Details for: Pdcd1

Gene ID: 18566

Symbol: Pdcd1

Ensembl ID: ENSMUSG00000026285

Description: programmed cell death 1

Associated with

Other Information

Genular Protein ID: 3202564045

Symbol: PDCD1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1396582

Title: Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

PubMed ID: 1396582

DOI: 10.1002/j.1460-2075.1992.tb05481.x

PubMed ID: 9796923

Title: Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses.

PubMed ID: 9796923

DOI: 10.1093/intimm/10.10.1563

PubMed ID: 10485649

Title: Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.

PubMed ID: 10485649

DOI: 10.1016/s1074-7613(00)80089-8

PubMed ID: 11015443

Title: Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation.

PubMed ID: 11015443

DOI: 10.1084/jem.192.7.1027

PubMed ID: 11698646

Title: PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine.

PubMed ID: 11698646

DOI: 10.1073/pnas.231486598

PubMed ID: 11209085

Title: Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice.

PubMed ID: 11209085

DOI: 10.1126/science.291.5502.319

PubMed ID: 11224527

Title: PD-L2 is a second ligand for PD-1 and inhibits T cell activation.

PubMed ID: 11224527

DOI: 10.1038/85330

PubMed ID: 21300912

Title: PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice.

PubMed ID: 21300912

DOI: 10.1084/jem.20100466

PubMed ID: 22641383

Title: Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.

PubMed ID: 22641383

DOI: 10.1084/jem.20112741

PubMed ID: 30487606

Title: FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.

PubMed ID: 30487606

DOI: 10.1038/s41586-018-0756-0

PubMed ID: 15030777

Title: Structural and functional analysis of the costimulatory receptor programmed death-1.

PubMed ID: 15030777

DOI: 10.1016/s1074-7613(04)00051-2

PubMed ID: 18287011

Title: The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors.

PubMed ID: 18287011

DOI: 10.1073/pnas.0712278105

PubMed ID: 18641123

Title: Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2.

PubMed ID: 18641123

DOI: 10.1073/pnas.0804453105

Sequence Information:

  • Length: 288
  • Mass: 31842
  • Checksum: 4AD3C5F0F9D4200A
  • Sequence:
  • MWVRQVPWSF TWAVLQLSWQ SGWLLEVPNG PWRSLTFYPA WLTVSEGANA TFTCSLSNWS 
    EDLMLNWNRL SPSNQTEKQA AFCNGLSQPV QDARFQIIQL PNRHDFHMNI LDTRRNDSGI 
    YLCGAISLHP KAKIEESPGA ELVVTERILE TSTRYPSPSP KPEGRFQGMV IGIMSALVGI 
    PVLLLLAWAL AVFCSTSMSE ARGAGSKDDT LKEEPSAAPV PSVAYEELDF QGREKTPELP 
    TACVHTEYAT IVFTEGLGAS AMGRRGSADG LQGPRPPRHE DGHCSWPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.