Genular: Defining Cellular Identity and Function

Details for: Pdha1

Gene ID: 18597

Symbol: Pdha1

Ensembl ID: ENSMUSG00000031299

Description: pyruvate dehydrogenase E1 alpha 1

Associated with

Glyoxylate metabolism and glycine degradation
(R-MMU-389661)
Metabolism
(R-MMU-1430728)
Metabolism of amino acids and derivatives
(R-MMU-71291)
Metabolism of proteins
(R-MMU-392499)
Mitochondrial protein degradation
(R-MMU-9837999)
Pyruvate metabolism
(R-MMU-70268)
Pyruvate metabolism and citric acid (tca) cycle
(R-MMU-71406)
Regulation of pyruvate dehydrogenase (pdh) complex
(R-MMU-204174)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by retinoic acid
(R-MMU-5362517)
Signal transduction
(R-MMU-162582)
The citric acid (tca) cycle and respiratory electron transport
(R-MMU-1428517)
Acetyl-coa biosynthetic process from pyruvate
(GO:0006086)
Carbohydrate metabolic process
(GO:0005975)
Catalytic complex
(GO:1902494)
Glucose metabolic process
(GO:0006006)
Intracellular membrane-bounded organelle
(GO:0043231)
Mitochondrial pyruvate dehydrogenase complex
(GO:0005967)
Mitochondrion
(GO:0005739)
Myelin sheath
(GO:0043209)
Nucleolus
(GO:0005730)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
(GO:0016624)
Protein binding
(GO:0005515)
Pyruvate dehydrogenase (acetyl-transferring) activity
(GO:0004739)
Pyruvate dehydrogenase (nad+) activity
(GO:0034604)
Pyruvate dehydrogenase activity
(GO:0004738)
Pyruvate dehydrogenase complex
(GO:0045254)
Tricarboxylic acid cycle
(GO:0006099)

Other Information

Proteins

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Genular Protein ID: 2013608809

Symbol: ODPA_MOUSE

Name: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

UniProtKB Accession Codes:

P35486

Database IDs:

Citations:

PubMed ID: 1581363

Title: Isolation and characterisation of the mouse pyruvate dehydrogenase E1 alpha genes.

PubMed ID: 1581363

DOI: 10.1016/0167-4781(92)90102-6

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11708858

Title: Inactivation of the murine pyruvate dehydrogenase (Pdha1) gene and its effect on early embryonic development.

PubMed ID: 11708858

DOI: 10.1006/mgme.2001.3249

PubMed ID: 17314311

Title: Oxidative metabolism of pyruvate is required for meiotic maturation of murine oocytes in vivo.

PubMed ID: 17314311

DOI: 10.1095/biolreprod.106.059899

PubMed ID: 17208939

Title: Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.

PubMed ID: 17208939

DOI: 10.1074/mcp.m600218-mcp200

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18586888

Title: Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male mice.

PubMed ID: 18586888

DOI: 10.1152/ajpheart.00363.2008

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 18630941

Title: Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.

PubMed ID: 18630941

DOI: 10.1021/pr800223m

PubMed ID: 19341700

Title: Monitoring phosphorylation of the pyruvate dehydrogenase complex.

PubMed ID: 19341700

DOI: 10.1016/j.ab.2009.03.040

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 20841503

Title: Beta-cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion.

PubMed ID: 20841503

DOI: 10.1152/ajpendo.00339.2010

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23835326

Title: Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation.

PubMed ID: 23835326

DOI: 10.2337/db12-1650

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

Sequence Information:

Length: 390
Mass: 43232
Checksum: 40898944CE8E0A03
Sequence:

MRKMLAAVSR VLAGSAQKPA SRVLVASRNF ANDATFEIKK CDLHRLEEGP PVTTVLTRED 
GLKYYRMMQT VRRMELKADQ LYKQKIIRGF CHLCDGQEAC CVGLEAGINP TDHLITAYRA 
HGFTFTRGLP VRAILAELTG RRGGCAKGKG GSMHMYAKNF YGGNGIVGAQ VPLGAGIALA 
CKYNGKDEVC LTLYGDGAAN QGQIFEAYNM AALWKLPCIF ICENNRYGMG TSVERAAAST 
DYYKRGDFIP GLRVDGMDIL CVREATKFAA AYCRSGKGPI LMELQTYRYH GHSMSDPGVS 
YRTREEIQEV RSKSDPIMLL KDRMVNSNLA SVEELKEIDV EVRKEIEDAA QFATADPEPP 
LEELGYHIYS SDPPFEVRGA NQWIKFKSVS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pdha1

Associated with

Other Information

Isolation and characterisation of the mouse pyruvate dehydrogenase E1 alpha genes. PubMed ID: 1581363

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Inactivation of the murine pyruvate dehydrogenase (Pdha1) gene and its effect on early embryonic development. PubMed ID: 11708858

Oxidative metabolism of pyruvate is required for meiotic maturation of murine oocytes in vivo. PubMed ID: 17314311

Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS. PubMed ID: 17208939

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male mice. PubMed ID: 18586888

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis. PubMed ID: 18630941

Monitoring phosphorylation of the pyruvate dehydrogenase complex. PubMed ID: 19341700

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Beta-cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion. PubMed ID: 20841503

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. PubMed ID: 23835326

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753