Genular: Defining Cellular Identity and Function

Details for: Furin

Gene ID: 18550

Symbol: Furin

Ensembl ID: ENSMUSG00000030530

Description: furin, paired basic amino acid cleaving enzyme

Associated with

Activation of matrix metalloproteinases
(R-MMU-1592389)
Assembly of active lpl and lipc lipase complexes
(R-MMU-8963889)
Collagen degradation
(R-MMU-1442490)
Degradation of the extracellular matrix
(R-MMU-1474228)
Elastic fibre formation
(R-MMU-1566948)
Expression and processing of neurotrophins
(R-MMU-9036866)
Extracellular matrix organization
(R-MMU-1474244)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
(R-MMU-159854)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(R-MMU-163841)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Ngf processing
(R-MMU-167060)
Plasma lipoprotein assembly, remodeling, and clearance
(R-MMU-174824)
Plasma lipoprotein remodeling
(R-MMU-8963899)
Post-translational protein modification
(R-MMU-597592)
Pre-notch expression and processing
(R-MMU-1912422)
Pre-notch processing in golgi
(R-MMU-1912420)
Removal of aminoterminal propeptides from gamma-carboxylated proteins
(R-MMU-159782)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by notch
(R-MMU-157118)
Signaling by ntrks
(R-MMU-166520)
Signaling by pdgf
(R-MMU-186797)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-MMU-2173796)
Tgf-beta receptor signaling activates smads
(R-MMU-2173789)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-MMU-2173793)
Transport of small molecules
(R-MMU-382551)
Blastocyst formation
(GO:0001825)
Cell surface
(GO:0009986)
Cytokine precursor processing
(GO:0140447)
Dibasic protein processing
(GO:0090472)
Early endosome
(GO:0005769)
Endopeptidase activity
(GO:0004175)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum lumen
(GO:0005788)
Endoplasmic reticulum membrane
(GO:0005789)
Endosome
(GO:0005768)
Extracellular region
(GO:0005576)
Golgi apparatus
(GO:0005794)
Golgi cisterna
(GO:0031985)
Golgi membrane
(GO:0000139)
Heparan sulfate binding
(GO:1904399)
Heparin binding
(GO:0008201)
Hydrolase activity
(GO:0016787)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Metal ion binding
(GO:0046872)
Negative regulation of low-density lipoprotein particle receptor catabolic process
(GO:0032804)
Negative regulation of transforming growth factor beta1 production
(GO:0032911)
Nerve growth factor binding
(GO:0048406)
Nerve growth factor production
(GO:0032902)
Peptidase activity
(GO:0008233)
Peptide binding
(GO:0042277)
Peptide biosynthetic process
(GO:0043043)
Peptide hormone processing
(GO:0016486)
Plasma membrane
(GO:0005886)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of transforming growth factor beta receptor signaling pathway
(GO:0030511)
Positive regulation of viral entry into host cell
(GO:0046598)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Protein maturation
(GO:0051604)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Regulation of cholesterol transport
(GO:0032374)
Regulation of endopeptidase activity
(GO:0052548)
Regulation of protein catabolic process
(GO:0042176)
Regulation of signal transduction
(GO:0009966)
Secretion by cell
(GO:0032940)
Serine-type endopeptidase activity
(GO:0004252)
Serine-type endopeptidase inhibitor activity
(GO:0004867)
Serine-type peptidase activity
(GO:0008236)
Signal peptide processing
(GO:0006465)
Trans-golgi network
(GO:0005802)
Trans-golgi network transport vesicle
(GO:0030140)
Trans-golgi network transport vesicle membrane
(GO:0012510)
Zymogen activation
(GO:0031638)
Zymogen inhibition
(GO:0097341)

Other Information

Proteins

Furin

Genular Protein ID: 213459641

Symbol: FURIN_MOUSE

Name: Furin

UniProtKB Accession Codes:

P23188 Q6GTN6

Database IDs:

Citations:

PubMed ID: 2266110

Title: Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells.

PubMed ID: 2266110

DOI: 10.1016/s0021-9258(18)45669-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9412467

Title: Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway.

PubMed ID: 9412467

DOI: 10.1083/jcb.139.7.1719

PubMed ID: 18713856

Title: Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate.

PubMed ID: 18713856

DOI: 10.1073/pnas.0800340105

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 12794637

Title: The crystal structure of the proprotein processing proteinase furin explains its stringent specificity.

PubMed ID: 12794637

DOI: 10.1038/nsb941

Sequence Information:

Length: 793
Mass: 86772
Checksum: 0F120C2DE2E1A431
Sequence:

MELRSWLLWV VAAAGAVVLL AADAQGQKIF TNTWAVHIPG GPAVADRVAQ KHGFHNLGQI 
FGDYYHFWHR AVTKRSLSPH RPRHSRLQRE PQVKWLEQQV AKRRAKRDVY QEPTDPKFPQ 
QWYLSGVTQR DLNVKEAWAQ GFTGHGIVVS ILDDGIEKNH PDLAGNYDPG ASFDVNDQDP 
DPQPRYTQMN DNRHGTRCAG EVAAVANNGV CGVGVAYNAR IGGVRMLDGE VTDAVEARSL 
GLNPNHIHIY SASWGPEDDG KTVDGPARLA EEAFFRGVSQ GRGGLGSIFV WASGNGGREH 
DSCNCDGYTN SIYTLSISSA TQFGNVPWYS EACSSTLATT YSSGNQNEKQ IVTTDLRQKC 
TESHTGTSAS APLAAGIIAL TLEANKNLTW RDMQHLVVQT SKPAHLNADD WATNGVGRKV 
SHSYGYGLLD AGAMVALAQN WTTVAPQRKC IVEILVEPKD IGKRLEVRKA VTACLGEPNH 
ITRLEHVQAR LTLSYNRRGD LAIHLISPMG TRSTLLAARP HDYSADGFND WAFMTTHSWD 
EDPAGEWVLE IENTSEANNY GTLTKFTLVL YGTAPEGLST PPESSGCKTL TSSQACVVCE 
EGYSLHQKSC VQHCPPGFIP QVLDTHYSTE NDVEIIRASV CTPCHASCAT CQGPAPTDCL 
SCPSHASLDP VEQTCSRQSQ SSRESRPQQQ PPALRPEVEM EPRLQAGLAS HLPEVLAGLS 
CLIIVLIFGI VFLFLHRCSG FSFRGVKVYT MDRGLISYKG LPPEAWQEEC PSDSEEDEGR 
GERTAFIKDQ SAL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Furin

Associated with

Other Information

Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells. PubMed ID: 2266110

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway. PubMed ID: 9412467

Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate. PubMed ID: 18713856

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079