Genular: Defining Cellular Identity and Function

Details for: Pcna

Gene ID: 18538

Symbol: Pcna

Ensembl ID: ENSMUSG00000027342

Description: proliferating cell nuclear antigen

Associated with

Base excision repair
(R-MMU-73884)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Chromosome maintenance
(R-MMU-73886)
Dna damage bypass
(R-MMU-73893)
Dna double-strand break repair
(R-MMU-5693532)
Dna strand elongation
(R-MMU-69190)
Dual incision in gg-ner
(R-MMU-5696400)
Dual incision in tc-ner
(R-MMU-6782135)
E3 ubiquitin ligases ubiquitinate target proteins
(R-MMU-8866654)
Extension of telomeres
(R-MMU-180786)
Gap-filling dna repair synthesis and ligation in gg-ner
(R-MMU-5696397)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-MMU-6782210)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Global genome nucleotide excision repair (gg-ner)
(R-MMU-5696399)
Hdr through homologous recombination (hrr)
(R-MMU-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-MMU-5693567)
Homology directed repair
(R-MMU-5693538)
Lagging strand synthesis
(R-MMU-69186)
Leading strand synthesis
(R-MMU-69109)
Metabolism of proteins
(R-MMU-392499)
Mismatch repair (mmr) directed by msh2:msh6 (mutsalpha)
(R-MMU-5358565)
Nucleotide excision repair
(R-MMU-5696398)
Pcna-dependent long patch base excision repair
(R-MMU-5651801)
Polymerase switching
(R-MMU-69091)
Polymerase switching on the c-strand of the telomere
(R-MMU-174411)
Post-translational protein modification
(R-MMU-597592)
Processive synthesis on the c-strand of the telomere
(R-MMU-174414)
Processive synthesis on the lagging strand
(R-MMU-69183)
Protein ubiquitination
(R-MMU-8852135)
Recognition of dna damage by pcna-containing replication complex
(R-MMU-110314)
Removal of the flap intermediate
(R-MMU-69166)
Removal of the flap intermediate from the c-strand
(R-MMU-174437)
Resolution of abasic sites (ap sites)
(R-MMU-73933)
Resolution of ap sites via the multiple-nucleotide patch replacement pathway
(R-MMU-110373)
Rna polymerase ii transcription
(R-MMU-73857)
S phase
(R-MMU-69242)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of dna replication proteins
(R-MMU-4615885)
Synthesis of dna
(R-MMU-69239)
Telomere c-strand (lagging strand) synthesis
(R-MMU-174417)
Telomere maintenance
(R-MMU-157579)
Termination of translesion dna synthesis
(R-MMU-5656169)
Tp53 regulates transcription of cell cycle genes
(R-MMU-6791312)
Tp53 regulates transcription of genes involved in g2 cell cycle arrest
(R-MMU-6804114)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-MMU-6781827)
Transcriptional regulation by tp53
(R-MMU-3700989)
Translesion synthesis by polh
(R-MMU-110320)
Translesion synthesis by poli
(R-MMU-5656121)
Translesion synthesis by polk
(R-MMU-5655862)
Translesion synthesis by rev1
(R-MMU-110312)
Translesion synthesis by y family dna polymerases bypasses lesions on dna template
(R-MMU-110313)
Base-excision repair, gap-filling
(GO:0006287)
Cellular response to uv
(GO:0034644)
Cellular response to xenobiotic stimulus
(GO:0071466)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Damaged dna binding
(GO:0003684)
Dinucleotide insertion or deletion binding
(GO:0032139)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna polymerase binding
(GO:0070182)
Dna polymerase processivity factor activity
(GO:0030337)
Dna repair
(GO:0006281)
Dna replication
(GO:0006260)
Enzyme binding
(GO:0019899)
Histone acetyltransferase binding
(GO:0035035)
Identical protein binding
(GO:0042802)
Intracellular anatomical structure
(GO:0005622)
Leading strand elongation
(GO:0006272)
Male germ cell nucleus
(GO:0001673)
Mismatch repair
(GO:0006298)
Mitotic telomere maintenance via semi-conservative replication
(GO:1902990)
Mutlalpha complex binding
(GO:0032405)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear estrogen receptor binding
(GO:0030331)
Nuclear lamina
(GO:0005652)
Nucleus
(GO:0005634)
Positive regulation of deoxyribonuclease activity
(GO:0032077)
Positive regulation of dna-directed dna polymerase activity
(GO:1900264)
Positive regulation of dna repair
(GO:0045739)
Positive regulation of dna replication
(GO:0045740)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Purine-specific mismatch base pair dna n-glycosylase activity
(GO:0000701)
Receptor tyrosine kinase binding
(GO:0030971)
Regulation of dna replication
(GO:0006275)
Replication fork processing
(GO:0031297)
Response to lipid
(GO:0033993)
Transcription factor binding
(GO:0008134)
Translesion synthesis
(GO:0019985)

Other Information

Proteins

Proliferating cell nuclear antigen

Genular Protein ID: 2331163165

Symbol: PCNA_MOUSE

Name: Proliferating cell nuclear antigen

UniProtKB Accession Codes:

P17918

Database IDs:

Citations:

PubMed ID: 1726365

Title: Nucleotide sequence of murine PCNA: interspecies comparison of the cDNA and the 5' flanking region of the gene.

PubMed ID: 1726365

DOI: 10.3109/10425179109039688

PubMed ID: 1674997

Title: Molecular cloning and structural analysis of mouse gene and pseudogenes for proliferating cell nuclear antigen.

PubMed ID: 1674997

DOI: 10.1093/nar/19.9.2403

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2906640

Title: Cyclin mRNA and protein expression in recombinant interleukin 2-stimulated cloned murine T lymphocytes.

PubMed ID: 2906640

DOI: 10.1002/jcb.240380306

PubMed ID: 9371605

Title: The herpes simplex virus virulence factor ICP34.5 and the cellular protein MyD116 complex with proliferating cell nuclear antigen through the 63-amino-acid domain conserved in ICP34.5, MyD116, and GADD34.

PubMed ID: 9371605

DOI: 10.1128/jvi.71.12.9442-9449.1997

PubMed ID: 12573260

Title: Characterization of the genomic structure and expression of the mouse Apex2 gene.

PubMed ID: 12573260

DOI: 10.1016/s0888-7543(02)00009-5

PubMed ID: 17115032

Title: Tyrosine phosphorylation controls PCNA function through protein stability.

PubMed ID: 17115032

DOI: 10.1038/ncb1501

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24115439

Title: RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication.

PubMed ID: 24115439

DOI: 10.1126/science.1241779

Sequence Information:

Length: 261
Mass: 28785
Checksum: F705CCBDD3205986
Sequence:

MFEARLIQGS ILKKVLEALK DLINEACWDV SSGGVNLQSM DSSHVSLVQL TLRSEGFDTY 
RCDRNLAMGV NLTSMSKILK CAGNEDIITL RAEDNADTLA LVFEAPNQEK VSDYEMKLMD 
LDVEQLGIPE QEYSCVIKMP SGEFARICRD LSHIGDAVVI SCAKNGVKFS ASGELGNGNI 
KLSQTSNVDK EEEAVTIEMN EPVHLTFALR YLNFFTKATP LSPTVTLSMS ADVPLVVEYK 
IADMGHLKYY LAPKIEDEEA S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pcna

Associated with

Other Information

Nucleotide sequence of murine PCNA: interspecies comparison of the cDNA and the 5' flanking region of the gene. PubMed ID: 1726365

Molecular cloning and structural analysis of mouse gene and pseudogenes for proliferating cell nuclear antigen. PubMed ID: 1674997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cyclin mRNA and protein expression in recombinant interleukin 2-stimulated cloned murine T lymphocytes. PubMed ID: 2906640

The herpes simplex virus virulence factor ICP34.5 and the cellular protein MyD116 complex with proliferating cell nuclear antigen through the 63-amino-acid domain conserved in ICP34.5, MyD116, and GADD34. PubMed ID: 9371605

Characterization of the genomic structure and expression of the mouse Apex2 gene. PubMed ID: 12573260

Tyrosine phosphorylation controls PCNA function through protein stability. PubMed ID: 17115032

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. PubMed ID: 24115439