Genular: Defining Cellular Identity and Function

Details for: Pdk2

Gene ID: 18604

Symbol: Pdk2

Ensembl ID: ENSMUSG00000038967

Description: pyruvate dehydrogenase kinase, isoenzyme 2

Associated with

Metabolism
(R-MMU-1430728)
Pyruvate metabolism
(R-MMU-70268)
Pyruvate metabolism and citric acid (tca) cycle
(R-MMU-71406)
Regulation of pyruvate dehydrogenase (pdh) complex
(R-MMU-204174)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by retinoic acid
(R-MMU-5362517)
Signal transduction
(R-MMU-162582)
The citric acid (tca) cycle and respiratory electron transport
(R-MMU-1428517)
Atp binding
(GO:0005524)
Carbohydrate metabolic process
(GO:0005975)
Cellular response to nutrient
(GO:0031670)
Cellular response to reactive oxygen species
(GO:0034614)
Cytosol
(GO:0005829)
Glucose homeostasis
(GO:0042593)
Glucose metabolic process
(GO:0006006)
Identical protein binding
(GO:0042802)
Insulin receptor signaling pathway
(GO:0008286)
Intrinsic apoptotic signaling pathway by p53 class mediator
(GO:0072332)
Kinase activity
(GO:0016301)
Mitochondrial pyruvate dehydrogenase complex
(GO:0005967)
Mitochondrion
(GO:0005739)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Phosphorylation
(GO:0016310)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Pyruvate dehydrogenase (acetyl-transferring) kinase activity
(GO:0004740)
Pyruvate dehydrogenase complex
(GO:0045254)
Regulation of acetyl-coa biosynthetic process from pyruvate
(GO:0010510)
Regulation of calcium-mediated signaling
(GO:0050848)
Regulation of cellular ketone metabolic process
(GO:0010565)
Regulation of gluconeogenesis
(GO:0006111)
Regulation of glucose metabolic process
(GO:0010906)
Regulation of ph
(GO:0006885)
Transferase activity
(GO:0016740)

Other Information

Proteins

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

Genular Protein ID: 1251651410

Symbol: PDK2_MOUSE

Name: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial

UniProtKB Accession Codes:

Q9JK42 Q8VC63

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16631612

Title: Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets.

PubMed ID: 16631612

DOI: 10.1016/j.bbrc.2006.03.211

PubMed ID: 17669420

Title: Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.

PubMed ID: 17669420

DOI: 10.1016/j.jmb.2007.06.091

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21411764

Title: PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation.

PubMed ID: 21411764

DOI: 10.1152/ajpregu.00498.2010

PubMed ID: 21190881

Title: Induction of PDK4 in the heart muscle of JVS mice, an animal model of systemic carnitine deficiency, does not appear to reduce glucose utilization by the heart.

PubMed ID: 21190881

DOI: 10.1016/j.ymgme.2010.11.167

PubMed ID: 22360721

Title: Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice.

PubMed ID: 22360721

DOI: 10.1042/bj20112197

Sequence Information:

Length: 407
Mass: 46041
Checksum: DBB9F3F967C6A5B1
Sequence:

MRWVRALLKN ASLAGAPKYI EHFSKFSPSP LSMKQFLDFG SSNACEKTSF TFLRQELPVR 
LANIMKEINL LPDRVLGTPS VQLVQSWYVQ SLLDIMEFLD KDPEDHRTLS QFTDALVTIR 
NRHNDVVPTM AQGVLEYKDT YGDDPVSNQN IQYFLDRFYL SRISIRMLIN QHTLIFDGST 
NPAHPKHIGS IDPNCSVSDV VKDAYDMAKL LCDKYYMASP DLEIQEVNAT NANQPIHMVY 
VPSHLYHMLF ELFKNAMRAT VESHESSLTL PPIKIMVALG EEDLSIKMSD RGGGVPLRKI 
ERLFSYMYST APTPQPGTGG TPLAGFGYGL PISRLYAKYF QGDLQLFSME GFGTDAVIYL 
KALSTDSVER LPVYNKSAWR HYQTIQEAGD WCVPSTEPKN TSTYRVS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pdk2

Associated with

Other Information

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets. PubMed ID: 16631612

Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta. PubMed ID: 17669420

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation. PubMed ID: 21411764

Induction of PDK4 in the heart muscle of JVS mice, an animal model of systemic carnitine deficiency, does not appear to reduce glucose utilization by the heart. PubMed ID: 21190881

Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice. PubMed ID: 22360721