Details for: Pdx1

Gene ID: 18609

Symbol: Pdx1

Ensembl ID: ENSMUSG00000029644

Description: pancreatic and duodenal homeobox 1

Associated with

  • Cell differentiation
    (GO:0030154)
  • Cell population proliferation
    (GO:0008283)
  • Chromatin binding
    (GO:0003682)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Digestive tract development
    (GO:0048565)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-templated transcription
    (GO:0006351)
  • Dna binding
    (GO:0003677)
  • Endocrine pancreas development
    (GO:0031018)
  • Enteroendocrine cell differentiation
    (GO:0035883)
  • Epithelial cell proliferation
    (GO:0050673)
  • Exocrine pancreas development
    (GO:0031017)
  • Glucose homeostasis
    (GO:0042593)
  • Glucose mediated signaling pathway
    (GO:0010255)
  • Glucose metabolic process
    (GO:0006006)
  • Insulin secretion
    (GO:0030073)
  • Intracellular anatomical structure
    (GO:0005622)
  • Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
    (GO:0070059)
  • Liver development
    (GO:0001889)
  • Morphogenesis of embryonic epithelium
    (GO:0016331)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
    (GO:1902236)
  • Negative regulation of epithelial cell proliferation
    (GO:0050680)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of type b pancreatic cell apoptotic process
    (GO:2000675)
  • Nitric oxide mediated signal transduction
    (GO:0007263)
  • Nuclear speck
    (GO:0016607)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Pancreas development
    (GO:0031016)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of insulin secretion
    (GO:0032024)
  • Positive regulation of insulin secretion involved in cellular response to glucose stimulus
    (GO:0035774)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of type b pancreatic cell proliferation
    (GO:1904692)
  • Promoter-specific chromatin binding
    (GO:1990841)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to glucose
    (GO:0009749)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Smoothened signaling pathway
    (GO:0007224)
  • Stem cell differentiation
    (GO:0048863)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Type b pancreatic cell apoptotic process
    (GO:0097050)
  • Type b pancreatic cell differentiation
    (GO:0003309)
  • Type b pancreatic cell proliferation
    (GO:0044342)

Other Information

Genular Protein ID: 2425175426

Symbol: PDX1_MOUSE

Name: Pancreas/duodenum homeobox protein 1

UniProtKB Accession Codes:

P52946 Q3ZB03

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CORUM 1 CTD 1 DNASU 1 EMBL 6 Ensembl 1 GO 64 Gene3D 1 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 7901001

Title: IPF1, a homeodomain-containing transactivator of the insulin gene.

PubMed ID: 7901001

DOI: 10.1002/j.1460-2075.1993.tb06109.x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9710595

Title: An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2).

PubMed ID: 9710595

DOI: 10.1128/mcb.18.9.5109

PubMed ID: 11279116

Title: DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex.

PubMed ID: 11279116

DOI: 10.1074/jbc.m100678200

PubMed ID: 15121856

Title: Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity.

PubMed ID: 15121856

DOI: 10.1128/mcb.24.10.4372-4383.2004

PubMed ID: 12219087

Title: Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

PubMed ID: 12219087

DOI: 10.1038/ng890

PubMed ID: 17052199

Title: Regulation by Per-Arnt-Sim (PAS) kinase of pancreatic duodenal homeobox-1 nuclear import in pancreatic beta-cells.

PubMed ID: 17052199

DOI: 10.1042/bst0340791

PubMed ID: 20637728

Title: Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization.

PubMed ID: 20637728

DOI: 10.1016/j.bbrc.2010.07.035

Sequence Information:

  • Length: 284
  • Mass: 30999
  • Checksum: A57D04569D14E3C4
  • Sequence:
    • MNSEEQYYAA TQLYKDPCAF QRGPVPEFSA NPPACLYMGR QPPPPPPPQF TSSLGSLEQG 
SPPDISPYEV PPLASDDPAG AHLHHHLPAQ LGLAHPPPGP FPNGTEPGGL EEPNRVQLPF 
PWMKSTKAHA WKGQWAGGAY TAEPEENKRT RTAYTRAQLL ELEKEFLFNK YISRPRRVEL 
AVMLNLTERH IKIWFQNRRM KWKKEEDKKR SSGTPSGGGG GEEPEQDCAV TSGEELLAVP 
PLPPPGGAVP PGVPAAVREG LLPSGLSVSP QPSSIAPLRP QEPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.