Details for: Pcsk4
Associated with
Other Information
Genular Protein ID: 3148719386
Symbol: PCSK4_MOUSE
Name: Proprotein convertase subtilisin/kexin type 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1372895
Title: Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression.
PubMed ID: 1372895
PubMed ID: 1448111
Title: Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase.
PubMed ID: 1448111
PubMed ID: 8020970
Title: Structure of the gene for the testis-specific proprotein convertase 4 and of its alternate messenger RNA isoforms.
PubMed ID: 8020970
PubMed ID: 9192653
Title: Impaired fertility in mice deficient for the testicular germ-cell protease PC4.
PubMed ID: 9192653
PubMed ID: 11164898
Title: The testicular germ-cell protease PC4 is also expressed in macrophage-like cells of the ovary.
PubMed ID: 11164898
PubMed ID: 16371590
Title: Sperm from mice genetically deficient for the PCSK4 proteinase exhibit accelerated capacitation, precocious acrosome reaction, reduced binding to egg zona pellucida, and impaired fertilizing ability.
PubMed ID: 16371590
PubMed ID: 19342015
Title: PCSK4-null sperm display enhanced protein tyrosine phosphorylation and ADAM2 proteolytic processing during in vitro capacitation.
PubMed ID: 19342015
PubMed ID: 21302280
Title: Enzymatic activity of sperm proprotein convertase is important for mammalian fertilization.
PubMed ID: 21302280
DOI: 10.1002/jcp.22626
PubMed ID: 21080038
Title: The precursor to the germ cell-specific PCSK4 proteinase is inefficiently activated in transfected somatic cells: evidence of interaction with the BiP chaperone.
PubMed ID: 21080038
PubMed ID: 22357636
Title: Alteration in the processing of the ACRBP/sp32 protein and sperm head/acrosome malformations in proprotein convertase 4 (PCSK4) null mice.
PubMed ID: 22357636
Sequence Information:
- Length: 655
- Mass: 73214
- Checksum: 4E4E32CEDECBCB59
- Sequence:
MRPSQTELWL GLTLTLALLA VRWASAQAPI YVSSWAVRVT KGYQEAERLA RKFGFVNLGQ IFPDDQYFHL RHRGVAQQSL TPHWGHRLRL KKDPKVRWFE QQTLRRRVKR SLVVPTDPWF SKQWYMNKEI QQDLNILKAW NQGLTGRGVV ISILDDGIEK DHPDLWANYD PLASYDFNDY DPDPQPRYTP NDENRHGTRC AGEVSATANN GFCGAGVAFN ARIGGVRMLD GAITDIVEAQ SLSLQPQHIH IYSASWGPED DGRTVDGPGL LTQEAFRRGV TKGRQGLGTL FIWASGNGGL HYDNCNCDGY TNSIHTLSVG STTRQGRVPW YSEACASTFT TTFSSGVVTD PQIVTTDLHH QCTDKHTGTS ASAPLAAGMI ALALEANPLL TWRDLQHLVV RASRPAQLQA EDWRINGVGR QVSHHYGYGL LDAGLLVDLA RVWLPTKPQK KCAIRVVHTP TPILPRMLVP KNVTACSDGS RRRLIRSLEH VQVQLSLSYS RRGDLEIFLT SPMGTRSTLV AIRPLDISGQ GYNNWIFMST HYWDEDPQGL WTLGLENKGY YFNTGTLYYY TLLLYGTAED MTARPQAPQV TSRARACVQR DTEGLCQESH SPLSILAGLC LISSQQWWWL YSHPQQPVTE GQASCHPPVT PAAAA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.