Details for: Prf1
Associated with
Other Information
Genular Protein ID: 2964536793
Symbol: PERF_MOUSE
Name: Cytolysin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2783549
Title: The structure of the mouse lymphocyte pore-forming protein perforin.
PubMed ID: 2783549
PubMed ID: 2303785
Title: Genomic organization of the mouse pore-forming protein (perforin) gene and localization to chromosome 10. Similarities to and differences from C9.
PubMed ID: 2303785
PubMed ID: 3261391
Title: Homology of perforin to the ninth component of complement (C9).
PubMed ID: 3261391
DOI: 10.1038/334525a0
PubMed ID: 2783486
Title: Cloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic T-cell granules with homology to complement component C9.
PubMed ID: 2783486
PubMed ID: 1401900
Title: Structure and function of the murine perforin promoter and upstream region. Reciprocal gene activation or silencing in perforin positive and negative cells.
PubMed ID: 1401900
PubMed ID: 3190678
Title: The primary structure of the lymphocyte pore-forming protein perforin: partial amino acid sequencing and determination of isoelectric point.
PubMed ID: 3190678
PubMed ID: 2783478
Title: Phosphorylcholine acts as a Ca2+-dependent receptor molecule for lymphocyte perforin.
PubMed ID: 2783478
DOI: 10.1038/337272a0
PubMed ID: 2040805
Title: Subcellular localization of perforin and serine esterase in lymphokine-activated killer cells and cytotoxic T cells by immunogold labeling.
PubMed ID: 2040805
PubMed ID: 8164737
Title: Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice.
PubMed ID: 8164737
DOI: 10.1038/369031a0
PubMed ID: 7520535
Title: Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways.
PubMed ID: 7520535
DOI: 10.1038/370650a0
PubMed ID: 7972104
Title: A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.
PubMed ID: 7972104
PubMed ID: 7526382
Title: Immune function in mice lacking the perforin gene.
PubMed ID: 7526382
PubMed ID: 19446473
Title: The molecular basis for perforin oligomerization and transmembrane pore assembly.
PubMed ID: 19446473
PubMed ID: 35705808
Title: Caspase-7 activates ASM to repair gasdermin and perforin pores.
PubMed ID: 35705808
PubMed ID: 21037563
Title: The structural basis for membrane binding and pore formation by lymphocyte perforin.
PubMed ID: 21037563
DOI: 10.1038/nature09518
PubMed ID: 26306037
Title: Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.
PubMed ID: 26306037
PubMed ID: 35148176
Title: The pore conformation of lymphocyte perforin.
PubMed ID: 35148176
Sequence Information:
- Length: 554
- Mass: 62081
- Checksum: 9E5964CE9FE8A0D8
- Sequence:
MATCLFLLGL FLLLPRPVPA PCYTATRSEC KQKHKFVPGV WMAGEGMDVT TLRRSGSFPV NTQRFLRPDR TCTLCKNSLM RDATQRLPVA ITHWRPHSSH CQRNVAAAKV HSTEGVAREA AANINNDWRV GLDVNPRPEA NMRASVAGSH SKVANFAAEK TYQDQYNFNS DTVECRMYSF RLVQKPPLHL DFKKALRALP RNFNSSTEHA YHRLISSYGT HFITAVDLGG RISVLTALRT CQLTLNGLTA DEVGDCLNVE AQVSIGAQAS VSSEYKACEE KKKQHKMATS FHQTYRERHV EVLGGPLDST HDLLFGNQAT PEQFSTWTAS LPSNPGLVDY SLEPLHTLLE EQNPKREALR QAISHYIMSR ARWQNCSRPC RSGQHKSSHD SCQCECQDSK VTNQDCCPRQ RGLAHLVVSN FRAEHLWGDY TTATDAYLKV FFGGQEFRTG VVWNNNNPRW TDKMDFENVL LSTGGPLRVQ VWDADYGWDD DLLGSCDRSP HSGFHEVTCE LNHGRVKFSY HAKCLPHLTG GTCLEYAPQG LLGDPPGNRS GAVW
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.