Genular: Defining Cellular Identity and Function

Details for: Kat2b

Gene ID: 18519

Symbol: Kat2b

Ensembl ID: ENSMUSG00000000708

Description: K(lysine) acetyltransferase 2B

Associated with

B-wich complex positively regulates rrna expression
(R-MMU-5250924)
Deubiquitination
(R-MMU-5688426)
Epigenetic regulation of gene expression
(R-MMU-212165)
Esr-mediated signaling
(R-MMU-8939211)
Estrogen-dependent gene expression
(R-MMU-9018519)
Formation of wdr5-containing histone-modifying complexes
(R-MMU-9772755)
Foxo-mediated transcription
(R-MMU-9614085)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Metalloprotease dubs
(R-MMU-5689901)
Notch-hlh transcription pathway
(R-MMU-350054)
Notch1 intracellular domain regulates transcription
(R-MMU-2122947)
Positive epigenetic regulation of rrna expression
(R-MMU-5250913)
Post-translational protein modification
(R-MMU-597592)
Regulation of foxo transcriptional activity by acetylation
(R-MMU-9617629)
Rna polymerase ii transcription
(R-MMU-73857)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-MMU-8936459)
Runx3 regulates notch signaling
(R-MMU-8941856)
Signaling by notch
(R-MMU-157118)
Signaling by notch1
(R-MMU-1980143)
Signaling by nuclear receptors
(R-MMU-9006931)
Signal transduction
(R-MMU-162582)
Transcriptional regulation by runx1
(R-MMU-8878171)
Transcriptional regulation by runx3
(R-MMU-8878159)
Yap1- and wwtr1 (taz)-stimulated gene expression
(R-MMU-2032785)
A band
(GO:0031672)
Acetyltransferase activity
(GO:0016407)
Acyltransferase activity
(GO:0016746)
Acyltransferase activity, transferring groups other than amino-acyl groups
(GO:0016747)
Cell cycle
(GO:0007049)
Cellular response to insulin stimulus
(GO:0032869)
Centrosome
(GO:0005813)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Cyclin-dependent protein serine/threonine kinase inhibitor activity
(GO:0004861)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Diamine n-acetyltransferase activity
(GO:0004145)
Dna-binding transcription factor binding
(GO:0140297)
Gluconeogenesis
(GO:0006094)
Histone acetyltransferase activity
(GO:0004402)
Histone acetyltransferase binding
(GO:0035035)
Histone acetyltransferase complex
(GO:0000123)
Histone deacetylase binding
(GO:0042826)
Histone h3 acetyltransferase activity
(GO:0010484)
Histone h3k9 acetyltransferase activity
(GO:0043992)
Internal peptidyl-lysine acetylation
(GO:0018393)
Kinetochore
(GO:0000776)
Lysine n-acetyltransferase activity, acting on acetyl phosphate as donor
(GO:0004468)
N-terminal peptidyl-lysine acetylation
(GO:0018076)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of centriole replication
(GO:0046600)
Negative regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045736)
Negative regulation of rrna processing
(GO:2000233)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptide-lysine-n-acetyltransferase activity
(GO:0061733)
Peptidyl-lysine acetylation
(GO:0018394)
Positive regulation of attachment of mitotic spindle microtubules to kinetochore
(GO:1902425)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of fatty acid biosynthetic process
(GO:0045723)
Positive regulation of gluconeogenesis
(GO:0045722)
Positive regulation of glycolytic process
(GO:0045821)
Positive regulation of lipid biosynthetic process
(GO:0046889)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription from rna polymerase ii promoter by glucose
(GO:0000432)
Protein acetylation
(GO:0006473)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of dna repair
(GO:0006282)
Regulation of protein adp-ribosylation
(GO:0010835)
Regulation of rna splicing
(GO:0043484)
Rhythmic process
(GO:0048511)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Saga complex
(GO:0000124)
Transcription coactivator activity
(GO:0003713)
Transcription coregulator activity
(GO:0003712)
Transferase activity
(GO:0016740)
Vasodilation
(GO:0042311)

Other Information

Proteins

Histone acetyltransferase KAT2B

Genular Protein ID: 245757363

Symbol: KAT2B_MOUSE

Name: Histone acetyltransferase KAT2B

UniProtKB Accession Codes:

Q9JHD1 Q3U142 Q640M9

Database IDs:

Citations:

PubMed ID: 9742083

Title: Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates.

PubMed ID: 9742083

DOI: 10.1128/mcb.18.10.5659

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11017084

Title: Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development.

PubMed ID: 11017084

DOI: 10.1038/79973

PubMed ID: 12709428

Title: The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine.

PubMed ID: 12709428

DOI: 10.1074/jbc.m300088200

PubMed ID: 17187077

Title: SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells.

PubMed ID: 17187077

DOI: 10.1038/nsmb1185

PubMed ID: 18682553

Title: Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression.

PubMed ID: 18682553

DOI: 10.1073/pnas.0710561105

PubMed ID: 20940255

Title: Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation.

PubMed ID: 20940255

DOI: 10.1242/jcs.068924

Sequence Information:

Length: 813
Mass: 91769
Checksum: 38E52F326794F523
Sequence:

MAEAGGAGSP ALPPAPPHGS PRTLATAAGS SASCGPATAV AAAGTAEGPG GGGSARIAVK 
KAQLRSAPRA KKLEKLGVYS ACKAEESCKC NGWKNPNPSP TPPRGDLQQI IVSLTESCRS 
CSHALAAHVS HLENVSEEEM DRLLGIVLDV EYLFTCVHKE EDADTKQVYF YLFKLLRKSI 
LQRGKPVVEG SLEKKPPFEK PSIEQGVNNF VQYKFSHLPS KERQTTIELA KMFLNRINYW 
HLEAPSQRRL RSPNDDISGY KENYTRWLCY CNVPQFCDSL PRYETTKVFG RTLLRSVFTI 
MRRQLLEQAR QEKDKLPLEK RTLILTHFPK FLSMLEEEVY SQNSPIWDQD FLSASSRTSP 
LGIQTVISPP VTGTALFSSN STSHEQINGG RTSPGCRGSS GLEANPGEKR KMNNSHAPEE 
AKRSRVMGDI PVELINEVMS TITDPAGMLG PETNFLSAHS ARDEAARLEE RRGVIEFHVV 
GNSLNQKPNK KILMWLVGLQ NVFSHQLPRM PKEYITRLVF DPKHKTLALI KDGRVIGGIC 
FRMFPSQGFT EIVFCAVTSN EQVKGYGTHL MNHLKEYHIK HEILNFLTYA DEYAIGYFKK 
QGFSKEIKIP KTKYVGYIKD YEGATLMGCE LNPQIPYTEF SVIIKKQKEI IKKLIERKQA 
QIRKVYPGLS CFKDGVRQIP IESIPGIRET GWKPSGKEKS KEPKDPEQLY STLKNILQQV 
KNHPNAWPFM EPVKRTEAPG YYEVIRFPMD LKTMSERLRN RYYVSKKLFM ADLQRVFTNC 
KEYNPPESEY YKCASILEKF FFSKIKEAGL IDK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Kat2b

Associated with

Other Information

Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. PubMed ID: 9742083

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. PubMed ID: 11017084

The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine. PubMed ID: 12709428

SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells. PubMed ID: 17187077

Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression. PubMed ID: 18682553

Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation. PubMed ID: 20940255