Details for: Pdgfb

Gene ID: 18591

Symbol: Pdgfb

Ensembl ID: ENSMUSG00000000489

Description: platelet derived growth factor, B polypeptide

Associated with

  • Downstream signal transduction
    (R-MMU-186763)
  • Hemostasis
    (R-MMU-109582)
  • Intracellular signaling by second messengers
    (R-MMU-9006925)
  • Mapk1/mapk3 signaling
    (R-MMU-5684996)
  • Mapk family signaling cascades
    (R-MMU-5683057)
  • Negative regulation of the pi3k/akt network
    (R-MMU-199418)
  • Pi5p, pp2a and ier3 regulate pi3k/akt signaling
    (R-MMU-6811558)
  • Pip3 activates akt signaling
    (R-MMU-1257604)
  • Platelet activation, signaling and aggregation
    (R-MMU-76002)
  • Platelet degranulation
    (R-MMU-114608)
  • Raf/map kinase cascade
    (R-MMU-5673001)
  • Response to elevated platelet cytosolic ca2+
    (R-MMU-76005)
  • Signaling by pdgf
    (R-MMU-186797)
  • Signaling by receptor tyrosine kinases
    (R-MMU-9006934)
  • Signal transduction
    (R-MMU-162582)
  • Actin cytoskeleton organization
    (GO:0030036)
  • Blood vessel development
    (GO:0001568)
  • Blood vessel morphogenesis
    (GO:0048514)
  • Branching involved in salivary gland morphogenesis
    (GO:0060445)
  • Cardiac vascular smooth muscle cell differentiation
    (GO:0060947)
  • Cell chemotaxis
    (GO:0060326)
  • Cell migration
    (GO:0016477)
  • Cell projection assembly
    (GO:0030031)
  • Cellular response to platelet-derived growth factor stimulus
    (GO:0036120)
  • Chemoattractant activity
    (GO:0042056)
  • Collagen binding
    (GO:0005518)
  • Embryonic placenta development
    (GO:0001892)
  • Endothelial cell proliferation
    (GO:0001935)
  • Epithelial cell proliferation involved in salivary gland morphogenesis
    (GO:0060664)
  • Eye photoreceptor cell development
    (GO:0042462)
  • Fibroblast growth factor receptor signaling pathway
    (GO:0008543)
  • Fibroblast migration
    (GO:0010761)
  • Gene expression
    (GO:0010467)
  • Glial cell development
    (GO:0021782)
  • Growth factor activity
    (GO:0008083)
  • Heart development
    (GO:0007507)
  • Identical protein binding
    (GO:0042802)
  • Interleukin-18-mediated signaling pathway
    (GO:0035655)
  • Monocyte chemotaxis
    (GO:0002548)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of phosphatidylinositol biosynthetic process
    (GO:0010512)
  • Negative regulation of platelet activation
    (GO:0010544)
  • Negative regulation of protein binding
    (GO:0032091)
  • Neuron remodeling
    (GO:0016322)
  • Paracrine signaling
    (GO:0038001)
  • Peptidyl-tyrosine phosphorylation
    (GO:0018108)
  • Phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0043491)
  • Platelet-derived growth factor binding
    (GO:0048407)
  • Platelet-derived growth factor receptor binding
    (GO:0005161)
  • Platelet-derived growth factor receptor signaling pathway
    (GO:0048008)
  • Positive regulation of blood vessel endothelial cell migration
    (GO:0043536)
  • Positive regulation of cell-substrate adhesion
    (GO:0010811)
  • Positive regulation of cell division
    (GO:0051781)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of chemotaxis
    (GO:0050921)
  • Positive regulation of collagen biosynthetic process
    (GO:0032967)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of dna replication
    (GO:0045740)
  • Positive regulation of endothelial cell chemotaxis by vegf-activated vascular endothelial growth factor receptor signaling pathway
    (GO:0038033)
  • Positive regulation of endothelial cell proliferation
    (GO:0001938)
  • Positive regulation of fibroblast growth factor receptor signaling pathway
    (GO:0045743)
  • Positive regulation of fibroblast migration
    (GO:0010763)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glomerular filtration
    (GO:0003104)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of map kinase activity
    (GO:0043406)
  • Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
    (GO:0035793)
  • Positive regulation of mitotic cell cycle, embryonic
    (GO:0045977)
  • Positive regulation of mitotic nuclear division
    (GO:0045840)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein autophosphorylation
    (GO:0031954)
  • Positive regulation of smooth muscle cell migration
    (GO:0014911)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of vasoconstriction
    (GO:0045907)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein homodimerization activity
    (GO:0042803)
  • Protein phosphorylation
    (GO:0006468)
  • Regulation of peptidyl-tyrosine phosphorylation
    (GO:0050730)
  • Response to wounding
    (GO:0009611)
  • Retina development in camera-type eye
    (GO:0060041)
  • Retina vasculature development in camera-type eye
    (GO:0061298)
  • Signaling receptor binding
    (GO:0005102)
  • Substrate-dependent cell migration
    (GO:0006929)
  • Superoxide-generating nadph oxidase activator activity
    (GO:0016176)
  • Synapse assembly
    (GO:0007416)
  • Vasoconstriction
    (GO:0042310)

Other Information

Genular Protein ID: 26655101

Symbol: PDGFB_MOUSE

Name: Platelet-derived growth factor subunit B

UniProtKB Accession Codes:

P31240 Q6P3C4

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 8 DNASU 1 EMBL 14 GO 100 Gene3D 1 GlyCosmos 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2045107

Title: Structure of the murine c-sis proto-oncogene (Sis, PDGFB) encoding the B chain of platelet-derived growth factor.

PubMed ID: 2045107

DOI: 10.1016/0888-7543(91)90515-g

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7958863

Title: Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

PubMed ID: 7958863

DOI: 10.1101/gad.8.16.1875

PubMed ID: 9211853

Title: Pericyte loss and microaneurysm formation in PDGF-B-deficient mice.

PubMed ID: 9211853

DOI: 10.1126/science.277.5323.242

PubMed ID: 10734101

Title: Platelet-derived growth factor receptor beta regulates migration and DNA synthesis in metanephric mesenchymal cells.

PubMed ID: 10734101

DOI: 10.1074/jbc.275.13.9527

PubMed ID: 11264163

Title: Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF beta-receptor null mice.

PubMed ID: 11264163

DOI: 10.1182/blood.v97.7.1990

PubMed ID: 14514732

Title: Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury.

PubMed ID: 14514732

DOI: 10.1097/01.asn.0000089828.73014.c8

PubMed ID: 14561699

Title: Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors.

PubMed ID: 14561699

DOI: 10.1172/jci18549

PubMed ID: 15207812

Title: PDGF signaling in cells and mice.

PubMed ID: 15207812

DOI: 10.1016/j.cytogfr.2004.03.003

PubMed ID: 15207813

Title: Insight into the physiological functions of PDGF through genetic studies in mice.

PubMed ID: 15207813

DOI: 10.1016/j.cytogfr.2004.03.005

PubMed ID: 19030102

Title: Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells.

PubMed ID: 19030102

DOI: 10.1371/journal.pone.0003794

Sequence Information:

  • Length: 241
  • Mass: 27382
  • Checksum: 3C5EB7A2DAD64178
  • Sequence:
    • MNRCWALFLP LCCYLRLVSA EGDPIPEELY EMLSDHSIRS FDDLQRLLHR DSVDEDGAEL 
DLNMTRAHSG VELESSSRGR RSLGSLAAAE PAVIAECKTR TEVFQISRNL IDRTNANFLV 
WPPCVEVQRC SGCCNNRNVQ CRASQVQMRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC 
ETIVTPRPVT RSPGTSREQR AKTPQARVTI RTVRIRRPPK GKHRKFKHTH DKAALKETLG 
A

Genular Protein ID: 452275382

Symbol: A0A0R4IZW4_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4IZW4

Database IDs:

AGR 1 ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 46 Gene3D 1 GeneTree 1 InterPro 4 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 RuleBase 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 241
  • Mass: 27368
  • Checksum: 3C5EA8BDDAC95E78
  • Sequence:
    • MNRCWALFLP LCCYLRLVSA EGDPIPEELY EMLSDHSIRS FDDLQRLLHR DSVDEDGAEL 
DLNMTRAHSG VELESSSRGR RSLGSLAAAE PAVIAECKTR TEVFQISRNL IDRTNANFLV 
WPPCVEVQRC SGCCNNRNVQ CRASQVQMRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC 
ETVVTPRPVT RSPGTSREQR AKTPQARVTI RTVRIRRPPK GKHRKFKHTH DKAALKETLG 
A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.