Details for: Pdcd4

Gene ID: 18569

Symbol: Pdcd4

Ensembl ID: ENSMUSG00000024975

Description: programmed cell death 4

Associated with

  • Apoptotic process
    (GO:0006915)
  • Bmp signaling pathway
    (GO:0030509)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Epithelial to mesenchymal transition involved in cardiac fibroblast development
    (GO:0060940)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of cytokine production involved in inflammatory response
    (GO:1900016)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of myofibroblast differentiation
    (GO:1904761)
  • Negative regulation of vascular associated smooth muscle cell differentiation
    (GO:1905064)
  • Negative regulation of vascular associated smooth muscle cell proliferation
    (GO:1904706)
  • Nucleus
    (GO:0005634)
  • Positive regulation of endothelial cell apoptotic process
    (GO:2000353)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of non-canonical nf-kappab signal transduction
    (GO:1901224)
  • Positive regulation of smooth muscle cell apoptotic process
    (GO:0034393)
  • Positive regulation of vascular associated smooth muscle cell apoptotic process
    (GO:1905461)
  • Protein binding
    (GO:0005515)
  • Regulation of protein metabolic process
    (GO:0051246)
  • Rna binding
    (GO:0003723)

Other Information

Genular Protein ID: 491922519

Symbol: PDCD4_MOUSE

Name: Programmed cell death protein 4

UniProtKB Accession Codes:

Q61823 P97296 Q3T9A9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 8 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 7 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 8543179

Title: Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death.

PubMed ID: 8543179

DOI: 10.1016/0378-1119(95)00607-9

PubMed ID: 8912629

Title: Molecular cloning of the genes suppressed in RVC lymphoma cells by topoisomerase inhibitors.

PubMed ID: 8912629

DOI: 10.1006/bbrc.1996.1609

PubMed ID: 9714845

Title: Cloning of the TIS gene suppressed by topoisomerase inhibitors.

PubMed ID: 9714845

DOI: 10.1016/s0378-1119(98)00313-8

PubMed ID: 16682971

Title: Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.

PubMed ID: 16682971

DOI: 10.1038/ng1796

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12482958

Title: The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation.

PubMed ID: 12482958

DOI: 10.1128/mcb.23.1.26-37.2003

PubMed ID: 12894233

Title: The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA.

PubMed ID: 12894233

DOI: 10.1038/sj.onc.1206710

PubMed ID: 16024603

Title: Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis.

PubMed ID: 16024603

DOI: 10.1158/0008-5472.can-04-2119

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 17060447

Title: Structural basis for inhibition of translation by the tumor suppressor pdcd4.

PubMed ID: 17060447

DOI: 10.1128/mcb.00867-06

PubMed ID: 17310995

Title: Structure of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4 and characterization of its interaction with eIF4A.

PubMed ID: 17310995

DOI: 10.1038/sj.onc.1210305

PubMed ID: 19153607

Title: Structural basis for translational inhibition by the tumour suppressor Pdcd4.

PubMed ID: 19153607

DOI: 10.1038/emboj.2008.278

Sequence Information:

  • Length: 469
  • Mass: 51702
  • Checksum: 6883BCE5011692F1
  • Sequence:
    • MDIENEQTLN VNPTDPDNLS DSLFSGDEEN AGTEEIKNEI NGNWISASTI NEARINAKAK 
RRLRKNSSRD SGRGDSVSDN GSEAVRSGVA VPTSPKGRLL DRRSRSGKGR GLPKKGGAGG 
KGVWGTPGQV YDVEEVDVKD PNYDDDQENC VYETVVLPLD ETAFEKTLTP IIQEYFEHGD 
TNEVAEMLRD LNLGEMKSGV PVLAVSLALE GKASHREMTS KLLSDLCGTV MSTNDVEKSF 
DKLLKDLPEL ALDTPRAPQL VGQFIARAVG DGILCNTYID SYKGTVDCVQ ARAALDKATV 
LLSMSKGGKR KDSVWGSGGG QQPVNHLVKE IDMLLKEYLL SGDISEAEHC LKELEVPHFH 
HELVYEAIVM VLESTGESAF KMILDLLKSL WKSSTITIDQ MKRGYERIYN EIPDINLDVP 
HSYSVLERFV EECFQAGIIS KQLRDLCPSR GRKRFVSEGD GGRLKPESY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.