Genular: Defining Cellular Identity and Function

Details for: Pdgfa

Gene ID: 18590

Symbol: Pdgfa

Ensembl ID: ENSMUSG00000025856

Description: platelet derived growth factor, alpha

Associated with

Downstream signal transduction
(R-MMU-186763)
Hemostasis
(R-MMU-109582)
Intracellular signaling by second messengers
(R-MMU-9006925)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet degranulation
(R-MMU-114608)
Raf/map kinase cascade
(R-MMU-5673001)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Signaling by pdgf
(R-MMU-186797)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Actin cytoskeleton organization
(GO:0030036)
Angiogenesis
(GO:0001525)
Animal organ morphogenesis
(GO:0009887)
Bone development
(GO:0060348)
Cell population proliferation
(GO:0008283)
Cell projection assembly
(GO:0030031)
Cell surface
(GO:0009986)
Collagen binding
(GO:0005518)
Digestive tract development
(GO:0048565)
Embryonic lung development
(GO:1990401)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Hair follicle development
(GO:0001942)
Identical protein binding
(GO:0042802)
Lung alveolus development
(GO:0048286)
Membrane
(GO:0016020)
Microvillus
(GO:0005902)
Multicellular organism development
(GO:0007275)
Negative chemotaxis
(GO:0050919)
Negative regulation of phosphatidylinositol biosynthetic process
(GO:0010512)
Negative regulation of platelet activation
(GO:0010544)
Platelet-derived growth factor binding
(GO:0048407)
Platelet-derived growth factor complex
(GO:1990265)
Platelet-derived growth factor receptor-alpha signaling pathway
(GO:0035790)
Platelet-derived growth factor receptor binding
(GO:0005161)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of mesenchymal cell proliferation
(GO:0002053)
Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
(GO:0035793)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein autophosphorylation
(GO:0031954)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
(GO:0060683)
Regulation of peptidyl-tyrosine phosphorylation
(GO:0050730)
Regulation of smooth muscle cell migration
(GO:0014910)
Response to wounding
(GO:0009611)
Skin development
(GO:0043588)

Other Information

Proteins

Platelet-derived growth factor subunit A
Q99L56_MOUSE

Genular Protein ID: 1193604522

Symbol: PDGFA_MOUSE

Name: Platelet-derived growth factor subunit A

UniProtKB Accession Codes:

P20033

Database IDs:

Citations:

PubMed ID: 1340209

Title: Characterization of the mouse PDGF A-chain gene. Evolutionary conservation of gene structure, nucleotide sequence and alternative splicing.

PubMed ID: 1340209

DOI: 10.3109/08977199209021542

PubMed ID: 2155144

Title: Selective expression of PDGF A and its receptor during early mouse embryogenesis.

PubMed ID: 2155144

DOI: 10.1016/0012-1606(90)90181-h

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 8681381

Title: PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis.

PubMed ID: 8681381

DOI: 10.1016/s0092-8674(00)81270-2

PubMed ID: 9374392

Title: Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development.

PubMed ID: 9374392

DOI: 10.1242/dev.124.20.3943

PubMed ID: 9876175

Title: Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice.

PubMed ID: 9876175

DOI: 10.1242/dev.126.3.457

PubMed ID: 10903171

Title: Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis.

PubMed ID: 10903171

DOI: 10.1242/dev.127.16.3457

PubMed ID: 10831606

Title: Leydig cell loss and spermatogenic arrest in platelet-derived growth factor (PDGF)-A-deficient mice.

PubMed ID: 10831606

DOI: 10.1083/jcb.149.5.1019

PubMed ID: 11803579

Title: PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis.

PubMed ID: 11803579

DOI: 10.1002/dvdy.1225

PubMed ID: 14514732

Title: Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury.

PubMed ID: 14514732

DOI: 10.1097/01.asn.0000089828.73014.c8

PubMed ID: 15207812

Title: PDGF signaling in cells and mice.

PubMed ID: 15207812

DOI: 10.1016/j.cytogfr.2004.03.003

PubMed ID: 15207813

Title: Insight into the physiological functions of PDGF through genetic studies in mice.

PubMed ID: 15207813

DOI: 10.1016/j.cytogfr.2004.03.005

PubMed ID: 19030102

Title: Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells.

PubMed ID: 19030102

DOI: 10.1371/journal.pone.0003794

Sequence Information:

Length: 211
Mass: 24130
Checksum: BC5814A10ED04B31
Sequence:

MRTWACLLLL GCGYLAHALA EEAEIPRELI ERLARSQIHS IRDLQRLLEI DSVGAEDALE 
TSLRAHGSHA INHVPEKRPV PIRRKRSIEE AIPAVCKTRT VIYEIPRSQV DPTSANFLIW 
PPCVEVKRCT GCCNTSSVKC QPSRVHHRSV KVAKVEYVRK KPKLKEVQVR LEEHLECACA 
TSNLNPDHRE EETGRRRESG KKRKRKRLKP T

Genular Protein ID: 1019214665

Symbol: Q99L56_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q99L56

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 196
Mass: 22281
Checksum: 2610178FACCA3647
Sequence:

MRTWACLLLL GCGYLAHALA EEAEIPRELI ERLARSQIHS IRDLQRLLEI DSVGAEDALE 
TSLRAHGSHA INHVPEKRPV PIRRKRSIEE AIPAVCKTRT VIYEIPRSQV DPTSANFLIW 
PPCVEVKRCT GCCNTSSVKC QPSRVHHRSV KVAKVEYVRK KPKLKEVQVR LEEHLECACA 
TSNLNPDHRE EETDVR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pdgfa

Associated with

Other Information

Characterization of the mouse PDGF A-chain gene. Evolutionary conservation of gene structure, nucleotide sequence and alternative splicing. PubMed ID: 1340209

Selective expression of PDGF A and its receptor during early mouse embryogenesis. PubMed ID: 2155144

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. PubMed ID: 8681381

Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development. PubMed ID: 9374392

Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice. PubMed ID: 9876175

Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. PubMed ID: 10903171

Leydig cell loss and spermatogenic arrest in platelet-derived growth factor (PDGF)-A-deficient mice. PubMed ID: 10831606

PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis. PubMed ID: 11803579

Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury. PubMed ID: 14514732

PDGF signaling in cells and mice. PubMed ID: 15207812

Insight into the physiological functions of PDGF through genetic studies in mice. PubMed ID: 15207813

Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells. PubMed ID: 19030102

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Database document:

PubMed ID: 1340209

PubMed ID: 2155144

PubMed ID: 19468303

PubMed ID: 8681381

PubMed ID: 9374392

PubMed ID: 9876175

PubMed ID: 10903171

PubMed ID: 10831606

PubMed ID: 11803579

PubMed ID: 14514732

PubMed ID: 15207812

PubMed ID: 15207813

PubMed ID: 19030102

PubMed ID: 15489334

PubMed ID: 19468303