687460

Molecular characterization of Pax6(2Neu) through Pax6(10Neu): an extension of the Pax6 allelic series and the identification of two possible hypomorph alleles in the mouse Mus musculus. PubMed ID: 11779807

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Pax: a murine multigene family of paired box-containing genes. PubMed ID: 1685142

Small eye (Sey): cloning and characterization of the murine homolog of the human aniridia gene. PubMed ID: 1612585

Mouse small eye results from mutations in a paired-like homeobox-containing gene. PubMed ID: 1684639

Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. PubMed ID: 9163426

Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression. PubMed ID: 17901057

Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system. PubMed ID: 18628401

Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. PubMed ID: 21084637

The paired-box homeodomain transcription factor Pax6 binds to the upstream region of the TRAP gene promoter and suppresses receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation. PubMed ID: 23990468

A method for isolating alternatively spliced isoforms: isolation of murine Pax6 isoforms. PubMed ID: 12419357

PAX6, paired domain influences sequence recognition by the homeodomain. PubMed ID: 12388550