Details for: Enpp2
Associated with
Other Information
Genular Protein ID: 4209655855
Symbol: ENPP2_MOUSE
Name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10702660
Title: Assignment of Pdnp2, the gene encoding phosphodiesterase I/nucleotide pyrophosphatase 2, to mouse chromosome 15D2.
PubMed ID: 10702660
DOI: 10.1159/000015459
PubMed ID: 18175805
Title: Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization.
PubMed ID: 18175805
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15700135
Title: Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression.
PubMed ID: 15700135
PubMed ID: 17208043
Title: Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase.
PubMed ID: 17208043
PubMed ID: 19329427
Title: Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasis-promoting enzyme autotaxin.
PubMed ID: 19329427
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 28414242
Title: Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis.
PubMed ID: 28414242
PubMed ID: 21240269
Title: Crystal structure of autotaxin and insight into GPCR activation by lipid mediators.
PubMed ID: 21240269
DOI: 10.1038/nsmb.1998
PubMed ID: 23027977
Title: Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
PubMed ID: 23027977
PubMed ID: 23688339
Title: Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe.
PubMed ID: 23688339
DOI: 10.1021/cb400150c
PubMed ID: 27780639
Title: Discovery of potent inhibitors of the lysophospholipase autotaxin.
PubMed ID: 27780639
PubMed ID: 29259743
Title: Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo.
PubMed ID: 29259743
Sequence Information:
- Length: 862
- Mass: 98885
- Checksum: 343D44DEAA8FA352
- Sequence:
MARQGCFGSY QVISLFTFAI GVNLCLGFTA SRIKRAEWDE GPPTVLSDSP WTNTSGSCKG RCFELQEVGP PDCRCDNLCK SYSSCCHDFD ELCLKTARGW ECTKDRCGEV RNEENACHCS EDCLSRGDCC TNYQVVCKGE SHWVDDDCEE IRVPECPAGF VRPPLIIFSV DGFRASYMKK GSKVMPNIEK LRSCGTHAPY MRPVYPTKTF PNLYTLATGL YPESHGIVGN SMYDPVFDAT FHLRGREKFN HRWWGGQPLW ITATKQGVRA GTFFWSVSIP HERRILTILQ WLSLPDNERP SVYAFYSEQP DFSGHKYGPF GPEMTNPLRE IDKTVGQLMD GLKQLKLHRC VNVIFVGDHG MEDVTCDRTE FLSNYLTNVD DITLVPGTLG RIRPKIPNNL KYDPKAIIAN LTCKKPDQHF KPYMKQHLPK RLHYANNRRI EDLHLLVERR WHVARKPLDV YKKPSGKCFF QGDHGFDNKV NSMQTVFVGY GPTFKYRTKV PPFENIELYN VMCDLLGLKP APNNGTHGSL NHLLRTNTFR PTLPEEVSRP NYPGIMYLQS DFDLGCTCDD KVEPKNKLEE LNKRLHTKGS TEERHLLYGR PAVLYRTSYD ILYHTDFESG YSEIFLMPLW TSYTISKQAE VSSIPEHLTN CVRPDVRVSP GFSQNCLAYK NDKQMSYGFL FPPYLSSSPE AKYDAFLVTN MVPMYPAFKR VWTYFQRVLV KKYASERNGV NVISGPIFDY NYNGLRDIED EIKQYVEGSS IPVPTHYYSI ITSCLDFTQP ADKCDGPLSV SSFILPHRPD NDESCNSSED ESKWVEELMK MHTARVRDIE HLTGLDFYRK TSRSYSEILT LKTYLHTYES EI
Genular Protein ID: 3150819846
Symbol: G3UXY9_MOUSE
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 19468303
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
PubMed ID: 19468303
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
Sequence Information:
- Length: 910
- Mass: 104635
- Checksum: 7F0252EC6890ED0C
- Sequence:
MARQGCFGSY QVISLFTFAI GVNLCLGFTA SRIKRAEWDE GPPTVLSDSP WTNTSGSCKG RCFELQEVGP PDCRCDNLCK SYSSCCHDFD ELCLKTARGW ECTKDRCGEV RNEENACHCS EDCLSRGDCC TNYQVVCKGE SHWVDDDCEE IRVPECPAGF VRPPLIIFSV DGFRASYMKK GSKVMPNIEK LRSCGTHAPY MRPVYPTKTF PNLYTLATGL YPESHGIVGN SMYDPVFDAT FHLRGREKFN HRWWGGQPLW ITATKQGVRA GTFFWSVSIP HERRILTILQ WLSLPDNERP SVYAFYSEQP DFSGHKYGPF GPEESSYGSP LTPAKRPKRK VAPKRRQERP VAPPKKRRRK LHRMDHYTAE TRQDKMTNPL REIDKTVGQL MDGLKQLKLH RCVNVIFVGD HGMEDVTCDR TEFLSNYLTN VDDITLVPGT LGRIRPKIPN NLKYDPKAII ANLTCKKPDQ HFKPYMKQHL PKRLHYANNR RIEDLHLLVE RRWHVARKPL DVYKKPSGKC FFQGDHGFDN KVNSMQTVFV GYGPTFKYRT KVPPFENIEL YNVMCDLLGL KPAPNNGTHG SLNHLLRTNT FRPTLPEEVS RPNYPGIMYL QSDFDLGCTC DDKNKLEELN KRLHTKGSTE ERHLLYGRPA VLYRTSYDIL YHTDFESGYS EIFLMPLWTS YTISKQAEVS SIPEHLTNCV RPDVRVSPGF SQNCLAYKND KQMSYGFLFP PYLSSSPEAK YDAFLVTNMV PMYPAFKRVW TYFQRVLVKK YASERNGVNV ISGPIFDYNY NGLRDIEDEI KQYVEGSSIP VPTHYYSIIT SCLDFTQPAD KCDGPLSVSS FILPHRPDND ESCNSSEDES KWVEELMKMH TARVRDIEHL TGLDFYRKTS RSYSEILTLK TYLHTYESEI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.