Genular: Defining Cellular Identity and Function

Details for: Abcb1a

Gene ID: 18671

Symbol: Abcb1a

Ensembl ID: ENSMUSG00000040584

Description: ATP-binding cassette, sub-family B member 1A

Associated with

Abc-family proteins mediated transport
(R-MMU-382556)
Atorvastatin adme
(R-MMU-9754706)
Drug adme
(R-MMU-9748784)
Prednisone adme
(R-MMU-9757110)
Transport of small molecules
(R-MMU-382551)
Abc-type transporter activity
(GO:0140359)
Abc-type xenobiotic transporter activity
(GO:0008559)
Apical plasma membrane
(GO:0016324)
Atpase-coupled intramembrane lipid transporter activity
(GO:0140326)
Atpase-coupled transmembrane transporter activity
(GO:0042626)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Carboxylic acid transmembrane transport
(GO:1905039)
Carboxylic acid transmembrane transporter activity
(GO:0046943)
Cell surface
(GO:0009986)
Ceramide floppase activity
(GO:0099038)
Ceramide translocation
(GO:0099040)
Cytoplasm
(GO:0005737)
Efflux transmembrane transporter activity
(GO:0015562)
Export across plasma membrane
(GO:0140115)
Floppase activity
(GO:0140328)
G2/m transition of mitotic cell cycle
(GO:0000086)
Intercellular canaliculus
(GO:0046581)
Membrane
(GO:0016020)
Nucleotide binding
(GO:0000166)
Phosphatidylcholine floppase activity
(GO:0090554)
Phosphatidylethanolamine flippase activity
(GO:0090555)
Phospholipid translocation
(GO:0045332)
Plasma membrane
(GO:0005886)
Positive regulation of anion channel activity
(GO:1901529)
Regulation of chloride transport
(GO:2001225)
Regulation of response to osmotic stress
(GO:0047484)
Stem cell proliferation
(GO:0072089)
Terpenoid transport
(GO:0046865)
Transepithelial transport
(GO:0070633)
Transmembrane transport
(GO:0055085)
Transmembrane transporter activity
(GO:0022857)
Ubiquitin protein ligase binding
(GO:0031625)
Xenobiotic detoxification by transmembrane export across the plasma membrane
(GO:1990961)
Xenobiotic transmembrane transporter activity
(GO:0042910)
Xenobiotic transport across blood-brain barrier
(GO:1990962)

Other Information

Proteins

MDR1A

Genular Protein ID: 617914411

Symbol: MDR1A_MOUSE

Name: MDR1A

UniProtKB Accession Codes:

P21447 Q5I1Y5

Database IDs:

Citations:

PubMed ID: 1969610

Title: Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.

PubMed ID: 1969610

DOI: 10.1128/mcb.10.4.1652-1663.1990

PubMed ID: 1972547

Title: Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells.

PubMed ID: 1972547

DOI: 10.1128/mcb.10.7.3596-3606.1990

PubMed ID: 2473069

Title: Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. Evidence that distinct P-glycoprotein precursors are encoded by unique mdr genes.

PubMed ID: 2473069

DOI: 10.1016/s0021-9258(18)80173-9

PubMed ID: 8898203

Title: MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine.

PubMed ID: 8898203

DOI: 10.1016/s0092-8674(00)81370-7

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19325113

Title: Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding.

PubMed ID: 19325113

DOI: 10.1126/science.1168750

Sequence Information:

Length: 1276
Mass: 140647
Checksum: 542E101DF18DDC52
Sequence:

MELEEDLKGR ADKNFSKMGK KSKKEKKEKK PAVSVLTMFR YAGWLDRLYM LVGTLAAIIH 
GVALPLMMLI FGDMTDSFAS VGNVSKNSTN MSEADKRAMF AKLEEEMTTY AYYYTGIGAG 
VLIVAYIQVS FWCLAAGRQI HKIRQKFFHA IMNQEIGWFD VHDVGELNTR LTDDVSKINE 
GIGDKIGMFF QAMATFFGGF IIGFTRGWKL TLVILAISPV LGLSAGIWAK ILSSFTDKEL 
HAYAKAGAVA EEVLAAIRTV IAFGGQKKEL ERYNNNLEEA KRLGIKKAIT ANISMGAAFL 
LIYASYALAF WYGTSLVISK EYSIGQVLTV FFSVLIGAFS VGQASPNIEA FANARGAAYE 
VFKIIDNKPS IDSFSKSGHK PDNIQGNLEF KNIHFSYPSR KEVQILKGLN LKVKSGQTVA 
LVGNSGCGKS TTVQLMQRLY DPLDGMVSID GQDIRTINVR YLREIIGVVS QEPVLFATTI 
AENIRYGRED VTMDEIEKAV KEANAYDFIM KLPHQFDTLV GERGAQLSGG QKQRIAIARA 
LVRNPKILLL DEATSALDTE SEAVVQAALD KAREGRTTIV IAHRLSTVRN ADVIAGFDGG 
VIVEQGNHDE LMREKGIYFK LVMTQTAGNE IELGNEACKS KDEIDNLDMS SKDSGSSLIR 
RRSTRKSICG PHDQDRKLST KEALDEDVPP ASFWRILKLN STEWPYFVVG IFCAIINGGL 
QPAFSVIFSK VVGVFTNGGP PETQRQNSNL FSLLFLILGI ISFITFFLQG FTFGKAGEIL 
TKRLRYMVFK SMLRQDVSWF DDPKNTTGAL TTRLANDAAQ VKGATGSRLA VIFQNIANLG 
TGIIISLIYG WQLTLLLLAI VPIIAIAGVV EMKMLSGQAL KDKKELEGSG KIATEAIENF 
RTVVSLTREQ KFETMYAQSL QIPYRNAMKK AHVFGITFSF TQAMMYFSYA ACFRFGAYLV 
TQQLMTFENV LLVFSAIVFG AMAVGQVSSF APDYAKATVS ASHIIRIIEK TPEIDSYSTQ 
GLKPNMLEGN VQFSGVVFNY PTRPSIPVLQ GLSLEVKKGQ TLALVGSSGC GKSTVVQLLE 
RFYDPMAGSV FLDGKEIKQL NVQWLRAQLG IVSQEPILFD CSIAENIAYG DNSRVVSYEE 
IVRAAKEANI HQFIDSLPDK YNTRVGDKGT QLSGGQKQRI AIARALVRQP HILLLDEATS 
ALDTESEKVV QEALDKAREG RTCIVIAHRL STIQNADLIV VIQNGKVKEH GTHQQLLAQK 
GIYFSMVSVQ AGAKRS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Abcb1a

Associated with

Other Information

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities. PubMed ID: 1969610

Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells. PubMed ID: 1972547

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. Evidence that distinct P-glycoprotein precursors are encoded by unique mdr genes. PubMed ID: 2473069

MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. PubMed ID: 8898203

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079