Details for: AGTR2

Gene ID: 186

Symbol: AGTR2

Ensembl ID: ENSG00000180772

Description: angiotensin II receptor type 2

Associated with

  • Class a/1 (rhodopsin-like receptors)
    (R-HSA-373076)
  • G alpha (i) signalling events
    (R-HSA-418594)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Gpcr ligand binding
    (R-HSA-500792)
  • Peptide ligand-binding receptors
    (R-HSA-375276)
  • Signaling by gpcr
    (R-HSA-372790)
  • Signal transduction
    (R-HSA-162582)
  • Angiotensin-activated signaling pathway
    (GO:0038166)
  • Angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure
    (GO:0002033)
  • Angiotensin type ii receptor activity
    (GO:0004945)
  • Blood vessel remodeling
    (GO:0001974)
  • Brain development
    (GO:0007420)
  • Brain renin-angiotensin system
    (GO:0002035)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • Exploration behavior
    (GO:0035640)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • G protein-coupled receptor signaling pathway coupled to cgmp nucleotide second messenger
    (GO:0007199)
  • Inflammatory response
    (GO:0006954)
  • Intracellular signal transduction
    (GO:0035556)
  • Negative regulation of blood vessel endothelial cell migration
    (GO:0043537)
  • Negative regulation of cell growth
    (GO:0030308)
  • Negative regulation of heart rate
    (GO:0010459)
  • Negative regulation of neurotrophin trk receptor signaling pathway
    (GO:0051387)
  • Neuron apoptotic process
    (GO:0051402)
  • Nitric oxide mediated signal transduction
    (GO:0007263)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of branching involved in ureteric bud morphogenesis
    (GO:0090190)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of extrinsic apoptotic signaling pathway
    (GO:2001238)
  • Positive regulation of metanephric glomerulus development
    (GO:0072300)
  • Positive regulation of nitric-oxide synthase activity
    (GO:0051000)
  • Positive regulation of nitric oxide biosynthetic process
    (GO:0045429)
  • Positive regulation of phosphoprotein phosphatase activity
    (GO:0032516)
  • Protein binding
    (GO:0005515)
  • Receptor antagonist activity
    (GO:0048019)
  • Regulation of blood pressure
    (GO:0008217)
  • Regulation of metanephros size
    (GO:0035566)
  • Regulation of systemic arterial blood pressure by circulatory renin-angiotensin
    (GO:0001991)
  • Vasodilation
    (GO:0042311)

Other Information

Genular Protein ID: 2311086221

Symbol: AGTR2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P50052 B2R9V1 Q13016 Q6FGY7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 7 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 15 Ensembl 2 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 7 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7733925

Title: The sequence and genomic organization of the human type 2 angiotensin II receptor.

PubMed ID: 7733925

DOI: 10.1006/bbrc.1995.1537

PubMed ID: 7790004

Title: Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization.

PubMed ID: 7790004

DOI: 10.1016/0888-7543(95)80072-t

PubMed ID: 7945336

Title: Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung.

PubMed ID: 7945336

DOI: 10.1006/bbrc.1994.2402

PubMed ID: 8185599

Title: Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor.

PubMed ID: 8185599

DOI: 10.1006/bbrc.1994.1613

PubMed ID: 7999093

Title: Molecular cloning of the human angiotensin II type 2 receptor cDNA.

PubMed ID: 7999093

DOI: 10.1006/bbrc.1994.2714

PubMed ID: 7719706

Title: Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues.

PubMed ID: 7719706

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12089445

Title: AGTR2 mutations in X-linked mental retardation.

PubMed ID: 12089445

DOI: 10.1126/science.1072191

PubMed ID: 15123706

Title: Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP.

PubMed ID: 15123706

DOI: 10.1074/jbc.m403880200

PubMed ID: 23871722

Title: XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing.

PubMed ID: 23871722

DOI: 10.1016/j.ajhg.2013.06.013

PubMed ID: 28379944

Title: Structural basis for selectivity and diversity in angiotensin II receptors.

PubMed ID: 28379944

DOI: 10.1038/nature22035

PubMed ID: 29967536

Title: Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog.

PubMed ID: 29967536

DOI: 10.1038/s41594-018-0079-8

PubMed ID: 32669569

Title: The discovery of a new antibody for BRIL-fused GPCR structure determination.

PubMed ID: 32669569

DOI: 10.1038/s41598-020-68355-x

PubMed ID: 31899086

Title: The crystal structure of angiotensin II type 2 receptor with endogenous peptide hormone.

PubMed ID: 31899086

DOI: 10.1016/j.str.2019.12.003

Sequence Information:

  • Length: 363
  • Mass: 41184
  • Checksum: FDD7D4E6F9B43E60
  • Sequence:
    • MKGNSTLATT SKNITSGLHF GLVNISGNNE STLNCSQKPS DKHLDAIPIL YYIIFVIGFL 
VNIVVVTLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW ATYYSYRYDW LFGPVMCKVF 
GSFLTLNMFA SIFFITCMSV DRYQSVIYPF LSQRRNPWQA SYIVPLVWCM ACLSSLPTFY 
FRDVRTIEYL GVNACIMAFP PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK 
TNSYGKNRIT RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LAWMGVINSC EVIAVIDLAL 
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRESMSCR KSSSLREMET 
FVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.