Genular: Defining Cellular Identity and Function

Details for: Pck1

Gene ID: 18534

Symbol: Pck1

Ensembl ID: ENSMUSG00000027513

Description: phosphoenolpyruvate carboxykinase 1, cytosolic

Associated with

Glucose metabolism
(R-MMU-70326)
Metabolism
(R-MMU-1430728)
Metabolism of carbohydrates
(R-MMU-71387)
Carboxy-lyase activity
(GO:0016831)
Carboxylic acid binding
(GO:0031406)
Cellular response to dexamethasone stimulus
(GO:0071549)
Cellular response to glucose stimulus
(GO:0071333)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to potassium ion starvation
(GO:0051365)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Gdp binding
(GO:0019003)
Gluconeogenesis
(GO:0006094)
Glucose homeostasis
(GO:0042593)
Glucose metabolic process
(GO:0006006)
Glyceraldehyde-3-phosphate biosynthetic process
(GO:0046166)
Glycerol biosynthetic process from pyruvate
(GO:0046327)
Gtp binding
(GO:0005525)
Hepatocyte differentiation
(GO:0070365)
Kinase activity
(GO:0016301)
Lipid metabolic process
(GO:0006629)
Lyase activity
(GO:0016829)
Magnesium ion binding
(GO:0000287)
Manganese ion binding
(GO:0030145)
Metal ion binding
(GO:0046872)
Nucleoside diphosphate kinase activity
(GO:0004550)
Nucleotide binding
(GO:0000166)
Oxaloacetate metabolic process
(GO:0006107)
Peptidyl-serine phosphorylation
(GO:0018105)
Phosphoenolpyruvate carboxykinase (gtp) activity
(GO:0004613)
Phosphoenolpyruvate carboxykinase activity
(GO:0004611)
Phosphorylation
(GO:0016310)
Positive regulation of lipid biosynthetic process
(GO:0046889)
Positive regulation of memory t cell differentiation
(GO:0043382)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Propionate catabolic process
(GO:0019543)
Protein serine kinase activity (using gtp as donor)
(GO:0106264)
Purine nucleotide binding
(GO:0017076)
Regulation of lipid biosynthetic process
(GO:0046890)
Response to bacterium
(GO:0009617)
Response to insulin
(GO:0032868)
Response to starvation
(GO:0042594)
Transferase activity
(GO:0016740)
Tricarboxylic acid metabolic process
(GO:0072350)

Other Information

Proteins

PCKGC_MOUSE

Genular Protein ID: 1064627375

Symbol: PCKGC_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9Z2V4 Q3UEH3

Database IDs:

Citations:

PubMed ID: 10221772

Title: Isolation and characterization of the mouse cytosolic phosphoenolpyruvate carboxykinase (GTP) gene: evidence for tissue-specific hypersensitive sites.

PubMed ID: 10221772

DOI: 10.1016/s0303-7207(98)00234-2

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 10938127

Title: Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism.

PubMed ID: 10938127

DOI: 10.1128/mcb.20.17.6508-6517.2000

PubMed ID: 11916968

Title: The roles of ATF3 in liver dysfunction and the regulation of phosphoenolpyruvate carboxykinase gene expression.

PubMed ID: 11916968

DOI: 10.1074/jbc.m200727200

PubMed ID: 11792850

Title: A mutation in the peroxisome proliferator-activated receptor gamma-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice.

PubMed ID: 11792850

DOI: 10.1073/pnas.022616299

PubMed ID: 16100117

Title: Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit.

PubMed ID: 16100117

DOI: 10.1074/jbc.m504119200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 30193097

Title: Dynamic acetylation of phosphoenolpyruvate carboxykinase toggles enzyme activity between gluconeogenic and anaplerotic reactions.

PubMed ID: 30193097

DOI: 10.1016/j.molcel.2018.07.031

PubMed ID: 29230018

Title: A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells.

PubMed ID: 29230018

DOI: 10.1038/s41556-017-0002-2

Sequence Information:

Length: 622
Mass: 69355
Checksum: 9D94738B4A0EE196
Sequence:

MPPQLHNGLD FSAKVIQGSL DSLPQAVRKF VEGNAQLCQP EYIHICDGSE EEYGQLLAHM 
QEEGVIRKLK KYDNCWLALT DPRDVARIES KTVIITQEQR DTVPIPKTGL SQLGRWMSEE 
DFEKAFNARF PGCMKGRTMY VIPFSMGPLG SPLAKIGIEL TDSPYVVASM RIMTRMGISV 
LEALGDGEFI KCLHSVGCPL PLKKPLVNNW ACNPELTLIA HLPDRREIIS FGSGYGGNSL 
LGKKCFALRI ASRLAKEEGW LAEHMLILGI TNPEGKKKYL AAAFPSACGK TNLAMMNPSL 
PGWKVECVGD DIAWMKFDAQ GNLRAINPEN GFFGVAPGTS VKTNPNAIKT IQKNTIFTNV 
AETSDGGVYW EGIDEPLAPG VTITSWKNKE WRPQDAEPCA HPNSRFCTPA SQCPIIDPAW 
ESPEGVPIEG IIFGGRRPEG VPLVYEALSW QHGVFVGAAM RSEATAAAEH KGKIIMHDPF 
AMRPFFGYNF GKYLAHWLSM AHRPAAKLPK IFHVNWFRKD KDGKFLWPGF GENSRVLEWM 
FGRIEGEDSA KLTPIGYIPK ENALNLKGLG GVNVEELFGI SKEFWEKEVE EIDRYLEDQV 
NTDLPYEIER ELRALKQRIS QM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pck1

Associated with

Other Information

Isolation and characterization of the mouse cytosolic phosphoenolpyruvate carboxykinase (GTP) gene: evidence for tissue-specific hypersensitive sites. PubMed ID: 10221772

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. PubMed ID: 10938127

The roles of ATF3 in liver dysfunction and the regulation of phosphoenolpyruvate carboxykinase gene expression. PubMed ID: 11916968

A mutation in the peroxisome proliferator-activated receptor gamma-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice. PubMed ID: 11792850

Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit. PubMed ID: 16100117

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Dynamic acetylation of phosphoenolpyruvate carboxykinase toggles enzyme activity between gluconeogenic and anaplerotic reactions. PubMed ID: 30193097

A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells. PubMed ID: 29230018