Genular: Defining Cellular Identity and Function

Details for: Pdgfrb

Gene ID: 18596

Symbol: Pdgfrb

Ensembl ID: ENSMUSG00000024620

Description: platelet derived growth factor receptor, beta polypeptide

Associated with

Downstream signal transduction
(R-MMU-186763)
Intracellular signaling by second messengers
(R-MMU-9006925)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Raf/map kinase cascade
(R-MMU-5673001)
Signaling by pdgf
(R-MMU-186797)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Adrenal gland development
(GO:0030325)
Angiogenesis
(GO:0001525)
Aorta morphogenesis
(GO:0035909)
Atp binding
(GO:0005524)
Blood vessel development
(GO:0001568)
Cardiac myofibril assembly
(GO:0055003)
Cardiac vascular smooth muscle cell differentiation
(GO:0060947)
Cell chemotaxis
(GO:0060326)
Cell migration involved in coronary angiogenesis
(GO:0060981)
Cell migration involved in vasculogenesis
(GO:0035441)
Cellular response to hydrogen peroxide
(GO:0070301)
Chemotaxis
(GO:0006935)
Embryonic organ development
(GO:0048568)
Enzyme binding
(GO:0019899)
Glycosaminoglycan biosynthetic process
(GO:0006024)
Hemopoiesis
(GO:0030097)
Intracellular signal transduction
(GO:0035556)
In utero embryonic development
(GO:0001701)
Kidney development
(GO:0001822)
Kinase activity
(GO:0016301)
Lung growth
(GO:0060437)
Metanephric mesenchymal cell migration
(GO:0035789)
Multicellular organism development
(GO:0007275)
Negative regulation of apoptotic process
(GO:0043066)
Nitrogen compound metabolic process
(GO:0006807)
Nucleotide binding
(GO:0000166)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Phosphatidylinositol 3-kinase binding
(GO:0043548)
Phosphatidylinositol metabolic process
(GO:0046488)
Phosphorylation
(GO:0016310)
Platelet-derived growth factor beta-receptor activity
(GO:0005019)
Platelet-derived growth factor binding
(GO:0048407)
Platelet-derived growth factor receptor-beta signaling pathway
(GO:0035791)
Platelet-derived growth factor receptor activity
(GO:0005017)
Platelet-derived growth factor receptor binding
(GO:0005161)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cell proliferation by vegf-activated platelet derived growth factor receptor signaling pathway
(GO:0038091)
Positive regulation of chemotaxis
(GO:0050921)
Positive regulation of collagen biosynthetic process
(GO:0032967)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
(GO:0035793)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of phospholipase c activity
(GO:0010863)
Positive regulation of phosphoprotein phosphatase activity
(GO:0032516)
Positive regulation of rho protein signal transduction
(GO:0035025)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of peptidyl-tyrosine phosphorylation
(GO:0050730)
Retina vasculature development in camera-type eye
(GO:0061298)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Skeletal system morphogenesis
(GO:0048705)
Smooth muscle cell chemotaxis
(GO:0071670)
Smooth muscle tissue development
(GO:0048745)
Tissue homeostasis
(GO:0001894)
Transferase activity
(GO:0016740)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Vascular endothelial growth factor binding
(GO:0038085)

Other Information

Proteins

Platelet-derived growth factor receptor beta

Genular Protein ID: 366395394

Symbol: PGFRB_MOUSE

Name: Platelet-derived growth factor receptor beta

UniProtKB Accession Codes:

P05622 E9QPE2

Database IDs:

Citations:

PubMed ID: 3020426

Title: Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors.

PubMed ID: 3020426

DOI: 10.1038/323226a0

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 8440729

Title: PDGF-AB requires PDGF receptor alpha-subunits for high-affinity, but not for low-affinity, binding and signal transduction.

PubMed ID: 8440729

DOI: 10.1016/s0021-9258(18)53633-4

PubMed ID: 7958864

Title: Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

PubMed ID: 7958864

DOI: 10.1101/gad.8.16.1888

PubMed ID: 10454568

Title: Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis.

PubMed ID: 10454568

DOI: 10.1128/mcb.19.9.6217

PubMed ID: 14514732

Title: Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury.

PubMed ID: 14514732

DOI: 10.1097/01.asn.0000089828.73014.c8

PubMed ID: 14624252

Title: Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development.

PubMed ID: 14624252

DOI: 10.1371/journal.pbio.0000052

PubMed ID: 15207813

Title: Insight into the physiological functions of PDGF through genetic studies in mice.

PubMed ID: 15207813

DOI: 10.1016/j.cytogfr.2004.03.005

PubMed ID: 15284236

Title: A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity.

PubMed ID: 15284236

DOI: 10.1074/jbc.m406051200

PubMed ID: 14966296

Title: Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.

PubMed ID: 14966296

DOI: 10.1128/mcb.24.5.2190-2201.2004

PubMed ID: 14993293

Title: Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.

PubMed ID: 14993293

DOI: 10.1128/mcb.24.6.2573-2583.2004

PubMed ID: 15753096

Title: Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta).

PubMed ID: 15753096

DOI: 10.1074/jbc.m410265200

PubMed ID: 17620338

Title: Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation.

PubMed ID: 17620338

DOI: 10.1074/jbc.m701797200

PubMed ID: 18948621

Title: Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations.

PubMed ID: 18948621

DOI: 10.1161/circresaha.108.176768

PubMed ID: 18213589

Title: PDGF-B signaling is important for murine cardiac development: its role in developing atrioventricular valves, coronaries, and cardiac innervation.

PubMed ID: 18213589

DOI: 10.1002/dvdy.21436

PubMed ID: 19030102

Title: Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells.

PubMed ID: 19030102

DOI: 10.1371/journal.pone.0003794

PubMed ID: 19656770

Title: The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation.

PubMed ID: 19656770

DOI: 10.1074/mcp.m900195-mcp200

PubMed ID: 19742316

Title: LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation.

PubMed ID: 19742316

DOI: 10.1371/journal.pone.0006922

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21664579

Title: PDGFRbeta signaling regulates mural cell plasticity and inhibits fat development.

PubMed ID: 21664579

DOI: 10.1016/j.devcel.2011.04.019

PubMed ID: 7521735

Title: Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.

PubMed ID: 7521735

DOI: 10.1016/s0969-2126(00)00044-7

Sequence Information:

Length: 1098
Mass: 122790
Checksum: D08FC7C42B77B794
Sequence:

MGLPGVIPAL VLRGQLLLSV LWLLGPQTSR GLVITPPGPE FVLNISSTFV LTCSGSAPVM 
WEQMSQVPWQ EAAMNQDGTF SSVLTLTNVT GGDTGEYFCV YNNSLGPELS ERKRIYIFVP 
DPTMGFLPMD SEDLFIFVTD VTETTIPCRV TDPQLEVTLH EKKVDIPLHV PYDHQRGFTG 
TFEDKTYICK TTIGDREVDS DTYYVYSLQV SSINVSVNAV QTVVRQGESI TIRCIVMGND 
VVNFQWTYPR MKSGRLVEPV TDYLFGVPSR IGSILHIPTA ELSDSGTYTC NVSVSVNDHG 
DEKAINISVI ENGYVRLLET LGDVEIAELH RSRTLRVVFE AYPMPSVLWL KDNRTLGDSG 
AGELVLSTRN MSETRYVSEL ILVRVKVSEA GYYTMRAFHE DDEVQLSFKL QVNVPVRVLE 
LSESHPANGE QTIRCRGRGM PQPNVTWSTC RDLKRCPRKL SPTPLGNSSK EESQLETNVT 
FWEEDQEYEV VSTLRLRHVD QPLSVRCMLQ NSMGGDSQEV TVVPHSLPFK VVVISAILAL 
VVLTVISLII LIMLWQKKPR YEIRWKVIES VSSDGHEYIY VDPVQLPYDS TWELPRDQLV 
LGRTLGSGAF GQVVEATAHG LSHSQATMKV AVKMLKSTAR SSEKQALMSE LKIMSHLGPH 
LNVVNLLGAC TKGGPIYIIT EYCRYGDLVD YLHRNKHTFL QRHSNKHCPP SAELYSNALP 
VGFSLPSHLN LTGESDGGYM DMSKDESIDY VPMLDMKGDI KYADIESPSY MAPYDNYVPS 
APERTYRATL INDSPVLSYT DLVGFSYQVA NGMDFLASKN CVHRDLAARN VLICEGKLVK 
ICDFGLARDI MRDSNYISKG STFLPLKWMA PESIFNSLYT TLSDVWSFGI LLWEIFTLGG 
TPYPELPMND QFYNAIKRGY RMAQPAHASD EIYEIMQKCW EEKFETRPPF SQLVLLLERL 
LGEGYKKKYQ QVDEEFLRSD HPAILRSQAR FPGIHSLRSP LDTSSVLYTA VQPNESDNDY 
IIPLPDPKPD VADEGLPEGS PSLASSTLNE VNTSSTISCD SPLELQEEPQ QAEPEAQLEQ 
PQDSGCPGPL AEAEDSFL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pdgfrb

Associated with

Other Information

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. PubMed ID: 3020426

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

PDGF-AB requires PDGF receptor alpha-subunits for high-affinity, but not for low-affinity, binding and signal transduction. PubMed ID: 8440729

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. PubMed ID: 7958864

Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis. PubMed ID: 10454568

Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury. PubMed ID: 14514732

Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development. PubMed ID: 14624252

Insight into the physiological functions of PDGF through genetic studies in mice. PubMed ID: 15207813

A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity. PubMed ID: 15284236

Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. PubMed ID: 14966296

Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor. PubMed ID: 14993293

Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta). PubMed ID: 15753096

Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation. PubMed ID: 17620338

Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. PubMed ID: 18948621

PDGF-B signaling is important for murine cardiac development: its role in developing atrioventricular valves, coronaries, and cardiac innervation. PubMed ID: 18213589

Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells. PubMed ID: 19030102

The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation. PubMed ID: 19656770

LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PubMed ID: 19742316

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

PDGFRbeta signaling regulates mural cell plasticity and inhibits fat development. PubMed ID: 21664579

Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. PubMed ID: 7521735